※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-BRR-01409	Bra027269	Bra027269
2		EKS-BRR-01414	Bra016220	Bra016220
3		EKS-BRR-01420	Bra039858	Bra039858
4		EKS-BRR-01412	Bra023483	Bra023483
5		EKS-BRR-01421	Bra003600	Bra003600
6		EKS-BRR-01410	Bra004366	Bra004366
7		EKS-BRR-01413	Bra008742	Bra008742
8		EKS-BRR-01418	Bra035132	Bra035132
9		EKS-BRR-01416	Bra035282	Bra035282
10		EKS-BRR-01419	Bra013762	Bra013762
11		EKS-BRR-01422	Bra006265	Bra006265
12		EKS-BRR-01411	Bra038106	Bra038106
13		EKS-BRR-01417	Bra033169	Bra033169
14		EKS-BRR-01415	Bra007914	Bra007914