※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GLM-00207	GLYMA01G07641
2		EKS-GLM-00205	GLYMA02G13220
3		EKS-GLM-00215	GLYMA20G35970
4		EKS-GLM-00218	GLYMA12G15890
5		EKS-GLM-00216	GLYMA13G10450
6		EKS-GLM-00203	GLYMA12G27300
7		EKS-GLM-00217	GLYMA13G42580
8		EKS-GLM-00209	GLYMA19G01000
9		EKS-GLM-00204	GLYMA06G36130
10		EKS-GLM-00208	GLYMA12G35510
11		EKS-GLM-00211	GLYMA20G16510
12		EKS-GLM-00212	GLYMA08G23921
13		EKS-GLM-00206	GLYMA13G34970
14		EKS-GLM-00214	GLYMA07G00500
15		EKS-GLM-00213	GLYMA10G31630
16		EKS-GLM-00210	GLYMA05G08640