※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

  Reviewed (0)  or Unreviewed (10) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-OCP-00054	ENSOPRG00000011133	PAK2
2		EKS-OCP-00060	ENSOPRG00000015422	STRADB
3		EKS-OCP-00053	ENSOPRG00000004353	PAK1
4		EKS-OCP-00052	ENSOPRG00000004095	STK25
5		EKS-OCP-00056	ENSOPRG00000009971	MAP4K4
6		EKS-OCP-00057	ENSOPRG00000009634	TAOK2
7		EKS-OCP-00059	ENSOPRG00000006899	PAK6
8		EKS-OCP-00055	ENSOPRG00000006683	PAK4
9		EKS-OCP-00058	ENSOPRG00000002464	OXSR1
10		EKS-OCP-00061	ENSOPRG00000014917	STRADA