※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

  Reviewed (0)  or Unreviewed (11) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PEM-00173	ENSPMAG00000002691	TAOK2
2		EKS-PEM-00176	ENSPMAG00000007154	STK39
3		EKS-PEM-00178	ENSPMAG00000007328	PAK4
4		EKS-PEM-00175	ENSPMAG00000001872	MYO3B
5		EKS-PEM-00177	ENSPMAG00000002170	PAK7 (2 of 2)
6		EKS-PEM-00170	ENSPMAG00000000147	MAP4K4
7		EKS-PEM-00174	ENSPMAG00000009510	MAP4K5
8		EKS-PEM-00171	ENSPMAG00000009522	SLK
9		EKS-PEM-00168	ENSPMAG00000009054	MAP4K2
10		EKS-PEM-00172	ENSPMAG00000008567	PAK7 (1 of 2)
11		EKS-PEM-00169	ENSPMAG00000008275	STK24