※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PHP-00668	PP1S68_168V6
2		EKS-PHP-00662	PP1S27_49V6	A9RT39_PHYPA; PHYPADRAFT_119152
3		EKS-PHP-00667	PP1S56_2V6
4		EKS-PHP-00660	PP1S31_249V6	A9RVK0_PHYPA; PHYPADRAFT_119967
5		EKS-PHP-00664	PP1S39_232V6	A9S0F3_PHYPA; PHYPADRAFT_122214
6		EKS-PHP-00665	PP1S227_24V6	A9TGS0_PHYPA; PHYPADRAFT_145446
7		EKS-PHP-00661	PP1S13_360V6
8		EKS-PHP-00659	PP1S98_82V6
9		EKS-PHP-00666	PP1S59_173V6
10		EKS-PHP-00663	PP1S407_24V6