※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-POT-01652	POPTR_0010s16490	POPTRDRAFT_226120
2		EKS-POT-01662	POPTR_0004s20580	POPTRDRAFT_921294
3		EKS-POT-01656	POPTR_0003s18550	POPTRDRAFT_647398
4		EKS-POT-01657	POPTR_0001s11280
5		EKS-POT-01660	POPTR_0008s16380	POPTRDRAFT_873765
6		EKS-POT-01653	POPTR_0011s11710
7		EKS-POT-01654	POPTR_0001s40810
8		EKS-POT-01663	POPTR_0753s00210
9		EKS-POT-01658	POPTR_0003s14600	POPTRDRAFT_413197
10		EKS-POT-01661	POPTR_0016s05000
11		EKS-POT-01655	POPTR_0001s34910	POPTRDRAFT_1068795
12		EKS-POT-01659	POPTR_0001s07500	POPTRDRAFT_708402