Procavia capensis      STE      STE20

※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusEKPD IDGene IDGene Name
1
EKS-PRC-00048
ENSPCAG00000015097
STK25
2
EKS-PRC-00051
ENSPCAG00000000463
PAK6
3
EKS-PRC-00046
ENSPCAG00000000324
PAK2
4
EKS-PRC-00052
ENSPCAG00000000565
PAK7
5
EKS-PRC-00047
ENSPCAG00000009832
STK3
6
EKS-PRC-00049
ENSPCAG00000010973
PAK4
7
EKS-PRC-00050
ENSPCAG00000013718
STK39