※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SEM-00924	SELMODRAFT_136846	SELMODRAFT_136846
2		EKS-SEM-00926	SELMODRAFT_449475	MAP4K4; SELMODRAFT_449475
3		EKS-SEM-00925	SELMODRAFT_43202	SELMODRAFT_43202
4		EKS-SEM-00918	SELMODRAFT_117572	SELMODRAFT_117572
5		EKS-SEM-00919	SELMODRAFT_406890	SELMODRAFT_406890
6		EKS-SEM-00921	SELMODRAFT_119926	SELMODRAFT_119926
7		EKS-SEM-00923	SELMODRAFT_92988	SELMODRAFT_92988
8		EKS-SEM-00920	SELMODRAFT_30736	SELMODRAFT_30736
9		EKS-SEM-00922	SELMODRAFT_62369	SELMODRAFT_42395, SELMODRAFT_62369; SELMODRAFT_62369