※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SOT-01019	PGSC0003DMG400010274	PGSC0003DMG400010274
2		EKS-SOT-01018	PGSC0003DMG400010262	PGSC0003DMG400010262
3		EKS-SOT-01016	PGSC0003DMG400010261	PGSC0003DMG400010261
4		EKS-SOT-01015	PGSC0003DMG400045985	PGSC0003DMG400045985
5		EKS-SOT-01012	PGSC0003DMG402014218	PGSC0003DMG402014218
6		EKS-SOT-01014	PGSC0003DMG400016323	PGSC0003DMG400016323
7		EKS-SOT-01013	PGSC0003DMG400028914	PGSC0003DMG400028914
8		EKS-SOT-01020	PGSC0003DMG400035338	PGSC0003DMG400035338
9		EKS-SOT-01017	PGSC0003DMG400035685	PGSC0003DMG400035685