※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SOB-01087	Sb01g007720	Sb01g007720; 170F8.3; SORBIDRAFT_01g007720
2		EKS-SOB-01086	Sb02g034260	SORBIDRAFT_02g034260; SB02G034260; Sb02g034260
3		EKS-SOB-01090	Sb01g049690
4		EKS-SOB-01091	Sb01g016990	SB01G016990; SORBIDRAFT_01g016990; Sb01g016990
5		EKS-SOB-01093	Sb08g001050	SB08G001050; Sb08g001050; SORBIDRAFT_08g001050
6		EKS-SOB-01088	Sb10g014850	Sb10g014850; SORBIDRAFT_10g014850; SB10G014850
7		EKS-SOB-01089	Sb04g035640	Sb04g035640; SB04G035640; SORBIDRAFT_04g035640
8		EKS-SOB-01092	Sb04g005337	SB04G005337; Sb04g005337; SORBIDRAFT_04g005337