※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TUT-00075	ENSTTRG00000015254	STK25
2		EKS-TUT-00080	ENSTTRG00000008763	PAK1
3		EKS-TUT-00072	ENSTTRG00000007620	STK4
4		EKS-TUT-00077	ENSTTRG00000007474	SLK
5		EKS-TUT-00081	ENSTTRG00000013179	TAOK3
6		EKS-TUT-00076	ENSTTRG00000006440
7		EKS-TUT-00079	ENSTTRG00000013965	PAK7
8		EKS-TUT-00073	ENSTTRG00000006281	STK3
9		EKS-TUT-00082	ENSTTRG00000004503	MYO3B
10		EKS-TUT-00074	ENSTTRG00000016919	MAP4K4
11		EKS-TUT-00078	ENSTTRG00000000040	PAK6
12		EKS-TUT-00083	ENSTTRG00000009309	STRADB