※ Eph family introduction

    Eph receptor tyrosine kinases are known able to bind their ephrin ligands and act as key regulator of cell contact-dependent signaling and patterning. Eph kinase contains fourteen members which can further be classified into two subclasses A and B in human. EphA1-8 and Eph10 belong to subclass A, EphB1-4 and EphB6 belong to subclass B. Eph kinases consist of two regions: intracellular region and extracellular region. The extracellular part contains a globular ligand-binding domain, a cysteine-rich region and two fibronectin type III repeats. The intracellular part contains a short juxtamembrane region, a kinase catalytic domain, a sterile α motif (SAM) protein−protein interaction domain and a PDZ-binding motif. Eph/ephrin binding will lead to very diverse biological readouts including adhesion versus repulsion and increased versus decreased motility. Depending on the different cell type and context, the interaction will lead to different downstream signaling pathway. In addition, evidence shows that endocytosis of Eph/ephrin and associated tissue-specific effectors are essential for diverse biological roles and processes (1).

Reference
1. Pitulescu, M.E. and Adams, R.H. (2010) Eph/ephrin molecules--a hub for signaling and endocytosis. Genes Dev, 24, 2480-2492. PMID: 21078817

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-FEC-00004	ENSFCAG00000024008	EPHA3
2		EKS-FEC-00012	ENSFCAG00000023114
3		EKS-FEC-00006	ENSFCAG00000006852	EPHB4
4		EKS-FEC-00009	ENSFCAG00000007281	EPHA1
5		EKS-FEC-00001	ENSFCAG00000007712	EPHA4
6		EKS-FEC-00011	ENSFCAG00000008764	EPHA10
7		EKS-FEC-00005	ENSFCAG00000008818	EPHB3
8		EKS-FEC-00008	ENSFCAG00000026563	EPHA8
9		EKS-FEC-00003	ENSFCAG00000000544	EPHB1
10		EKS-FEC-00002	ENSFCAG00000018481	EPHA7
11		EKS-FEC-00010	ENSFCAG00000014929	EPHB6
12		EKS-FEC-00007	ENSFCAG00000010170	EPHA2