※ Src family introduction

    Src family kinases, also caller SFK, are receptor tyrosine protein kinase and play an essential role in regulation of signal transduction form cell surface to cytoplasm. SFK members share a conserved domain structure, including a myristoylated N-terminal segment, a SH3, SH2, linker, followed by a tyrosine kinase domain and a C-terminal short tail. The intact state of SFKs are catalytic inactive, and how these kinase assemble into a active signaling complexes with others proteins is still unresolved. SFKs can mediate the transduction of signal and regulate specialized cellular functions. In central nervous system (CNS), SFKs have been found widely expressed and are involved in proliferation and differentiation of CNS through upregulating the activity of NMDA receptors and other ion channels. In T-cell antigen receptor signal transduction, SFKs interact with TCR via association with CD4 and CD8 co-receptor, Unc119 and so on, which will regulate the proliferation of T cells. SFKs are also involved in initiating signal transductino via the B-cell antigen receptor. The function loss of SFKs will lead to the defects in B-cell development and autoimmunity (1).

Reference
1. Parsons, S.J. and Parsons, J.T. (2004) Src family kinases, key regulators of signal transduction. Oncogene, 23, 7906-7909. PMID: 15489908.

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-FEC-00353	ENSFCAG00000023350	FYN
2		EKS-FEC-00354	ENSFCAG00000006991	SRC
3		EKS-FEC-00363	ENSFCAG00000023614
4		EKS-FEC-00358	ENSFCAG00000012482	LCK
5		EKS-FEC-00356	ENSFCAG00000001904	HCK
6		EKS-FEC-00357	ENSFCAG00000007868	FGR
7		EKS-FEC-00361	ENSFCAG00000008678	SRMS
8		EKS-FEC-00362	ENSFCAG00000008925	PTK6
9		EKS-FEC-00360	ENSFCAG00000004043	FRK
10		EKS-FEC-00359	ENSFCAG00000014872	BLK
11		EKS-FEC-00355	ENSFCAG00000009235	YES1