※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

  Reviewed (2)  or Unreviewed (21) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ART-01025	AT2G17700	AT2G17700; At2g17700
2		EKS-ART-01024	AT5G11850	AT5G11850; At5g11850
3		EKS-ART-01028	AT2G24360	At2g24360; AT2G24360
4		EKS-ART-01026	AT1G62400	At1g62400; F24O1.13; HT1
5		EKS-ART-01030	AT4G31170	AT4G31170; AT4g31170; At4g31170
6		EKS-ART-01023	AT4G35780	At4g35780; AT4G35780
7		EKS-ART-01044	AT2G35050	AT2G35050; At2g35050
8		EKS-ART-01032	AT4G23050	AT4G23050; AT4g23050; F7H19.240; At4g23050
9		EKS-ART-01045	AT5G40540	At5g40540; AT5G40540
10		EKS-ART-01029	AT1G73660	AT1G73660; At1g73660
11		EKS-ART-01038	AT5G57610	AT5G57610; At5g57610
12		EKS-ART-01039	AT1G16270	AT1G16270; F3O9.7; At1g16270
13		EKS-ART-01042	AT3G24715	At3g24715; AT3G24715
14		EKS-ART-01035	AT2G42640	AT2G42640; At2g42640
15		EKS-ART-01037	AT5G50180	AT5G50180; At5g50180
16		EKS-ART-01031	AT5G58950	AT5G58950
17		EKS-ART-01027	AT5G03730	At5g03730; F17C15_150; CTR1; AtCTR1
18		EKS-ART-01041	AT3G27560	ATN1
19		EKS-ART-01040	AT3G46920	T6H20.50; AT3G46920; At3g46920
20		EKS-ART-01034	AT3G46930	AT3G46930; T6H20.40; At3g46930
21		EKS-ART-01033	AT1G08720	EDR1
22		EKS-ART-01043	AT1G79570	T8K14.1; At1g79570; AT1G79570
23		EKS-ART-01036	AT1G04700	AT1G04700; At1g04700