※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-FEC-00371	ENSFCAG00000028243	MAP3K13
2		EKS-FEC-00369	ENSFCAG00000030907	MAP3K7
3		EKS-FEC-00365	ENSFCAG00000006618	MAP3K9
4		EKS-FEC-00366	ENSFCAG00000012177	MAP3K10
5		EKS-FEC-00368	ENSFCAG00000012780	MAP3K12
6		EKS-FEC-00364	ENSFCAG00000005689	MAP3K11
7		EKS-FEC-00367	ENSFCAG00000008059
8		EKS-FEC-00372	ENSFCAG00000009652
9		EKS-FEC-00370	ENSFCAG00000015388	ILK