※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-LOA-00391	ENSLAFG00000011342	LOC100674156
2		EKS-LOA-00387	ENSLAFG00000017140	LOC100660454
3		EKS-LOA-00385	ENSLAFG00000000758	MAP3K11
4		EKS-LOA-00388	ENSLAFG00000002204	MAP3K10
5		EKS-LOA-00384	ENSLAFG00000018561	MAP3K9
6		EKS-LOA-00390	ENSLAFG00000018639	MAP3K7
7		EKS-LOA-00392	ENSLAFG00000014337	ILK
8		EKS-LOA-00393	ENSLAFG00000001764
9		EKS-LOA-00389	ENSLAFG00000002616	MAP3K12
10		EKS-LOA-00386	ENSLAFG00000002531	MAP3K13