※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

  Reviewed (0)  or Unreviewed (16) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PHP-00752	PP1S85_87V6	PHYPADRAFT_16276; A9SJL3_PHYPA
2		EKS-PHP-00744	PP1S120_103V6	A9SUI7_PHYPA; PHYPADRAFT_135466
3		EKS-PHP-00750	PP1S19_317V6	PHYPADRAFT_117260; A9RNX8_PHYPA
4		EKS-PHP-00757	PP1S178_41V6	A9T7F9_PHYPA; PHYPADRAFT_141466
5		EKS-PHP-00742	PP1S43_196V6	A9S2K7_PHYPA; PHYPADRAFT_123192
6		EKS-PHP-00743	PP1S17_22V6	PHYPADRAFT_203860; A9RMB5_PHYPA
7		EKS-PHP-00746	PP1S69_199V6	PHYPADRAFT_128329; A9SE57_PHYPA
8		EKS-PHP-00747	PP1S31_3V6	PHYPADRAFT_178475; A9RVT3_PHYPA
9		EKS-PHP-00753	PP1S66_220V6	A9SCX4_PHYPA; PHYPADRAFT_106226
10		EKS-PHP-00751	PP1S126_60V6
11		EKS-PHP-00745	PP1S130_99V6
12		EKS-PHP-00756	PP1S248_25V6	PHYPADRAFT_223038; A9TK23_PHYPA
13		EKS-PHP-00755	PP1S131_116V6	A9SX50_PHYPA; PHYPADRAFT_136776
14		EKS-PHP-00748	PP1S244_9V6	PHYPADRAFT_146497; A9TJD7_PHYPA
15		EKS-PHP-00749	PP1S172_82V6	A9T6C5_PHYPA; PHYPADRAFT_140928
16		EKS-PHP-00754	PP1S78_106V6	PHYPADRAFT_106434; A9SH42_PHYPA