※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SEM-01039	SELMODRAFT_146775	SELMODRAFT_146775
2		EKS-SEM-01043	SELMODRAFT_63609	SELMODRAFT_63609
3		EKS-SEM-01044	SELMODRAFT_43546	SELMODRAFT_43546
4		EKS-SEM-01037	SELMODRAFT_40493	SELMODRAFT_40493
5		EKS-SEM-01038	SELMODRAFT_269874	SELMODRAFT_269874
6		EKS-SEM-01033	SELMODRAFT_40986	SELMODRAFT_40986; CTR1L1-2
7		EKS-SEM-01040	SELMODRAFT_157107	SELMODRAFT_157107
8		EKS-SEM-01041	SELMODRAFT_20996	SELMODRAFT_20996
9		EKS-SEM-01035	SELMODRAFT_120027	SELMODRAFT_120027
10		EKS-SEM-01036	SELMODRAFT_97070	SELMODRAFT_97070
11		EKS-SEM-01045	SELMODRAFT_115084	SELMODRAFT_115084; SELMODRAFT_115084, SELMODRAFT_88196
12		EKS-SEM-01042	SELMODRAFT_932	SELMODRAFT_932
13		EKS-SEM-01031	SELMODRAFT_271762	SELMODRAFT_271762; SELMODRAFT_146897, SELMODRAFT_271762
14		EKS-SEM-01034	SELMODRAFT_10499	CTR1L1-1; SELMODRAFT_10499
15		EKS-SEM-01046	SELMODRAFT_155162	SELMODRAFT_155162
16		EKS-SEM-01032	SELMODRAFT_46485	SELMODRAFT_46485