※ MLK family introduction

    MLKs (Mixed-lineage kinases) are ser/thr protein kinases which are involved in regulation of JNK and p38 MAPK pathways. MLKs contains threes subfamily, MLK, DLK and ZAK. MLK subfamily is characterized by an N-terminal SH3 domain, followed by a protein kinase domain, a leucine-zipper region and a CRIB motif. DLK subfamily contains a kinase domain and two leucine-zipper motifs. ZAK subfamily consists of a kinase domain and a SAM domain. MLKs play an important role in regulation of JNK pathways in mammalian cells which will result in diverse biological processes, including cellular transformation, activation of NF-kB pathways, neuronal apoptosis and so on (1).

Reference
1. Gallo, K.A. and Johnson, G.L. (2002) Mixed-lineage kinase control of JNK and p38 MAPK pathways. Nat Rev Mol Cell Biol, 3, 663-672. PMID: 12209126

  Reviewed (0)  or Unreviewed (25) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SEI-01310	Si034063m.g	Si034063m.g
2		EKS-SEI-01323	Si017658m.g	Si017658m.g
3		EKS-SEI-01315	Si028893m.g	Si028893m.g
4		EKS-SEI-01303	Si001885m.g	Si001885m.g
5		EKS-SEI-01305	Si017293m.g	Si017293m.g
6		EKS-SEI-01313	Si000760m.g	Si000760m.g
7		EKS-SEI-01318	Si035834m.g	Si035834m.g
8		EKS-SEI-01301	Si016333m.g	Si016333m.g
9		EKS-SEI-01307	Si005743m.g	Si005743m.g
10		EKS-SEI-01311	Si034087m.g	Si034087m.g
11		EKS-SEI-01316	Si030660m.g	Si030660m.g
12		EKS-SEI-01317	Si021033m.g	Si021033m.g
13		EKS-SEI-01302	Si029013m.g	Si029013m.g
14		EKS-SEI-01304	Si016301m.g	Si016301m.g
15		EKS-SEI-01319	Si029030m.g	Si029030m.g
16		EKS-SEI-01320	Si005722m.g	Si005722m.g
17		EKS-SEI-01312	Si000750m.g	Si000750m.g
18		EKS-SEI-01308	Si016157m.g	Si016157m.g
19		EKS-SEI-01314	Si021527m.g	Si021527m.g
20		EKS-SEI-01321	Si005733m.g	Si005733m.g
21		EKS-SEI-01325	Si034839m.g	Si034839m.g
22		EKS-SEI-01309	Si029452m.g	Si029452m.g
23		EKS-SEI-01324	Si008355m.g	Si008355m.g
24		EKS-SEI-01322	Si016154m.g	Si016154m.g
25		EKS-SEI-01306	Si010212m.g	Si010212m.g