※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (15) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ORL-00337	ENSORLG00000013834
2		EKS-ORL-00333	ENSORLG00000005565	BMPR1B (1 of 2)
3		EKS-ORL-00339	ENSORLG00000000099	Q90ZR4_ORYLA; ACVR2
4		EKS-ORL-00332	ENSORLG00000016705	ACVR1C
5		EKS-ORL-00334	ENSORLG00000016722	ACVR1
6		EKS-ORL-00341	ENSORLG00000003784	ACVR2B (2 of 2); ACVR2B (1 of 2)
7		EKS-ORL-00335	ENSORLG00000007833	BMPR1B (2 of 2)
8		EKS-ORL-00342	ENSORLG00000003034	BMPR2
9		EKS-ORL-00331	ENSORLG00000007566	ACVR1B
10		EKS-ORL-00338	ENSORLG00000007548	ACVRL1
11		EKS-ORL-00344	ENSORLG00000009191	Ola.18944; misrii
12		EKS-ORL-00340	ENSORLG00000019706	ACVR2B (1 of 2); ACVR2B (2 of 2)
13		EKS-ORL-00343	ENSORLG00000014158	TGFBR2
14		EKS-ORL-00336	ENSORLG00000002596	BMPR1A
15		EKS-ORL-00330	ENSORLG00000018380	TGFBR1