※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PES-00252	ENSPSIG00000008392	ACVR2B
2		EKS-PES-00246	ENSPSIG00000009530	ACVR1
3		EKS-PES-00248	ENSPSIG00000009445	ACVR1C
4		EKS-PES-00244	ENSPSIG00000018059	TGFBR1
5		EKS-PES-00253	ENSPSIG00000005251	TGFBR2
6		EKS-PES-00247	ENSPSIG00000005496	BMPR1B
7		EKS-PES-00251	ENSPSIG00000017364	ACVR2A
8		EKS-PES-00245	ENSPSIG00000017901	ACVR1B
9		EKS-PES-00250	ENSPSIG00000017730	ACVRL1
10		EKS-PES-00254	ENSPSIG00000013650	BMPR2
11		EKS-PES-00249	ENSPSIG00000007367	BMPR1A
12		EKS-PES-00255	ENSPSIG00000003577