※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (14) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PEM-00153	ENSPMAG00000007549	BMPR2 (1 of 2)
2		EKS-PEM-00159	ENSPMAG00000007769
3		EKS-PEM-00146	ENSPMAG00000003465
4		EKS-PEM-00151	ENSPMAG00000001560
5		EKS-PEM-00155	ENSPMAG00000006614	BMPR2 (2 of 2)
6		EKS-PEM-00147	ENSPMAG00000006321	ACVR1B
7		EKS-PEM-00150	ENSPMAG00000006293	ACVR1 (2 of 2)
8		EKS-PEM-00152	ENSPMAG00000000933
9		EKS-PEM-00156	ENSPMAG00000000948	BMPR1B
10		EKS-PEM-00149	ENSPMAG00000005274	ACVR1 (1 of 2)
11		EKS-PEM-00148	ENSPMAG00000005387	TGFBR1
12		EKS-PEM-00157	ENSPMAG00000005779
13		EKS-PEM-00154	ENSPMAG00000008747	TGFBR2
14		EKS-PEM-00158	ENSPMAG00000008794	ACVR2A