※ STKR family introduction

    STKR are serine/threonine kinase receptor comprising two subfamily, TGFb receptors and activin receptors. TGFb receptors contain different isoforms which are homo- or heterodimeric. The mediate the interaction between ligand and receptor. TGFb receptors are expressed in diverse tissues, including heart, liver, kidney, brain and testes. TGFb receptor can be further classified into three subclasses from type1 to type3. Abnormal expression of TGFb receptor leads to renal fibrosis which will result in kidney disease. Diabetes is also found to be associated with TGFb receptor (1). Another subfamily is activin receptors, which are characterized by its feature to bind activin. The activin receptors contain a transmembrane domain and a hydrophilic Cys-rich ligand-binding domain (2).

Reference
1. Wikipedia annotation: TGF beta receptors
2. Wikipedia annotation: Activin receptor

  Reviewed (0)  or Unreviewed (18) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-XIM-00357	ENSXMAG00000000721	ACVR2B (1 of 2)
2		EKS-XIM-00353	ENSXMAG00000009996
3		EKS-XIM-00365	ENSXMAG00000000566	TGFBR1
4		EKS-XIM-00354	ENSXMAG00000004259	BMPR1A
5		EKS-XIM-00356	ENSXMAG00000010594	ACVR2A (1 of 2)
6		EKS-XIM-00355	ENSXMAG00000011072	ACVRL1
7		EKS-XIM-00348	ENSXMAG00000011075	ACVR1B
8		EKS-XIM-00349	ENSXMAG00000011304	ACVR1C
9		EKS-XIM-00350	ENSXMAG00000011317	ACVR1
10		EKS-XIM-00364	ENSXMAG00000007463	AMHR2
11		EKS-XIM-00359	ENSXMAG00000014092	ACVR2B (2 of 2)
12		EKS-XIM-00361	ENSXMAG00000014367	TGFBR2 (1 of 2)
13		EKS-XIM-00358	ENSXMAG00000002106	ACVR2A (2 of 2)
14		EKS-XIM-00362	ENSXMAG00000002747	TGFBR2 (2 of 2)
15		EKS-XIM-00352	ENSXMAG00000001635	BMPR1B (2 of 2)
16		EKS-XIM-00363	ENSXMAG00000013681	BMPR2 (2 of 2)
17		EKS-XIM-00360	ENSXMAG00000013725	BMPR2 (1 of 2)
18		EKS-XIM-00351	ENSXMAG00000017124	BMPR1B (1 of 2)