EKS-ORL-00426

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00426

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tie	525.7	2.8E-158	842	1088	247

Status

Unreviewed

Ensembl Protein

ENSORLP00000013414

UniProt Accession

H2M4P5;

Protein Name

Protein Synonyms/Alias

Gene Name

TIE1

Gene Synonyms/Alias

TIE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000010699	ENSORLP00000013414	ENSORLT00000013415

Organism

Oryzias latipes

Functional Description

Protein Length

1140

Protein Sequence
(FASTA)

KLFTLPPLKT SILTLASTCP LDAVIDLTMI STAEVIRVNH FTISCINGEH SSAQVKLDIK 60

RDNKILILSK ETSFKVHKQD NRHVIARDFR ALDNIGIFYC ESTQSNSPLE KVTMINNFGT 120

TNFVPTSLTM TVNKGETVHL NMLLLSSEKR DVTWKYNGNY YYMTHWNDVL NRTATLTVEN 180

AAFANQGIYS ASYVGDSPLH GAWMRLIVRD CPSKKWGSYC ERDCPDCLNG GICHDAEGDC 240

VCPPGFMGTR CETACREGMF GQNCQESCRS DSNNNCRGLR FCLPDPYGCS CASGWFGHRC 300

EKACLNDRYG PDCRLSCKCQ NGGICSRFRG CQCPAGWRGQ NCEKSDRAPQ ILGLDSDPEW 360

NLNSSPKISC LATGNPPPSH NSIELRRSDN IVLKPTRTTM DSNKSIALFE IPHLSAKEQG 420

LWECRVSTNG GQDSLKFNLT IKEPPVPIGP PKLLERGSKQ LLVLPATSHK GDGPIISTRV 480

LYKPDTNGDS WSSVIVYNKE PITLMNLEPS TKYRIRVQLS RPGAGGEGAE GPEETMETDC 540

PAAEPTIQPE IDTSSVEGRN VTVRWRLPPN TVITSDTATG FLVQLSTPPP HNEKLLEETT 600

LLKVLSTKFH NLEYHQTYTV VVRLVNCGSH GPLSKPYRFR INSQGPSSPR NVEALPLSMS 660

SIQVKWLPPE NPNGGIIKYI IEYQAIGQGN PHPWVDTDDG NKTTKDVTAL NSSTVYQFRV 720

RAFSKVPGEW SKFVKATTQG DDYENSIPTT QGVAGKPAGD GYQLLLAVVG SVTVTSAVIM 780

LVLLALFFIR KTLVNRRRTF TYQSGSGEET ILQFNSGTLT LSRRPKPTPE PLTYPILEWE 840

DIKFEDVIGE GNFGQVIKAM IKKDGSKISA AIKMLKEFAS ENDHRDFAGE LEVLCKLGHH 900

PNIINLIGAC ENRGYLYIAI EYAPYGNLLD FLRKSRVLET DPAFAKEHGT ASTLTSQQLL 960

QFAVDVATGM HYLSDKQFIH RDLAARNVLV GDNLVAKIAD FGLSRGEEVY VKKTMGRLPV 1020

RWMAIESLNY SVYTTKSDVW SFGVLLWEIV SLGGTPYCGM TCAELYEKLP QGYRMEKPKN 1080

CGTKIYGNYI AQYYNKSHLK GLQTGSWVIN MNHKEHKAYV NMALFENFTY AGIDATAEKA 1140

Nucleotide Sequence
(FASTA)

AAGCTGTTTA CGTTGCCACC TTTAAAAACA TCAATCTTGA CACTTGCTTC AACCTGTCCT 60

TTAGATGCTG TGATCGACTT GACCATGATC TCCACAGCAG AGGTCATCCG GGTCAACCAC 120

TTCACCATAT CATGCATAAA TGGAGAACAC AGCTCGGCTC AGGTCAAGCT GGATATCAAG 180

AGGGACAACA AGATTCTCAT TTTGTCTAAA GAGACAAGTT TTAAAGTACA CAAGCAGGAC 240

AACAGGCATG TGATTGCCAG AGATTTCCGG GCACTAGATA ATATTGGCAT CTTCTATTGT 300

GAATCTACCC AAAGCAATTC TCCACTTGAG AAAGTCACCA TGATCAACAA CTTTGGCACA 360

ACTAATTTTG TTCCAACATC CCTTACAATG ACTGTAAACA AAGGAGAGAC GGTTCACCTA 420

AACATGCTGC TCCTCAGCTC TGAAAAGAGA GATGTGACTT GGAAGTACAA TGGAAATTAC 480

TATTACATGA CTCACTGGAA TGATGTGCTC AATCGCACTG CAACACTGAC TGTGGAGAAC 540

GCTGCATTCG CCAATCAAGG CATCTACAGC GCCAGCTACG TCGGGGACAG TCCTCTGCAT 600

GGCGCCTGGA TGAGGCTTAT TGTCAGAGAT TGTCCCAGTA AGAAGTGGGG TTCCTACTGT 660

GAGAGGGATT GTCCAGACTG TCTCAATGGT GGAATTTGTC ACGATGCAGA AGGAGACTGT 720

GTGTGTCCTC CAGGATTCAT GGGAACACGC TGTGAGACAG CCTGCAGGGA AGGAATGTTT 780

GGTCAAAACT GCCAGGAGTC CTGCAGGTCT GACTCAAACA ATAACTGCAG AGGGCTTCGT 840

TTCTGCCTAC CAGATCCATA TGGTTGCTCC TGTGCCAGCG GTTGGTTTGG ACACCGCTGT 900

GAAAAAGCCT GTCTTAATGA CAGGTATGGA CCAGACTGCA GGCTGAGTTG CAAATGCCAG 960

AACGGAGGGA TCTGCAGTCG TTTTAGAGGA TGTCAGTGTC CGGCAGGATG GCGAGGGCAG 1020

AACTGTGAGA AGTCAGACCG GGCTCCTCAG ATTTTAGGCT TGGATTCTGA TCCGGAGTGG 1080

AATCTGAACT CCAGCCCCAA GATCTCTTGT TTGGCCACAG GCAACCCACC GCCCAGCCAC 1140

AACAGCATTG AGCTGCGTCG ATCGGACAAT ATTGTGCTCA AGCCAACAAG AACAACCATG 1200

GACTCAAACA AGAGCATAGC CCTGTTTGAA ATCCCTCACC TGAGTGCAAA GGAGCAAGGC 1260

CTGTGGGAGT GTAGGGTCTC CACCAATGGG GGTCAAGACT CACTAAAGTT CAATCTTACT 1320

ATTAAAGAGC CCCCAGTTCC TATTGGTCCT CCCAAACTGT TAGAGAGGGG TAGTAAGCAG 1380

CTGCTGGTGT TGCCAGCAAC ATCCCACAAA GGAGATGGCC CCATAATCTC AACAAGAGTC 1440

CTTTACAAGC CGGACACCAA TGGAGACTCT TGGTCCTCAG TCATAGTTTA TAACAAAGAG 1500

CCCATCACGC TGATGAATCT GGAGCCTTCC ACAAAATACC GCATTCGGGT CCAGCTGAGT 1560

CGTCCTGGGG CTGGAGGAGA GGGGGCTGAA GGGCCAGAGG AAACCATGGA GACGGACTGT 1620

CCCGCTGCAG AGCCCACAAT TCAACCTGAG ATTGACACCA GCTCAGTGGA GGGCCGCAAT 1680

GTTACTGTTC GATGGCGACT TCCCCCCAAC ACCGTCATTA CTTCCGACAC AGCAACCGGC 1740

TTTTTAGTGC AGCTCTCCAC TCCTCCACCC CACAATGAGA AACTGCTGGA GGAGACCACT 1800

TTGCTCAAGG TGCTCTCCAC CAAGTTCCAC AACCTGGAGT ATCATCAAAC CTACACTGTG 1860

GTGGTGCGCC TCGTCAACTG TGGCAGCCAC GGGCCACTCT CCAAGCCCTA CCGCTTCCGC 1920

ATCAACAGCC AGGGACCGTC GTCCCCACGC AACGTTGAAG CCCTGCCCCT CTCCATGTCC 1980

TCCATCCAGG TGAAGTGGCT GCCCCCTGAG AATCCAAACG GAGGCATCAT TAAGTACATC 2040

ATTGAGTACC AGGCCATTGG TCAAGGAAAT CCTCACCCCT GGGTGGATAC AGATGATGGT 2100

AACAAGACCA CCAAGGATGT GACAGCCCTA AACAGCAGCA CGGTCTATCA ATTTAGAGTA 2160

AGGGCTTTCT CCAAAGTGCC TGGAGAGTGG AGCAAGTTTG TGAAAGCAAC AACTCAAGGG 2220

GATGACTATG AGAATTCAAT TCCCACCACC CAGGGTGTTG CTGGTAAGCC TGCTGGAGAT 2280

GGTTACCAGC TGCTGTTGGC AGTGGTGGGC TCGGTGACTG TTACCTCCGC GGTCATAATG 2340

CTGGTACTGC TAGCTCTGTT CTTCATCAGG AAAACCCTGG TCAATCGCCG GCGTACGTTC 2400

ACCTACCAGT CTGGATCGGG AGAAGAAACT ATTTTGCAGT TTAACTCAGG AACTTTGACC 2460

CTCTCCAGAA GGCCTAAGCC AACGCCGGAA CCTCTCACCT ATCCAATTCT TGAGTGGGAG 2520

GACATAAAAT TTGAAGATGT CATTGGGGAG GGCAATTTTG GCCAAGTCAT TAAAGCCATG 2580

ATTAAAAAGG ATGGCAGCAA AATAAGTGCA GCAATCAAGA TGCTAAAGGA GTTTGCTTCA 2640

GAGAATGACC ACAGAGACTT TGCAGGAGAG CTGGAGGTGC TTTGCAAACT AGGACATCAT 2700

CCCAACATCA TTAATTTGAT TGGAGCCTGT GAAAACAGGG GCTATCTGTA CATCGCTATA 2760

GAATATGCTC CCTACGGTAA CCTGCTTGAT TTCCTAAGGA AGAGCAGAGT GCTGGAGACT 2820

GACCCTGCTT TTGCCAAAGA GCACGGGACA GCTTCCACAC TTACATCTCA GCAGCTTCTA 2880

CAGTTTGCTG TGGACGTAGC TACTGGGATG CATTACCTCA GTGATAAACA GTTCATCCAC 2940

AGGGATTTGG CAGCAAGGAA TGTTCTTGTG GGGGACAACC TTGTGGCAAA GATAGCGGAT 3000

TTTGGTCTGT CCCGCGGTGA GGAAGTTTAT GTGAAGAAGA CAATGGGGAG GCTACCAGTG 3060

CGCTGGATGG CCATTGAATC CCTAAATTAC AGTGTATACA CAACCAAGAG TGATGTGTGG 3120

TCTTTTGGTG TTCTTCTGTG GGAAATTGTA AGCTTAGGTG GCACACCATA CTGTGGGATG 3180

ACCTGTGCTG AGCTCTATGA AAAACTGCCA CAGGGTTACA GAATGGAGAA ACCCAAAAAC 3240

TGTGGCACAA AGATTTATGG AAATTATATA GCCCAATATT ACAACAAAAG TCATCTCAAG 3300

GGGCTTCAAA CCGGTAGTTG GGTAATAAAC ATGAACCATA AAGAACATAA AGCTTATGTG 3360

AACATGGCTT TGTTTGAGAA CTTCACCTAT GCTGGAATAG ATGCCACCGC AGAGAAGGCC 3420

TGA 3423

Domain Profile

S: 1     ikfedligegnfgqvlkarikkdglkmdaaikrlkeyaskddhrdfagelevlcklghhp  60

         ikfed+igegnfgqv+ka+ikkdg k+ aaik+lke+as++dhrdfagelevlcklghhp

Q: 842   IKFEDVIGEGNFGQVIKAMIKKDGSKISAAIKMLKEFASENDHRDFAGELEVLCKLGHHP  901

         89**********************************************************

S: 61    niinllgacenrgylylaieyapygnlldflrksrvletdpafaienstastlssrqllr  120

         niinl+gacenrgyly+aieyapygnlldflrksrvletdpafa+e++tastl+s+qll+

Q: 902   NIINLIGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAKEHGTASTLTSQQLLQ  961

         ************************************************************

S: 121   faadvargmdylsekqfihrdlaarnvlvgenlvakiadfglsrgeevyvkktmgrlpvr  180

         fa dva gm+yls+kqfihrdlaarnvlvg+nlvakiadfglsrgeevyvkktmgrlpvr

Q: 962   FAVDVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSRGEEVYVKKTMGRLPVR  1021

         ************************************************************

S: 181   wmaieslnysvyttksdvwsygvllweivslggtpycgmtcaelyeklpqgyrlekplnc  240

         wmaieslnysvyttksdvws+gvllweivslggtpycgmtcaelyeklpqgyr+ekp+nc

Q: 1022  WMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEKPKNC  1081

         ************************************************************

S: 241   ddevyel  247

++y

Q: 1082  GTKIYGN  1088

         ****964

Domain Sequence
(FASTA)

IKFEDVIGEG NFGQVIKAMI KKDGSKISAA IKMLKEFASE NDHRDFAGEL EVLCKLGHHP 60

NIINLIGACE NRGYLYIAIE YAPYGNLLDF LRKSRVLETD PAFAKEHGTA STLTSQQLLQ 120

FAVDVATGMH YLSDKQFIHR DLAARNVLVG DNLVAKIADF GLSRGEEVYV KKTMGRLPVR 180

WMAIESLNYS VYTTKSDVWS FGVLLWEIVS LGGTPYCGMT CAELYEKLPQ GYRMEKPKNC 240

GTKIYGN 247

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR000742	; EG-like_dom.
IPR013032	; EGF-like_CS.
IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00181	; EGF; 3.
SM00060	; FN3; 3.
SM00219	; TyrKc; 1.

Prosites

PS00022	; EGF_1; 3.
PS01186	; EGF_2; 3.
PS50026	; EGF_3; 2.
PS50853	; FN3; 3.
PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013