EKS-TAG-00195

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAG-00195

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	483.3	1.3E-145	442	700	259

Status

Unreviewed

Ensembl Protein

ENSTGUP00000002960

UniProt Accession

H0YXD4;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG2

Gene Synonyms/Alias

PRKG2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTGUG00000002872	ENSTGUP00000002960	ENSTGUT00000002989

Organism

Taeniopygia guttata

Functional Description

Protein Length

751

Protein Sequence
(FASTA)

MGNRLVKPKH LRQPNRHMAN LAIGSDVLCS KVLELEKELK RKDQQLQESQ HHVAELQEQL 60

AMQTKVIAEL SNELQSKCIQ LNKLQDVIST QGEHSLQPSP FKVSADRRRG AKEGVSAEPT 120

TALCDLSRQT MFSLEKATVQ KDSSEKKLIT DALNRNQFLK RLEPHQTRDM VECMYERTFQ 180

QGSYVIRQGE PGNHIFVLKE GSLEVFQQNK LLSSIPVWTA FGELAILYNC TRTASVKAIT 240

NVKTWALDRE VFQNIMRVTA QTRQEQYRKF LRSVSLLKNL PEDKLTKIMD CLEVEYYDKG 300

DYVIREGEEG NTFFIIAKGK VIVTQSTTDH SQPQVIKNLH KGDYFGEKAL ISDDTRSANV 360

IADEYNVECL VIDRETFNQT VGTYEELQTY LEGYVANLAQ ADEKRHAKGR SFCGQLTKEV 420

SLEMIELKEK VAQFPPSPFQ NLEVVTTLGV GGFGRVELVK VKNENMAFAM KCIKKKHVVD 480

TKQQEHIYSE KKILEQICSP FVVKLYRTFK DNKYVYMLLE ACLGGELWSL LRDRGSFDEF 540

TTKFCVGCVT EAFDYLHQIG IIYRDLKPEN LILDAEGYIK LVDFGFAKKI GSGQKTWTFC 600

GTPEYVAPEV ILSKGHDFSV DFWSLGILVY ELLTGSPPFS GADQMMTYNL ILKGIEKLDF 660

PKVITRRPED LIRRLCRQNP TERLGNLRNG INDIKKHRWL SGFNWDSLKV RKLTSPLKRE 720

LSGPTDYSYF DSYPPEVGSP PDELSGWDKD F 751

Nucleotide Sequence
(FASTA)

ATGGGGAACA GACTAGTGAA ACCTAAGCAC CTGAGGCAGC CGAATAGGCA CATGGCAAAC 60

CTTGCTATTG GCTCTGATGT CCTCTGCAGC AAGGTACTTG AACTGGAAAA GGAGCTGAAG 120

AGAAAAGATC AGCAGTTGCA GGAGAGTCAA CACCATGTTG CTGAGCTTCA GGAACAGCTG 180

GCTATGCAGA CTAAGGTCAT AGCAGAACTC AGCAATGAGC TTCAGAGCAA GTGCATACAG 240

TTGAACAAGC TGCAGGATGT TATTAGCACT CAAGGAGAGC ACTCTCTTCA GCCTTCTCCA 300

TTTAAAGTTT CTGCTGACAG GAGGAGAGGA GCCAAGGAAG GCGTATCTGC AGAGCCAACA 360

ACAGCACTGT GCGATTTGAG CAGGCAAACT ATGTTTTCCC TTGAAAAAGC AACAGTCCAA 420

AAGGATTCCA GTGAGAAGAA GCTTATCACA GATGCCCTGA ATAGAAACCA GTTCCTGAAG 480

AGACTGGAGC CTCACCAGAC ACGAGACATG GTGGAATGTA TGTATGAGAG GACGTTCCAG 540

CAAGGAAGCT ATGTCATCAG ACAGGGAGAA CCGGGAAATC ACATTTTTGT GCTCAAAGAG 600

GGCAGTCTGG AAGTCTTTCA GCAGAATAAG CTACTCTCCT CAATACCTGT GTGGACAGCG 660

TTCGGTGAAC TGGCCATTTT ATACAACTGC ACACGGACAG CTTCTGTGAA AGCAATCACT 720

AATGTTAAAA CATGGGCACT GGACAGAGAA GTGTTTCAAA ATATCATGAG AGTGACAGCA 780

CAAACCAGAC AAGAGCAGTA CAGAAAGTTC CTTAGAAGTG TGTCCCTGCT GAAAAACTTA 840

CCTGAAGATA AATTAACCAA GATTATGGAC TGCCTGGAAG TGGAGTATTA TGACAAGGGA 900

GATTACGTTA TTCGGGAAGG AGAAGAAGGA AACACCTTCT TTATAATAGC AAAAGGAAAG 960

GTGATAGTTA CCCAGAGTAC TACAGACCAC TCGCAGCCTC AGGTGATTAA AAATCTACAC 1020

AAAGGAGATT ACTTTGGAGA AAAGGCTCTC ATTAGTGATG ACACCAGATC AGCAAACGTT 1080

ATTGCAGATG AGTACAACGT GGAGTGCCTT GTTATAGACA GAGAGACATT TAATCAGACT 1140

GTTGGAACTT ATGAGGAGCT GCAAACTTAC CTGGAAGGTT ATGTGGCCAA TCTGGCCCAG 1200

GCTGATGAAA AGCGACATGC AAAAGGAAGA TCCTTCTGTG GACAGTTGAC CAAAGAGGTG 1260

TCTTTGGAGA TGATAGAGCT GAAGGAGAAA GTAGCCCAGT TCCCTCCTTC CCCATTCCAG 1320

AATTTAGAAG TTGTCACGAC CCTGGGTGTT GGTGGGTTCG GAAGGGTTGA GCTTGTTAAA 1380

GTTAAAAATG AGAACATGGC TTTTGCTATG AAATGTATAA AGAAGAAACA TGTAGTGGAC 1440

ACCAAACAGC AAGAGCATAT CTATTCTGAG AAGAAAATCC TTGAGCAGAT ATGTTCTCCA 1500

TTTGTTGTAA AGCTGTATCG CACATTCAAG GATAATAAAT ATGTGTACAT GCTCCTGGAG 1560

GCTTGCCTTG GAGGGGAATT ATGGAGCTTG CTGAGAGACA GAGGCAGCTT TGATGAATTC 1620

ACCACAAAGT TTTGTGTTGG GTGTGTGACA GAGGCTTTTG ACTATCTGCA TCAAATAGGA 1680

ATTATCTACA GAGACCTGAA GCCAGAAAAT TTAATTTTGG ATGCTGAAGG ATATATAAAA 1740

TTGGTTGATT TTGGATTTGC AAAGAAGATT GGATCAGGGC AGAAAACCTG GACATTTTGT 1800

GGAACCCCTG AGTATGTTGC CCCTGAAGTC ATTCTGAGTA AAGGCCATGA CTTCAGCGTG 1860

GATTTTTGGT CCCTTGGGAT TCTTGTGTAT GAACTCCTCA CTGGCAGCCC ACCATTCTCT 1920

GGGGCTGATC AAATGATGAC ATACAATTTG ATCCTCAAAG GTATTGAAAA GCTGGATTTT 1980

CCTAAAGTAA TAACAAGGCG ACCTGAGGAT TTGATCCGCA GACTCTGCAG GCAAAACCCT 2040

ACAGAAAGAT TAGGCAATTT GAGGAATGGA ATAAATGACA TCAAGAAGCA CAGGTGGTTG 2100

AGTGGTTTTA ACTGGGATAG TCTGAAAGTG AGGAAATTAA CATCGCCTTT AAAAAGAGAG 2160

TTGTCTGGAC CAACTGATTA CAGCTACTTC GACAGCTATC CACCTGAAGT GGGAAGCCCT 2220

CCAGATGAAC TTTCAGGCTG GGACAAGGAC TTCTGA 2256

Domain Profile

S: 1     lkviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksd  60

         l+v++tlgvggfgrvelvkvk+ e+ afa+k++kkkh+vdtkqqeh++sek+ile+++s+

Q: 442   LEVVTTLGVGGFGRVELVKVKN-ENMAFAMKCIKKKHVVDTKQQEHIYSEKKILEQICSP  500

         689******************9.999**********************************

S: 61    fivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskn  120

         f+vklyrtfkd+kyvy+lleaclggelw++lrdrgsfd+ t+kf+v+cv+ea++ylh+ +

Q: 501   FVVKLYRTFKDNKYVYMLLEACLGGELWSLLRDRGSFDEFTTKFCVGCVTEAFDYLHQIG  560

         ************************************************************

S: 121   iiyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsv  180

         iiyrdlkpenl+ld+egy+klvdfgfakk++sg+ktwtfcgtpeyvape+il kghd+sv

Q: 561   IIYRDLKPENLILDAEGYIKLVDFGFAKKIGSGQKTWTFCGTPEYVAPEVILSKGHDFSV  620

         ************************************************************

S: 181   dywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnp  240

         d+w+lgilvyelltg+ppfsg+d+++tynlilkgi+kl++p+ it+++edli++lcr+np

Q: 621   DFWSLGILVYELLTGSPPFSGADQMMTYNLILKGIEKLDFPKVITRRPEDLIRRLCRQNP  680

         ************************************************************

S: 241   aerlgylkggikdikkhkwf  260

         +erlg+l++gi+dikkh+w+

Q: 681   TERLGNLRNGINDIKKHRWL  700

         *******************7

Domain Sequence
(FASTA)

LEVVTTLGVG GFGRVELVKV KNENMAFAMK CIKKKHVVDT KQQEHIYSEK KILEQICSPF 60

VVKLYRTFKD NKYVYMLLEA CLGGELWSLL RDRGSFDEFT TKFCVGCVTE AFDYLHQIGI 120

IYRDLKPENL ILDAEGYIKL VDFGFAKKIG SGQKTWTFCG TPEYVAPEVI LSKGHDFSVD 180

FWSLGILVYE LLTGSPPFSG ADQMMTYNLI LKGIEKLDFP KVITRRPEDL IRRLCRQNPT 240

ERLGNLRNGI NDIKKHRWL 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013