EKS-TAR-00460

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-TAR-00460

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tie	580.2	1.2E-174	351	619	269

Status

Unreviewed

Ensembl Protein

ENSTRUP00000047298

UniProt Accession

H2VDJ8;

Protein Name

Protein Synonyms/Alias

Gene Name

TIE1

Gene Synonyms/Alias

TIE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSTRUG00000018474	ENSTRUP00000047293	ENSTRUT00000047452
ENSTRUG00000018474	ENSTRUP00000047294	ENSTRUT00000047453
ENSTRUG00000018474	ENSTRUP00000047297	ENSTRUT00000047456
ENSTRUG00000018474	ENSTRUP00000047298	ENSTRUT00000047457
ENSTRUG00000018474	ENSTRUP00000047295	ENSTRUT00000047454
ENSTRUG00000018474	ENSTRUP00000047296	ENSTRUT00000047455

Organism

Takifugu rubripes

Functional Description

Protein Length

650

Protein Sequence
(FASTA)

TYRGDGPIIF TKILYTPENN EGSSSSIIVY SEKEPITLMN LEPSTRYRVR VQLSRPGEGG 60

EGVPGPETVM ETDCPDLKHF PKSLQLYGPP PHSEKLQEET TVLNVLSTKF HNLEYQQDYT 120

VVVRLINCGS QGPRSKPYQF RIHSQGVWPL LEWKSFENKY SPSSPRNVQA LPLSISAIQV 180

KWQPPDDPNG GIIKYTIEYQ PVGQGSPHPW VDTDDGVKTT KDVTALNGST LYQFRVKAFS 240

KVPGEWSDFV QATTQGDATK AVAGRPDGDS YQLLVAIVGS VTVTCVMILL ALLAVFFIRK 300

MMLNRRRTFT YQSGSGEETI LQFNSGTLTL TRRPKPTPEA LTYPILEWED IKFEDVIGEG 360

NFGQVIKAMV KKDGNKMSAA IKMLKEFASE NDHRDFAGEL EVLCKLGQHP NIINLIGACE 420

NRGYLYIAIE YAPYGNLLDF LRKSRVLETD PAFAKEHGTA STLTSQQLLQ FAVDVATGMH 480

YLSDKQFIHR DLAARNVLVG DNLVAKIADF GLSRGEEVYV KKTMGRLPVR WMAIESLNYS 540

VYTTKSDVWS FGVLLWEIVS LGGTPYCGMT CAELYEKLPQ GFRMEKPKNC DDEVYELMKL 600

CWRDRPYERP PFSQISVQLS RMQEARKAYV NMALFENFTY AGIDATAEEA 650

Nucleotide Sequence
(FASTA)

ACCTACAGAG GAGACGGTCC CATCATCTTC ACCAAAATTC TCTATACACC AGAGAATAAT 60

GAGGGTTCTT CGTCTTCTAT CATAGTTTAT AGTGAGAAAG AGCCCATCAC GCTGATGAAT 120

CTGGAGCCGT CAACGCGGTA CCGAGTCCGC GTGCAGCTGA GTCGTCCTGG TGAAGGTGGC 180

GAGGGGGTTC CGGGGCCAGA GACCGTCATG GAGACTGACT GTCCTGACTT GAAGCATTTT 240

CCTAAATCAT TGCAGCTGTA CGGGCCGCCG CCTCATAGTG AGAAACTGCA AGAGGAGACC 300

ACTGTGCTCA ATGTCCTTTC CACAAAGTTC CACAACCTGG AGTATCAGCA AGACTACACC 360

GTGGTGGTGC GCCTCATCAA CTGTGGCAGT CAGGGGCCGC GCTCCAAACC CTACCAGTTC 420

CGCATCCACA GCCAGGGGGT TTGGCCTTTG CTCGAGTGGA AGAGTTTTGA GAATAAATAC 480

AGTCCATCAT CCCCACGCAA TGTCCAGGCT CTGCCTCTGT CTATATCAGC CATCCAGGTG 540

AAATGGCAGC CTCCCGACGA CCCCAATGGA GGCATCATTA AATACACAAT CGAGTACCAG 600

CCGGTTGGCC AGGGGAGCCC TCACCCTTGG GTGGACACGG ATGATGGAGT CAAGACCACC 660

AAAGATGTGA CGGCACTCAA CGGCAGCACG CTGTATCAGT TCAGAGTCAA GGCTTTCTCC 720

AAAGTGCCGG GAGAGTGGAG CGACTTCGTT CAGGCGACGA CACAAGGAGA TGCCACTAAG 780

GCTGTAGCTG GGAGGCCTGA TGGGGACAGT TACCAGCTGC TGGTGGCAAT TGTGGGCTCA 840

GTAACTGTTA CCTGTGTTAT GATCCTGCTG GCACTGCTGG CGGTGTTCTT CATCCGCAAG 900

ATGATGCTCA ACCGTCGACG CACCTTCACC TACCAGTCTG GATCGGGTGA GGAGACGATT 960

CTGCAGTTTA ACTCAGGAAC ACTGACGCTG ACACGGAGGC CCAAGCCAAC ACCAGAGGCG 1020

CTCACCTATC CCATCTTGGA GTGGGAGGAC ATAAAGTTTG AAGATGTGAT CGGAGAGGGG 1080

AACTTTGGCC AGGTGATCAA AGCCATGGTC AAGAAGGATG GGAATAAAAT GAGCGCTGCC 1140

ATCAAAATGC TTAAAGAGTT TGCCTCAGAG AATGACCACC GGGACTTTGC GGGGGAGCTG 1200

GAGGTACTCT GCAAGTTGGG TCAACATCCC AACATCATCA ATCTAATCGG AGCCTGCGAG 1260

AACAGAGGTT ACCTGTACAT AGCCATCGAA TATGCTCCAT ACGGAAACCT CCTCGACTTC 1320

CTGAGGAAGA GTCGGGTGTT GGAGACGGAC CCTGCCTTTG CCAAGGAGCA TGGCACCGCT 1380

TCCACGCTGA CCTCTCAGCA GCTGCTGCAG TTTGCAGTTG ACGTGGCGAC AGGAATGCAT 1440

TATCTCAGCG ACAAACAGTT TATCCACAGG GATTTGGCAG CTAGGAATGT TCTCGTAGGT 1500

GATAACCTTG TGGCAAAAAT AGCAGACTTC GGCCTTTCCC GTGGTGAGGA AGTTTACGTA 1560

AAGAAGACAA TGGGAAGGCT GCCTGTTCGC TGGATGGCCA TTGAGTCCTT GAACTACAGC 1620

GTGTATACGA CCAAGAGTGA CGTGTGGTCT TTCGGTGTAC TCCTCTGGGA AATTGTAAGC 1680

TTGGGTGGTA CACCCTATTG CGGTATGACG TGTGCAGAGC TTTATGAAAA ACTACCACAA 1740

GGCTTCCGGA TGGAGAAGCC TAAAAACTGT GACGATGAGG TCTACGAGTT GATGAAACTG 1800

TGCTGGAGGG ACCGGCCGTA CGAGAGGCCC CCCTTCTCCC AGATCTCTGT CCAGCTCAGC 1860

AGGATGCAGG AGGCCAGGAA GGCTTATGTG AACATGGCTC TGTTTGAAAA CTTCACCTAT 1920

GCTGGGATAG ATGCCACAGC TGAGGAGGCC TGA 1953

Domain Profile

S: 1     ikfedligegnfgqvlkarikkdglkmdaaikrlkeyaskddhrdfagelevlcklghhp  60

         ikfed+igegnfgqv+ka++kkdg km aaik+lke+as++dhrdfagelevlcklg+hp

Q: 351   IKFEDVIGEGNFGQVIKAMVKKDGNKMSAAIKMLKEFASENDHRDFAGELEVLCKLGQHP  410

         89**********************************************************

S: 61    niinllgacenrgylylaieyapygnlldflrksrvletdpafaienstastlssrqllr  120

         niinl+gacenrgyly+aieyapygnlldflrksrvletdpafa+e++tastl+s+qll+

Q: 411   NIINLIGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAKEHGTASTLTSQQLLQ  470

         ************************************************************

S: 121   faadvargmdylsekqfihrdlaarnvlvgenlvakiadfglsrgeevyvkktmgrlpvr  180

         fa dva gm+yls+kqfihrdlaarnvlvg+nlvakiadfglsrgeevyvkktmgrlpvr

Q: 471   FAVDVATGMHYLSDKQFIHRDLAARNVLVGDNLVAKIADFGLSRGEEVYVKKTMGRLPVR  530

         ************************************************************

S: 181   wmaieslnysvyttksdvwsygvllweivslggtpycgmtcaelyeklpqgyrlekplnc  240

         wmaieslnysvyttksdvws+gvllweivslggtpycgmtcaelyeklpqg+r+ekp+nc

Q: 531   WMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGFRMEKPKNC  590

         ************************************************************

S: 241   ddevyelmrqcwrekpyerpsfaqillsl  269

         ddevyelm+ cwr++pyerp+f+qi ++l

Q: 591   DDEVYELMKLCWRDRPYERPPFSQISVQL  619

         **************************997

Domain Sequence
(FASTA)

IKFEDVIGEG NFGQVIKAMV KKDGNKMSAA IKMLKEFASE NDHRDFAGEL EVLCKLGQHP 60

NIINLIGACE NRGYLYIAIE YAPYGNLLDF LRKSRVLETD PAFAKEHGTA STLTSQQLLQ 120

FAVDVATGMH YLSDKQFIHR DLAARNVLVG DNLVAKIADF GLSRGEEVYV KKTMGRLPVR 180

WMAIESLNYS VYTTKSDVWS FGVLLWEIVS LGGTPYCGMT CAELYEKLPQ GFRMEKPKNC 240

DDEVYELMKL CWRDRPYERP PFSQISVQL 269

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR000742	; EG-like_dom.
IPR013032	; EGF-like_CS.
IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00181	; EGF; 3.
SM00060	; FN3; 3.
SM00409	; IG; 1.
SM00219	; TyrKc; 1.

Prosites

PS00022	; EGF_1; 3.
PS01186	; EGF_2; 3.
PS50026	; EGF_3; 3.
PS50853	; FN3; 3.
PS50835	; IG_LIKE; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013