EKS-SCP-00051

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SCP-00051

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	315.6	6.7E-95	658	938	281

Status

Reviewed

Ensembl Protein

SPAC167.01.1:pep

UniProt Accession

O94537;

Protein Name

Serine/threonine-protein kinase ppk4

Protein Synonyms/Alias

Gene Name

ppk4

Gene Synonyms/Alias

ppk4; SPAC167.01;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPAC167.01	SPAC167.01.1:pep	SPAC167.01.1

Organism

Schizosaccharomyces pombe

Functional Description

Protein Length

1072

Protein Sequence
(FASTA)

MKSLKGRLLF LRKFVFFSLL ILLFAHGASS SSSSFNYFDK RTNGKANNEL ALFSPTADSP 60

SSVDGVLELP SAENVFAESS LYNAFIVATV DGSLHSYDRI TGQELWSLFT NANPGLSYTK 120

DENSLLSSKF LSQSNFKSYN STHGEFYSDS TLNISYLSDD DTVWFVEPID GGILYAFNLQ 180

TGLVRLPHSI KDLVHASPIR LLNNNVFVGS KNTTLFTIDV SNGDIVSQYP SGHRYETHHS 240

VHNLGTKRDS VPSGADSDLS FKDPSGKKLS ESLDLLDDFN YQVTVSNKSF VDIARTEYFI 300

TIYSDSNVIL DLVYIDWTPT KNEIMYESFH SSSFDSKLAL SSYDSSLHIV DTHSKFIKQN 360

IPLMSPAATV FDIVTLPHNK KIDKSQTPAK FPTSVLLRQP IDTYLETMFP QIARNKTEHV 420

YINHIGNAWF AMSERHYPLV SLAPEASFLY YNGFYIPLNS IFGLHSLMAT PKPFFALPGL 480

PGYDIPSYVE SEGSTKTLPS IGKKPIPLLD PNPISSTPIS ITFWVIMFLS VSFTIVTFFS 540

ILRIRSSEVR PLKSQKNTVS INNKIDTSKR RRKGKRRKRV SDEHSASSNF NEIESQASFE 600

QNQTLDILSE NIVEIQDKST DPLQKSLDSS LKSHLPEATV IQNTDGSVTV NSLTVYPEVI 660

GYGSHGTIVY RGVYEDREVA VKRVLMEFYD LASREITLLQ QSDNHPNIVR YYCKQKSDQF 720

LYIVIELCKC NLSDLIEKPI AYDDLFKSID LVSLLYQIAF GVSHLHSLDL VHRDLKPQNI 780

LLVVNNSPNL SKTRVRALIS DFGLSKKLDF NQSSLRNTTF EAAGSYGWRS PEILSGSLSQ 840

QSKEIQVKTR EGRIRQASHA TDIFALGCIF YYTLTGGMHP FGSHYDCEGN ILKGNYCLVH 900

LQSLGECGVL AADLIEDMIA FEPSKRPTIE VVLNHPLFWD YAKKLDFLID VSDRFEVEER 960

DPPSPLLQML ENNSKSVIGE NWTTCLHSSL VDNLGKYRKY DGSKILDILR VLRNKRHHYQ 1020

DLPESVRRVL GDLPDGFTSY FVEKFPMLLL HCYHLVKDVL YEESQFKRYL EY 1072

Nucleotide Sequence
(FASTA)

ATGAAGAGTT TGAAAGGGCG TCTGTTATTT TTAAGAAAAT TCGTCTTTTT TTCGTTGTTG 60

ATTCTTCTAT TTGCTCATGG GGCTTCTTCT TCCTCTTCTT CGTTTAATTA TTTTGATAAA 120

AGAACCAATG GTAAAGCAAA CAATGAATTA GCTCTTTTTT CACCTACTGC TGATTCACCT 180

TCCTCTGTGG ATGGCGTATT AGAATTGCCA TCGGCAGAGA ATGTCTTCGC AGAATCTAGT 240

CTTTATAATG CCTTCATAGT TGCTACTGTT GATGGATCAT TGCATTCTTA TGATCGAATT 300

ACCGGCCAAG AACTTTGGTC GCTCTTCACA AACGCTAATC CAGGTCTCTC ATACACAAAA 360

GATGAAAATT CGCTTCTGTC AAGTAAATTT TTAAGTCAAT CAAATTTTAA ATCTTATAAT 420

AGTACTCATG GGGAATTTTA CAGTGATTCT ACTTTAAACA TCAGTTACTT ATCTGACGAC 480

GATACAGTTT GGTTTGTAGA ACCTATCGAT GGCGGAATAT TGTACGCTTT TAATTTACAA 540

ACTGGCTTAG TCAGACTTCC TCATTCAATA AAGGACCTCG TTCATGCATC ACCAATCCGT 600

CTGCTAAACA ACAATGTATT TGTTGGTAGC AAAAACACTA CGTTATTCAC TATTGATGTT 660

TCAAACGGGG ATATTGTCTC TCAATACCCT TCAGGCCATA GATATGAAAC ACATCACTCT 720

GTGCATAATT TAGGTACAAA AAGAGATTCT GTACCTTCTG GCGCAGACTC TGATTTATCA 780

TTTAAGGACC CTTCTGGTAA AAAATTGTCT GAAAGTTTGG ACTTGCTTGA TGATTTCAAT 840

TACCAGGTTA CTGTTTCAAA TAAATCGTTT GTTGATATTG CTAGAACGGA ATATTTCATA 900

ACAATATATT CTGATTCCAA TGTCATACTT GATTTGGTTT ACATCGATTG GACACCAACT 960

AAAAACGAAA TAATGTATGA ATCTTTTCAT TCATCATCTT TTGATTCGAA ACTTGCGCTT 1020

TCATCATATG ACAGTTCGTT GCACATTGTT GATACCCATT CCAAGTTCAT AAAACAGAAC 1080

ATCCCTTTGA TGTCTCCTGC TGCCACAGTG TTTGATATCG TAACTTTACC TCACAACAAG 1140

AAGATAGACA AATCTCAAAC ACCTGCGAAA TTTCCGACTT CTGTTCTGCT TCGACAACCG 1200

ATTGACACAT ACCTAGAAAC GATGTTTCCT CAAATTGCAA GAAACAAAAC TGAACACGTA 1260

TACATAAATC ATATAGGTAA TGCATGGTTT GCGATGTCGG AACGTCATTA TCCTTTGGTA 1320

TCACTTGCTC CGGAAGCTTC CTTCCTTTAT TACAATGGAT TTTATATTCC ACTGAATAGT 1380

ATTTTTGGAC TTCATTCCCT AATGGCAACC CCTAAGCCTT TTTTTGCTTT GCCAGGACTT 1440

CCTGGTTATG ATATTCCTTC TTACGTGGAA TCTGAAGGCT CAACAAAAAC ATTACCTTCA 1500

ATTGGAAAAA AACCTATTCC TTTACTAGAT CCAAATCCTA TTTCCTCTAC GCCTATTTCT 1560

ATCACATTTT GGGTTATAAT GTTCCTAAGT GTGTCTTTTA CAATTGTTAC CTTCTTTTCC 1620

ATTCTTAGGA TTCGCTCTTC TGAAGTCAGA CCGTTAAAAT CTCAGAAAAA TACGGTTTCT 1680

ATCAATAATA AAATTGATAC TTCAAAACGC CGGCGTAAAG GCAAACGAAG AAAGAGAGTT 1740

AGCGATGAGC ATTCGGCTTC TTCTAACTTC AACGAGATAG AAAGCCAGGC GTCTTTTGAA 1800

CAAAATCAAA CATTGGATAT CTTGAGTGAA AATATTGTTG AAATTCAAGA CAAATCAACT 1860

GATCCTTTAC AAAAAAGTCT CGATAGCAGC CTAAAAAGTC ATCTTCCTGA GGCAACTGTA 1920

ATCCAAAACA CTGATGGTTC AGTGACTGTA AACTCATTGA CTGTTTATCC TGAAGTAATT 1980

GGTTATGGTA GTCATGGTAC AATTGTTTAT CGTGGTGTTT ATGAAGATAG GGAGGTAGCT 2040

GTCAAGAGAG TTTTAATGGA GTTTTATGAC TTAGCATCAA GAGAAATAAC ACTTTTACAG 2100

CAGAGTGATA ATCATCCTAA TATCGTTCGT TATTATTGCA AACAAAAAAG TGACCAATTC 2160

CTTTACATTG TCATCGAATT ATGTAAATGC AACCTATCTG ATTTAATCGA AAAACCAATT 2220

GCTTATGATG ACCTATTCAA ATCGATTGAT CTAGTTTCAT TGCTATATCA AATAGCTTTT 2280

GGGGTTTCTC ATTTACATAG TTTGGATTTA GTTCATCGTG ATTTAAAGCC ACAAAATATT 2340

TTACTTGTTG TTAATAATTC GCCAAATCTT TCCAAAACTC GAGTCAGGGC TCTTATTTCC 2400

GATTTTGGAT TGAGCAAGAA GTTAGATTTT AATCAAAGCA GTCTTCGTAA TACCACTTTT 2460

GAGGCAGCCG GTTCTTATGG TTGGAGATCT CCGGAAATTT TAAGTGGTTC CCTGTCTCAA 2520

CAATCGAAAG AAATACAAGT GAAAACTCGT GAAGGTAGAA TCCGACAAGC TTCCCACGCT 2580

ACTGATATTT TTGCCCTCGG TTGTATTTTT TATTATACGT TAACTGGTGG GATGCACCCG 2640

TTTGGTTCCC ATTATGATTG TGAGGGCAAC ATTCTTAAAG GAAATTATTG TTTGGTACAT 2700

TTGCAATCAT TAGGAGAGTG TGGTGTGTTG GCCGCTGATT TGATTGAGGA TATGATTGCA 2760

TTTGAGCCAA GCAAGCGTCC TACAATCGAA GTGGTTTTGA ATCATCCGTT ATTTTGGGAC 2820

TATGCCAAAA AGCTTGATTT TTTAATTGAT GTTTCTGATC GATTCGAAGT TGAAGAAAGA 2880

GATCCACCTT CTCCGTTACT TCAAATGCTT GAAAACAATT CGAAATCTGT GATTGGAGAA 2940

AACTGGACAA CTTGTTTACA CTCGTCCCTA GTTGATAACC TTGGTAAATA TCGGAAGTAC 3000

GATGGTTCCA AAATTCTCGA CATTCTTCGG GTATTAAGAA ATAAGAGACA CCATTATCAA 3060

GACTTACCGG AGTCTGTGCG TCGTGTACTC GGCGATTTAC CAGACGGATT CACAAGTTAT 3120

TTTGTTGAAA AATTTCCAAT GCTTTTATTG CATTGTTATC ATTTGGTTAA AGATGTCCTG 3180

TACGAGGAAA GTCAATTTAA ACGTTATCTA GAGTATTGA 3219

Domain Profile

S: 5     dvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfctekd  64

         +v+G+G++Gt+v+rG +e+revavkr+l+ef+dla+re+ ll++sd+hpn++ry+c++k+

Q: 658   EVIGYGSHGTIVYRGVYEDREVAVKRVLMEFYDLASREITLLQQSDNHPNIVRYYCKQKS  717

         79**********************************************************

S: 65    rqfryialelcaaslqdyve....dkdlelqkelepisllkqiasGlahlhslkivhrdl  120

         +qf yi +elc+ +l d++e        +l k+++++sll qia G++hlhsl++vhrdl

Q: 718   DQFLYIVIELCKCNLSDLIEkpiaY--DDLFKSIDLVSLLYQIAFGVSHLHSLDLVHRDL  775

         ********************54332..345689***************************

S: 121   kpqnilislpd....akgklrvlisdfGlckkldvGkssfsr.rsgvsGteGwiapelle  175

         kpqnil+ +++    +k ++r+lisdfGl kkld+ +ss+++ + + +G+ Gw++pe+l+

Q: 776   KPQNILLVVNNspnlSKTRVRALISDFGLSKKLDFNQSSLRNtTFEAAGSYGWRSPEILS  835

         ******999987888999**********************9967899*************

S: 176   e...............ltkerltsavdifslGcvfyyvlskGkhpfGdslkrqanilsge  220

                            +++++a dif+lGc+fyy l++G hpfG ++  + nil+g+

Q: 836   GslsqqskeiqvktreGRIRQASHATDIFALGCIFYYTLTGGMHPFGSHYDCEGNILKGN  895

         999********9988755678899************************************

S: 221   lsldklkeekdeeviaedliskmidkdplkrpsakkvlkhplf  263

         ++l +l+++ +  v+a dli++mi+ +p krp+ + vl+hplf

Q: 896   YCLVHLQSLGECGVLAADLIEDMIAFEPSKRPTIEVVLNHPLF  938

         ******************************************9

Domain Sequence
(FASTA)

EVIGYGSHGT IVYRGVYEDR EVAVKRVLME FYDLASREIT LLQQSDNHPN IVRYYCKQKS 60

DQFLYIVIEL CKCNLSDLIE KPIAYDDLFK SIDLVSLLYQ IAFGVSHLHS LDLVHRDLKP 120

QNILLVVNNS PNLSKTRVRA LISDFGLSKK LDFNQSSLRN TTFEAAGSYG WRSPEILSGS 180

LSQQSKEIQV KTREGRIRQA SHATDIFALG CIFYYTLTGG MHPFGSHYDC EGNILKGNYC 240

LVHLQSLGEC GVLAADLIED MIAFEPSKRP TIEVVLNHPL F 281

Keyword

ATP-binding; Complete proteome; Endoplasmic reticulum; Kinase; Membrane; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005789	; C:endoplasmic reticulum membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004521	; F:endoribonuclease activity
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030968	; P:endoplasmic reticulum unfolded protein response
GO:0006397	; P:mRNA processing
GO:0043066	; P:negative regulation of apoptotic process

KEGG

spo:SPAC167.01

;

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR018391	; PQQ_beta_propeller_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00564	; PQQ; 3.
SM00580	; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013