EPS-MUM-00157

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MUM-00157

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PTP-Other/TULA-2	N/A	N/A	N/A	N/A	N/A

Status

Reviewed

Ensembl Protein

ENSMUSP00000043865

UniProt Accession

Q8BGG7; Q3U8Z2; Q8BMW9;

Protein Name

Ubiquitin-associated and SH3 domain-containing protein B

Protein Synonyms/Alias

Cbl-interacting protein p70; Suppressor of T-cell receptor signaling 1; STS-1; T-cell ubiquitin ligand 2; TULA-2; Tyrosine-protein phosphatase STS1/TULA2;

Gene Name

Ubash3b

Gene Synonyms/Alias

Ubash3b; Sts1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMUSG00000032020	ENSMUSP00000114176	ENSMUST00000136530
ENSMUSG00000032020	ENSMUSP00000134923	ENSMUST00000129906
ENSMUSG00000032020	ENSMUSP00000116038	ENSMUST00000151485
ENSMUSG00000032020	ENSMUSP00000043865	ENSMUST00000044155

Organism

Mus musculus

Functional Description

Interferes with CBL-mediated down-regulation anddegradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Protein Length

638

Protein Sequence
(FASTA)

MAAREELYSK VTPRRDRLQR PGTVKHGSAL DVLLSMGFPR ARAQKALAST GGRSVQAACD 60

WLFSHVGDPF LDDPLPREYV LYLRPTGPLA QKLSDFWQQS KQICGKNKAH NIFPHITLCQ 120

FFMCEDSKVD ALGEALQTTV SRWKCKFSAP LPLELYTSSN FIGLFVKEDS AEVLKKFAAD 180

FAAEAASKTE VHVEPHKKQL HVTLAYHFQA SHLPTLEKLA QNIDVKLGCD WVATIFSRDI 240

RFANHETLQV IYPYSPQNDD ELELVPGDFI FMSPMEQTST SEGWIYGTSL TTGCSGLLPE 300

NYITKADECS TWIFHGSYSI LNTVSSSSLA FGDGALERRQ YEDQGLGETT PLTIICQPMQ 360

PLRVNSQPGP QKRCLFVCRH GERMDVVFGK YWLSQCFDAK GRYIRTNLNM PHSLPQRSGG 420

FRDYEKDAPI TVFGCMQARL VGEALLESNT VIDHVYCSPS LRCVQTAHNI LKGLQQDNHL 480

KIRVEPGLFE WTKWVAGSTL PAWIPPSELA AANLSVDTTY RPHIPVSKLA ISESYDTYIN 540

RSFQVTKEII SECKSKGNNI LIVAHASSLE ACTCQLQGLS PQNSKDFVQM VRKIPYLGFC 600

SCEELGETGI WQLTDPPILP LTHGPTGGFN WRETLLQE 638

Nucleotide Sequence
(FASTA)

ATGGCCGCGC GCGAGGAGCT GTACAGCAAA GTCACCCCGC GCAGGGACCG CCTGCAGCGC 60

CCGGGCACAG TCAAGCATGG GTCGGCGCTG GACGTGCTCC TGTCCATGGG CTTTCCCCGC 120

GCCCGCGCAC AAAAAGCTCT GGCATCCACG GGAGGAAGAA GCGTTCAGGC AGCATGTGAC 180

TGGTTGTTCT CCCATGTGGG TGACCCCTTC CTGGATGACC CCCTGCCTCG GGAGTATGTC 240

CTCTACCTCC GCCCGACAGG GCCATTAGCC CAGAAGCTCT CTGACTTCTG GCAGCAGTCC 300

AAGCAGATCT GCGGGAAGAA CAAGGCCCAC AACATCTTCC CCCACATCAC TCTCTGCCAG 360

TTCTTCATGT GCGAGGACAG CAAGGTGGAT GCTCTGGGGG AAGCCCTGCA GACTACTGTC 420

AGTCGATGGA AATGTAAGTT CTCAGCCCCA CTGCCCCTGG AGCTGTACAC CTCCTCCAAC 480

TTCATCGGGC TCTTCGTGAA GGAAGACAGC GCTGAAGTCC TCAAGAAGTT CGCGGCTGAC 540

TTTGCTGCAG AGGCTGCATC CAAAACAGAA GTGCACGTGG AGCCTCATAA GAAGCAGCTG 600

CATGTGACGC TGGCCTACCA CTTCCAAGCC AGCCACCTAC CCACCCTAGA GAAGCTTGCC 660

CAGAACATTG ACGTCAAGCT AGGATGCGAC TGGGTGGCCA CCATATTCTC TCGGGATATC 720

CGGTTTGCTA ACCATGAGAC GTTACAGGTG ATCTATCCCT ATTCACCTCA GAATGATGAC 780

GAGCTGGAGC TGGTCCCAGG GGACTTCATC TTCATGTCTC CCATGGAACA GACCAGCACC 840

AGTGAGGGCT GGATTTATGG CACCTCGCTG ACCACTGGCT GCTCTGGGCT GCTTCCTGAG 900

AACTACATCA CCAAGGCTGA TGAGTGTAGC ACCTGGATCT TCCATGGTTC CTACTCCATC 960

CTAAATACCG TATCATCCAG CTCACTCGCG TTTGGCGATG GAGCGTTAGA GAGGCGGCAG 1020

TATGAAGATC AAGGACTTGG GGAGACAACA CCCCTCACTA TCATCTGCCA GCCCATGCAG 1080

CCCCTGAGAG TCAACAGCCA GCCTGGACCC CAGAAGCGAT GCCTCTTTGT ATGTCGGCAT 1140

GGGGAGAGGA TGGACGTTGT ATTTGGGAAG TACTGGCTGT CCCAATGCTT TGATGCCAAA 1200

GGCCGCTACA TACGCACCAA CCTGAACATG CCTCACAGTT TACCTCAGAG GAGCGGCGGT 1260

TTCCGGGATT ACGAGAAAGA TGCTCCAATC ACTGTGTTTG GGTGTATGCA AGCAAGACTA 1320

GTGGGTGAAG CCTTGTTAGA AAGTAATACT GTTATTGATC ACGTGTATTG CTCACCATCC 1380

CTCCGCTGCG TTCAGACTGC ACATAATATT TTGAAAGGTT TACAACAAGA CAATCACTTG 1440

AAGATTCGAG TGGAGCCGGG CTTATTTGAA TGGACAAAGT GGGTTGCTGG GAGCACATTA 1500

CCGGCATGGA TACCTCCATC AGAGTTAGCT GCAGCCAACC TGAGTGTTGA TACAACCTAC 1560

AGACCTCACA TTCCAGTCAG CAAATTGGCG ATTTCGGAAT CCTATGACAC CTACATCAAT 1620

AGGAGTTTCC AGGTGACGAA AGAGATAATA AGTGAATGCA AAAGTAAAGG AAATAACATT 1680

CTGATTGTGG CCCACGCATC TTCCCTCGAA GCGTGTACCT GTCAGCTCCA AGGTCTATCC 1740

CCGCAGAACT CAAAGGACTT CGTACAAATG GTCCGGAAGA TCCCATACCT AGGCTTCTGT 1800

TCCTGCGAAG AATTGGGAGA AACTGGAATA TGGCAACTGA CAGACCCGCC CATCCTTCCC 1860

CTTACCCATG GCCCCACTGG GGGCTTCAAC TGGAGAGAGA CCCTCCTGCA AGAATAA 1917

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome; SH3 domain.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0004725	; F:protein tyrosine phosphatase activity
GO:0035335	; P:peptidyl-tyrosine dephosphorylation

KEGG

mmu:72828

;

InterPros

IPR013078	; His_Pase_superF_clade-1.
IPR001452	; SH3_domain.
IPR009060	; UBA-like.
IPR000449	; UBA/transl_elong_EF1B_N.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00300	; His_Phos_1; 1.
PF00627	; UBA; 1.

SMARTs

SM00326	; SH3; 1.
SM00165	; UBA; 1.

Prosites

PS50002	; SH3; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013