EKS-ART-00577

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ART-00577

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	142.4	3.2E-41	548	704	157

Status

Unreviewed

Ensembl Protein

AT2G17520.1

UniProt Accession

Q0WPT1;

Protein Name

Protein Synonyms/Alias

Endoribonuclease/protein kinase IRE1;

Gene Name

At2g17520

Gene Synonyms/Alias

At2g17520;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
AT2G17520	AT2G17520.1	AT2G17520.1

Organism

Arabidopsis thaliana

Functional Description

Protein Length

841

Protein Sequence
(FASTA)

MPPRCPFLRH LFFLLLLLSP WIMSPCGGAA DDVTYPIVPS SPGRRSILQI RREPPTEPNT 60

KLVVDRDGKV FLKQQPKETP YWSFSTGSPM HSLYQAPANN NTENATEITR PHIIVEYLNN 120

SKAATTVDGY HNWTVQEFFR QKPLVTDDGV TLGSETTSAY LVDGRSGRLI HVYKSTGDTK 180

ITNALVKPAS TEDFVNEPLL IRRTDSKLEH FSKTTGKLVW NLTVSHFRAA LLCDPVFNSG 240

YDLGPKLQTG IYMPLLCGSQ IDVRGPEIVI RVLHDQPMNV KMLPSPSLNH FESENSIMPF 300

GKARESRKLQ EQHKQKYTYL FGQWSPVKLL APLVLLGVVV SVFIKKFSSR GSDVSLKAGP 360

SKKKKNRKSA KDTNRQSVPR GQDQFELIEG GQMLLGFNNF QSGATDGRKI GKLFLSSKEI 420

AKGSNGTVVF EGIYEGRPVA VKRLVRSHHE VAFKEIQNLI ASDQHTNIIR WYGVEYDQDF 480

VYLSLERCTC SLDDLIKSYL EFSMTKVLEN NDSTEGVAAY KIQLDSLEGV IKGNNFWKVG 540

GHPSPLMLKL MRDIVCGIVH LHELGIVHRD LKPQNVLISK DMTLSAKLSD MGISKRMSRD 600

MSSLGHLATG SGSSGWQAPE QLLQGRQTRA VDMFSLGCVI FYTITGCKHP FGDDLERDVN 660

IVKNKVDLFL VEHVPEASDL ISRLLNPDPD LRPSATEVLL HPMFWNSEMR LSFLRDASDR 720

VELENREADS EILKAMESTA PVAIGGKWDE KLEPVFITNI GRYRRYKYDS IRDLLRVIRN 780

KLNHHRELPP EIQELVGTVP EGFDEYFAVR FPKLLIEVYR VISLHCREEE VFRKYFKCDI 840

I 841

Nucleotide Sequence
(FASTA)

ATGCCGCCGA GATGTCCTTT CCTCCGCCAT CTTTTCTTCT TACTACTATT ACTCTCACCA 60

TGGATCATGT CTCCTTGCGG CGGCGCTGCC GACGATGTGA CGTATCCGAT CGTTCCATCT 120

AGTCCCGGCC GCAGATCAAT TTTGCAGATT CGTCGTGAAC CACCAACAGA GCCAAATACG 180

AAACTTGTTG TTGATCGTGA TGGGAAGGTG TTTTTAAAGC AGCAACCGAA AGAAACACCA 240

TACTGGTCCT TTTCAACAGG ATCACCAATG CACTCGTTAT ATCAGGCTCC TGCTAATAAC 300

AACACAGAAA ATGCTACTGA GATAACTCGT CCTCACATAA TTGTTGAATA TCTGAACAAC 360

TCAAAGGCGG CTACTACTGT CGATGGCTAT CATAATTGGA CAGTTCAGGA GTTTTTTAGG 420

CAGAAGCCAC TTGTAACAGA TGATGGTGTG ACTCTTGGAT CAGAAACAAC TAGTGCCTAT 480

TTGGTTGATG GTAGATCAGG GAGGCTGATT CATGTTTACA AATCAACTGG AGATACTAAG 540

ATTACTAATG CTCTCGTGAA GCCCGCTAGC ACTGAAGATT TTGTGAATGA ACCTCTTCTT 600

ATCAGGCGAA CAGATTCCAA ACTTGAGCAT TTTAGTAAAA CCACTGGGAA GCTTGTCTGG 660

AATTTGACGG TTTCTCACTT CAGAGCTGCT TTACTATGTG ATCCTGTTTT CAATTCTGGC 720

TATGACCTCG GTCCTAAACT TCAAACTGGA ATTTATATGC CATTGTTATG TGGATCACAA 780

ATTGACGTTC GTGGCCCAGA AATTGTTATC AGGGTGCTCC ATGATCAGCC AATGAATGTG 840

AAAATGCTAC CCTCCCCTTC CCTAAATCAC TTCGAGAGCG AAAACAGCAT CATGCCTTTT 900

GGAAAAGCCA GAGAGTCAAG AAAGTTACAA GAGCAACATA AGCAGAAATA TACATATTTG 960

TTTGGACAAT GGTCACCAGT AAAGTTATTG GCCCCTTTAG TGCTTCTAGG TGTTGTTGTC 1020

TCTGTTTTCA TTAAAAAGTT TTCGTCGAGG GGCAGTGATG TTAGTTTGAA AGCTGGACCT 1080

TCCAAAAAGA AGAAGAACCG TAAATCCGCG AAGGATACAA ATAGGCAGTC AGTTCCTCGT 1140

GGCCAGGATC AGTTCGAGCT CATTGAAGGA GGTCAAATGT TACTAGGCTT CAATAACTTT 1200

CAAAGTGGTG CAACTGATGG GAGAAAGATC GGTAAGTTGT TTCTGTCAAG TAAAGAAATT 1260

GCAAAGGGAA GTAACGGAAC TGTGGTGTTT GAGGGTATTT ACGAAGGCCG GCCTGTAGCT 1320

GTAAAACGCC TTGTTCGATC TCATCATGAG GTTGCTTTCA AAGAGATTCA AAACCTCATT 1380

GCATCAGACC AACACACAAA CATCATTCGG TGGTATGGTG TGGAGTATGA TCAAGATTTT 1440

GTATACCTTT CTCTAGAGCG TTGCACCTGC AGTTTAGATG ATCTAATCAA ATCCTATTTA 1500

GAGTTTTCTA TGACAAAAGT ATTGGAAAAC AACGATTCTA CTGAAGGAGT GGCTGCTTAT 1560

AAGATCCAAC TTGATTCTTT GGAGGGAGTT ATCAAAGGAA ACAACTTTTG GAAAGTGGGG 1620

GGTCACCCGT CACCTCTCAT GCTTAAACTA ATGAGGGATA TAGTTTGTGG AATCGTCCAC 1680

TTACACGAAT TGGGAATAGT TCATCGGGAC TTGAAGCCAC AAAATGTGTT AATTAGTAAA 1740

GATATGACTT TGAGTGCAAA ACTGTCCGAT ATGGGCATTA GCAAGCGTAT GTCCAGAGAT 1800

ATGTCATCAT TGGGTCACCT TGCCACAGGT TCTGGCAGTT CGGGCTGGCA AGCACCAGAG 1860

CAGCTTCTAC AAGGTCGTCA AACTCGTGCA GTCGATATGT TTAGTTTAGG TTGTGTCATC 1920

TTTTACACTA TAACCGGTTG TAAGCATCCC TTTGGTGATG ATCTTGAACG AGATGTCAAT 1980

ATTGTGAAGA ACAAAGTCGA CCTATTTCTA GTAGAACACG TTCCAGAAGC TTCAGACCTC 2040

ATATCCCGTT TGTTAAACCC AGACCCTGAT TTACGTCCTA GCGCAACTGA AGTGCTACTC 2100

CATCCTATGT TTTGGAACTC AGAGATGAGA CTGTCTTTCC TTCGTGATGC TAGTGACCGA 2160

GTTGAGCTTG AAAATAGAGA AGCTGATTCT GAAATCTTGA AAGCAATGGA GAGTACAGCT 2220

CCAGTGGCTA TAGGAGGGAA ATGGGATGAA AAGCTAGAAC CTGTTTTCAT CACAAACATC 2280

GGGCGCTACA GGCGTTACAA ATACGATAGC ATCCGTGACT TGTTACGAGT CATCAGGAAC 2340

AAACTGAATC ATCATCGAGA ACTTCCTCCG GAAATTCAGG AACTTGTCGG AACAGTTCCA 2400

GAAGGATTCG ACGAGTACTT TGCTGTACGG TTTCCGAAAT TGTTGATTGA AGTCTATAGA 2460

GTCATCTCTC TGCATTGTAG GGAAGAAGAA GTATTCAGAA AGTACTTCAA ATGCGACATC 2520

ATCTAA 2526

Domain Profile

S: 97    isllkqiasGlahlhslkivhrdlkpqnilislpdakgklrvlisdfGlckkldvGkssf  156

          +l++ i+ G+ hlh l ivhrdlkpqn+lis      +l + +sd+G+ k+++   ss+

Q: 548   LKLMRDIVCGIVHLHELGIVHRDLKPQNVLISKD---MTLSAKLSDMGISKRMSRDMSSL  604

         5799***************************975...567889*****************

S: 157   srrsgvsGteGwiapelleeltkerltsavdifslGcvfyyvlskGkhpfGdslkrqani  216

          + +  sG++Gw ape l    + r+t+avd+fslGcv +y +++ khpfGd+l+r+ ni

Q: 605   GHLATGSGSSGWQAPEQLL---QGRQTRAVDMFSLGCVIFYTITGCKHPFGDDLERDVNI  661

         ****************988...899***********************************

S: 217   lsgelsldklkeekdeeviaedliskmidkdplkrpsakkvlkhplf  263

         +++++ l  +++  +    a+dlis++++ dp  rpsa++vl hp+f

Q: 662   VKNKVDLFLVEHVPE----ASDLISRLLNPDPDLRPSATEVLLHPMF  704

         ***998876665554....67************************99

Domain Sequence
(FASTA)

LKLMRDIVCG IVHLHELGIV HRDLKPQNVL ISKDMTLSAK LSDMGISKRM SRDMSSLGHL 60

ATGSGSSGWQ APEQLLQGRQ TRAVDMFSLG CVIFYTITGC KHPFGDDLER DVNIVKNKVD 120

LFLVEHVPEA SDLISRLLNP DPDLRPSATE VLLHPMF 157

Keyword

Kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Arabidopsis lyrata"; ?>Brachypodium distachyon"; ?>Brassica rapa"; ?>Cyanidioschyzon merolae"; ?>Glycine max"; ?>Musa acuminata"; ?>Oryza brachyantha"; ?>Oryza glaberrima"; ?>Oryza indica"; ?>Oryza sativa"; ?>Populus trichocarpa"; ?>Selaginella moellendorffii"; ?>Setaria italica"; ?>Solanum lycopersicum"; ?>Solanum tuberosum"; ?>Sorghum bicolor"; ?>Zea mays"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006397	; P:mRNA processing

KEGG

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00580

; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013