EPS-ART-00016
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-ART-00016
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
PPM/PP2C347.21.2E-103104387284
StatusReviewed
Ensembl ProteinAT3G11410.1
UniProt AccessionP49598;
Protein NameProtein phosphatase 2C 37
Protein Synonyms/Alias AtPP2C37; Protein ABA-HYPERSENSITIVE GERMINATION 3; Protein phosphatase 2C A; PP2CA;
Gene NamePP2CA
Gene Synonyms/Alias PP2CA; AHG3; At3g11410; F24K9.8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
AT3G11410AT3G11410.1AT3G11410.1
OrganismArabidopsis thaliana
Functional DescriptionMajor negative regulator of abscisic acid (ABA)responses during seed germination and cold acclimation. Confers insensitivity to ABA. Modulates negatively the AKT2/3 activity, which mediates K(+) transport and membrane polarization during stress situations, probably by dephosphorylation. Prevent stomata closure by inactivating the S-type anion efflux channel SLAC1 and its activator SRK2E.
Protein Length399
Protein Sequence
(FASTA)
MAGICCGVVG ETEPAAPVDS TSRASLRRRL DLLPSIKIVA DSAVAPPLEN CRKRQKRETV 60
VLSTLPGNLD LDSNVRSENK KARSAVTNSN SVTEAESFFS DVPKIGTTSV CGRRRDMEDA 120
VSIHPSFLQR NSENHHFYGV FDGHGCSHVA EKCRERLHDI VKKEVEVMAS DEWTETMVKS 180
FQKMDKEVSQ RECNLVVNGA TRSMKNSCRC ELQSPQCDAV GSTAVVSVVT PEKIIVSNCG 240
DSRAVLCRNG VAIPLSVDHK PDRPDELIRI QQAGGRVIYW DGARVLGVLA MSRAIGDNYL 300
KPYVIPDPEV TVTDRTDEDE CLILASDGLW DVVPNETACG VARMCLRGAG AGDDSDAAHN 360
ACSDAALLLT KLALARQSSD NVSVVVVDLR KRRNNQASS 399
Nucleotide Sequence
(FASTA)
ATGGCTGGGA TTTGTTGCGG TGTTGTTGGA GAGACTGAAC CGGCGGCACC GGTTGATTCA 60
ACTTCTCGAG CTTCTCTTAG ACGGAGGTTA GATCTACTTC CGTCGATCAA AATTGTTGCT 120
GACTCCGCCG TTGCTCCTCC GCTTGAAAAC TGCCGTAAAC GGCAGAAGCG TGAGACAGTA 180
GTGCTCTCGA CGTTACCGGG AAATCTAGAT CTGGATTCGA ATGTGAGGAG TGAGAATAAG 240
AAGGCTAGAT CAGCGGTTAC GAATTCAAAT TCTGTTACGG AAGCAGAGAG TTTCTTTTCC 300
GATGTACCTA AGATCGGTAC GACGTCGGTT TGTGGTAGAA GACGAGACAT GGAAGACGCT 360
GTCTCGATTC ATCCTTCGTT TCTTCAACGG AACTCTGAGA ATCATCATTT CTACGGTGTC 420
TTTGACGGCC ATGGCTGCTC TCATGTTGCG GAGAAGTGCA GAGAACGGTT GCATGATATA 480
GTGAAGAAGG AAGTTGAAGT TATGGCTTCC GACGAGTGGA CAGAGACGAT GGTTAAGAGT 540
TTTCAAAAAA TGGATAAAGA AGTTAGCCAA CGAGAGTGTA ACTTAGTTGT TAATGGTGCT 600
ACTCGGAGTA TGAAAAATTC TTGTAGATGT GAATTGCAGT CTCCTCAGTG TGACGCCGTC 660
GGATCCACCG CTGTTGTATC GGTTGTCACG CCGGAGAAGA TCATTGTTTC TAATTGCGGT 720
GATTCACGGG CTGTGCTTTG TCGTAACGGT GTAGCCATTC CTCTCTCCGT AGATCACAAG 780
CCGGATCGAC CCGATGAATT GATTCGGATC CAACAAGCTG GTGGGCGAGT TATATATTGG 840
GATGGAGCTA GGGTTCTTGG AGTTCTTGCC ATGTCTAGAG CAATTGGTGA TAATTACTTG 900
AAACCGTATG TGATTCCGGA TCCGGAGGTA ACAGTGACGG ATCGAACTGA TGAGGATGAG 960
TGTTTGATCT TGGCGAGTGA TGGACTATGG GATGTTGTAC CAAACGAGAC GGCGTGTGGC 1020
GTGGCTCGCA TGTGCCTTCG AGGTGCTGGT GCGGGTGACG ACTCAGATGC GGCGCACAAT 1080
GCGTGCTCCG ATGCGGCGTT GCTCTTAACA AAGTTGGCTC TAGCAAGACA GAGCTCCGAT 1140
AACGTGAGCG TCGTTGTGGT TGACTTGAGG AAGAGGAGGA ATAATCAAGC GTCGTCTTAA 1200
Domain Profile
S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61
         ++g++sv+grr++medav+++p+fl+++++++  +f+gv+DGhg+s+va++c+e+lh+i+
Q: 104   KIGTTSVCGRRRDMEDAVSIHPSFLQRNSENH--HFYGVFDGHGCSHVAEKCRERLHDIV  161
         789***********************999876..8*************************
S: 62    aeelesseseerkvkkalakaFlstdeel.....................kvleeksldi  100
         ++e+e     ++++++++ k+F+++d+e+                     ++l+++  ++
Q: 162   KKEVE--VMASDEWTETMVKSFQKMDKEVsqrecnlvvngatrsmknscrCELQSP--QC  217
         ***99..7899*************************************77777777..**
S: 101   dksGstavvalikdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsv  160
         d++Gstavv++++++k++v+n+GdSravLcrng a++ls+dHkp+r+dEl Ri++agg+v
Q: 218   DAVGSTAVVSVVTPEKIIVSNCGDSRAVLCRNGVAIPLSVDHKPDRPDELIRIQQAGGRV  277
         ************************************************************
S: 161   ilkdgaRvlGvLavsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsnee  220
         i++dgaRvlGvLa+sRa+Gd+ylkpyv+p+Pevt++++t ede+liLasDGlwdvv+ne+
Q: 278   IYWDGARVLGVLAMSRAIGDNYLKPYVIPDPEVTVTDRTDEDECLILASDGLWDVVPNET  337
         ************************************************************
S: 221   avslvrdvle..........kkeaeqeaakkLvklalargskdnvsaivv  260
         a+ ++r++l+           ++a+++aa  L+klalar+s+dnvs++vv
Q: 338   ACGVARMCLRgagagddsdaAHNACSDAALLLTKLALARQSSDNVSVVVV  387
         *********************************************99997
Domain Sequence
(FASTA)
KIGTTSVCGR RRDMEDAVSI HPSFLQRNSE NHHFYGVFDG HGCSHVAEKC RERLHDIVKK 60
EVEVMASDEW TETMVKSFQK MDKEVSQREC NLVVNGATRS MKNSCRCELQ SPQCDAVGST 120
AVVSVVTPEK IIVSNCGDSR AVLCRNGVAI PLSVDHKPDR PDELIRIQQA GGRVIYWDGA 180
RVLGVLAMSR AIGDNYLKPY VIPDPEVTVT DRTDEDECLI LASDGLWDVV PNETACGVAR 240
MCLRGAGAGD DSDAAHNACS DAALLLTKLA LARQSSDNVS VVVV 284
KeywordAbscisic acid signaling pathway; Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Arabidopsis lyrata"; ?>Brassica rapa"; ?>Glycine max"; ?>Populus trichocarpa"; ?>Solanum lycopersicum"; ?>Solanum tuberosum"; ?>
EPS-ARL-00019
EPS-BRR-00021
EPS-GLM-00036
EPS-POT-00025
EPS-SOL-00022
EPS-SOT-00021
Gene Ontology
GO:0046872; F:metal ion binding
GO:0004722; F:protein serine/threonine phosphatase activity
GO:0009738; P:abscisic acid mediated signaling pathway
GO:0009788; P:negative regulation of abscisic acid mediated signaling pathway
GO:0010360; P:negative regulation of anion channel activity
GO:0006470; P:protein dephosphorylation
GO:0010119; P:regulation of stomatal movement
GO:0009409; P:response to cold
GO:0009414; P:response to water deprivation
KEGG
ath:AT3G11410;
InterPros
IPR001932; PP2C-like.
IPR000222; PP2C_Mn2_Asp60_BS.
IPR015655; Protein_Pase_2C.
Pfam
PF00481; PP2C; 1.
SMARTs
SM00331; PP2C_SIG; 1.
SM00332; PP2Cc; 1.
Prosites
PS01032; PP2C; 1.
Prints
Created Date20-Feb-2013