EKS-ART-00597
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ART-00597
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK418.03.0E-1254287284
StatusReviewed
Ensembl ProteinAT3G48750.1
UniProt AccessionP24100; Q29Q50; Q8RX68; Q9M307;
Protein NameCyclin-dependent kinase A-1
Protein Synonyms/Alias CDKA; Cell division control protein 2 homolog A;
Gene NameCDKA-1
Gene Synonyms/Alias CDKA-1; CDC2, CDC2A; At3g48750; T21J18.20;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
AT3G48750AT3G48750.1AT3G48750.1
OrganismArabidopsis thaliana
Functional DescriptionInvolved in the control of the cell cycle. Essential forboth G1/S and G2/M (mitosis) phase transitions. Functions in cell morphogenesis as well as cell proliferation. Required for cell division (entry into mitosis) of the generative cell in male gametogenesis.
Protein Length294
Protein Sequence
(FASTA)
MDQYEKVEKI GEGTYGVVYK ARDKVTNETI ALKKIRLEQE DEGVPSTAIR EISLLKEMQH 60
SNIVKLQDVV HSEKRLYLVF EYLDLDLKKH MDSTPDFSKD LHMIKTYLYQ ILRGIAYCHS 120
HRVLHRDLKP QNLLIDRRTN SLKLADFGLA RAFGIPVRTF THEVVTLWYR APEILLGSHH 180
YSTPVDIWSV GCIFAEMISQ KPLFPGDSEI DQLFKIFRIM GTPYEDTWRG VTSLPDYKSA 240
FPKWKPTDLE TFVPNLDPDG VDLLSKMLLM DPTKRINARA ALEHEYFKDL GGMP 294
Nucleotide Sequence
(FASTA)
ATGGATCAGT ACGAGAAAGT TGAGAAGATT GGTGAAGGAA CTTACGGTGT GGTTTATAAG 60
GCACGTGACA AAGTGACTAA TGAGACAATT GCTTTGAAGA AGATCAGGCT AGAGCAGGAG 120
GATGAAGGTG TTCCTAGCAC AGCAATCAGA GAAATCTCCC TCTTGAAAGA AATGCAGCAC 180
AGCAACATTG TCAAATTGCA GGATGTGGTG CACAGCGAGA AACGTTTGTA TCTGGTTTTT 240
GAGTATCTTG ACTTGGATCT CAAAAAGCAC ATGGATTCTA CTCCTGATTT CTCCAAGGAT 300
CTACATATGA TCAAAACATA TCTTTACCAG ATTCTCCGTG GAATTGCGTA TTGCCACTCT 360
CATAGGGTTC TCCATCGTGA TCTGAAGCCA CAGAATTTGT TGATTGATCG CCGCACAAAC 420
TCACTGAAGC TTGCTGATTT TGGACTGGCC AGAGCATTCG GTATCCCTGT CAGGACATTT 480
ACTCATGAGG TTGTTACTCT CTGGTACCGA GCACCAGAGA TACTCCTAGG ATCTCATCAT 540
TACTCTACAC CTGTTGATAT TTGGTCTGTG GGGTGCATAT TTGCTGAGAT GATCAGCCAA 600
AAGCCCTTAT TTCCTGGAGA CTCCGAGATT GATCAACTCT TCAAGATTTT CAGAATCATG 660
GGAACTCCGT ACGAGGATAC ATGGCGTGGG GTAACTTCTC TACCGGATTA TAAATCTGCT 720
TTCCCTAAAT GGAAACCAAC GGACCTAGAA ACTTTTGTCC CCAATCTAGA TCCCGATGGA 780
GTCGATCTCC TTTCTAAAAT GCTGTTAATG GATCCGACCA AAAGAATCAA CGCAAGAGCC 840
GCCCTGGAGC ATGAATACTT CAAGGATCTT GGAGGCATGC CTTAG 885
Domain Profile
S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60
         yek+ekigeGtyg+vyka+dk t+e++AlKkirle+e+egvp+ta+rEisllke++h+ni
Q: 4     YEKVEKIGEGTYGVVYKARDKVTNETIALKKIRLEQEDEGVPSTAIREISLLKEMQHSNI  63
         99**********************************************************
S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120
         vkL++vv+ ++k+lyLvfe+l+ dLkk +++++  + +l+++k++l+q+l+g+ay+Hs++
Q: 64    VKLQDVVH-SEKRLYLVFEYLDLDLKKHMDSTPDFSKDLHMIKTYLYQILRGIAYCHSHR  122
         ********.99***********************999***********************
S: 121   ilHRDlKpqNlLiske.gklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179
         +lHRDlKpqNlLi+++ ++lklaDfGlaraf+ p++t+t+evvTlwYraPe+Llg+++Ys
Q: 123   VLHRDLKPQNLLIDRRtNSLKLADFGLARAFGIPVRTFTHEVVTLWYRAPEILLGSHHYS  182
         *************987699*****************************************
S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239
         t vDiWsvgci+ae++++kplf+g+seidql++if+++gtp e++w +v++lp+yk++fp
Q: 183   TPVDIWSVGCIFAEMISQKPLFPGDSEIDQLFKIFRIMGTPYEDTWRGVTSLPDYKSAFP  242
         ************************************************************
S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284
         k+k+++l++ v++l+ +++dll+k+l +dp+kRi+a++al+h+yf
Q: 243   KWKPTDLETFVPNLDPDGVDLLSKMLLMDPTKRINARAALEHEYF  287
         ********************************************9
Domain Sequence
(FASTA)
YEKVEKIGEG TYGVVYKARD KVTNETIALK KIRLEQEDEG VPSTAIREIS LLKEMQHSNI 60
VKLQDVVHSE KRLYLVFEYL DLDLKKHMDS TPDFSKDLHM IKTYLYQILR GIAYCHSHRV 120
LHRDLKPQNL LIDRRTNSLK LADFGLARAF GIPVRTFTHE VVTLWYRAPE ILLGSHHYST 180
PVDIWSVGCI FAEMISQKPL FPGDSEIDQL FKIFRIMGTP YEDTWRGVTS LPDYKSAFPK 240
WKPTDLETFV PNLDPDGVDL LSKMLLMDPT KRINARAALE HEYF 284
KeywordATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Kinase; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Arabidopsis lyrata"; ?>Brachypodium distachyon"; ?>Brassica rapa"; ?>Chlamydomonas reinhardtii"; ?>Cyanidioschyzon merolae"; ?>Glycine max"; ?>Hordeum vulgare"; ?>Musa acuminata"; ?>Oryza brachyantha"; ?>Oryza glaberrima"; ?>Oryza indica"; ?>Oryza sativa"; ?>Physcomitrella patens"; ?>Populus trichocarpa"; ?>Selaginella moellendorffii"; ?>Setaria italica"; ?>Solanum lycopersicum"; ?>Solanum tuberosum"; ?>Sorghum bicolor"; ?>Vitis vinifera"; ?>Zea mays"; ?>
EKS-ARL-00582
EKS-BRD-00640
EKS-BRR-01305
EKS-CHR-00284
EKS-CYM-00041
EKS-GLM-00108
EKS-HOV-00866
EKS-MUA-00781
EKS-ORB-00957
EKS-ORG-00948
EKS-ORI-01201
EKS-ORS-00777
EKS-PHP-00449
EKS-POT-01023
EKS-SEM-00639
EKS-SEI-00659
EKS-SOL-00592
EKS-SOT-00622
EKS-SOB-01023
EKS-VIV-00676
EKS-ZEM-00803
Gene Ontology
GO:0010005; C:cortical microtubule, transverse to long axis
GO:0005829; C:cytosol
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0009574; C:preprophase band
GO:0005524; F:ATP binding
GO:0004693; F:cyclin-dependent protein kinase activity
GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0000910; P:cytokinesis
GO:0042023; P:DNA endoreduplication
GO:0009793; P:embryo development ending in seed dormancy
GO:0007067; P:mitosis
GO:0009555; P:pollen development
GO:0008284; P:positive regulation of cell proliferation
GO:0040020; P:regulation of meiosis
GO:0009409; P:response to cold
KEGG
ath:AT3G48750;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013