EKS-ART-00008
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ART-00008
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE11291.01.7E-86333587255
StatusReviewed
Ensembl ProteinAT4G08500.1
UniProt AccessionQ39008; O81470; Q39020; Q8W4N5;
Protein NameMitogen-activated protein kinase kinase kinase 1
Protein Synonyms/Alias ARAKIN; AtMEKK1; MAP kinase kinase kinase 1;
Gene NameMEKK1
Gene Synonyms/Alias MEKK1; At4g08500; T15F16.5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
AT4G08500AT4G08500.1AT4G08500.1
OrganismArabidopsis thaliana
Functional DescriptionInvolved in the innate immune MAP kinase signalingcascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in the cold and salinity stress-mediated MAP kinase signaling cascade (MEKK1, MEK1/MKK2 and MPK4/MPK6). Activates downstream MKK2, MKK4 and MKK5.
Protein Length608
Protein Sequence
(FASTA)
MDRILARMKK STGRRGGDKN ITPVRRLERR DAARNINYDA ASCSSSSAED LSVSTSSLMT 60
RSLEFPEPTS FRIGGGVGEM DRIYRSLGVS GPDDLAISFD AWEACKKRSS SDVVNRFKSF 120
DLDKVRDQDL SEEGPSGVVV GSDSMNHKVQ GQDLSEAGPS GGIVTELSEI GNLITPVDRL 180
VADGVVENRR VMERTPTIVK SKGYLVPNNV VAVGVGVGGG IKGLRPPVLK PPPAMKRPPI 240
DHRGSSWDFL THFAPSETVK RPSSSSSSSE DGCDEEEGKE EEAEAEEMGA RFIQLGDTAD 300
ETCSFTTNEG DSSSTVSNTS PIYPDGGAII TSWQKGQLLG RGSFGSVYEG ISGDGDFFAV 360
KEVSLLDQGS QAQECIQQLE GEIKLLSQLQ HQNIVRYRGT AKDGSNLYIF LELVTQGSLL 420
KLYQRYQLRD SVVSLYTRQI LDGLKYLHDK GFIHRDIKCA NILVDANGAV KLADFGLAKV 480
SKFNDIKSCK GTPFWMAPEV INRKDSDGYG SPADIWSLGC TVLEMCTGQI PYSDLEPVQA 540
LFRIGRGTLP EVPDTLSLDA RLFILKCLKV NPEERPTAAE LLNHPFVRRP LPSVGSGGSG 600
SASPLLRR 608
Nucleotide Sequence
(FASTA)
ATGGACAGAA TTCTAGCTCG TATGAAGAAA TCAACTGGAC GAAGAGGAGG AGATAAGAAT 60
ATTACTCCGG TACGGCGGTT AGAGCGTCGC GATGCGGCGA GGAATATCAA TTACGACGCA 120
GCTTCATGTT CTAGTTCGTC AGCTGAAGAT CTTTCCGTTT CGACTTCTTC GTTGATGACT 180
CGCTCTTTGG AGTTTCCGGA GCCTACTAGT TTCCGAATCG GTGGTGGTGT TGGAGAGATG 240
GATCGGATTT ATCGGTCTCT TGGTGTTTCT GGTCCTGATG ATTTGGCTAT TTCTTTTGAT 300
GCTTGGGAAG CTTGTAAGAA ACGTTCTTCT TCAGATGTTG TTAATAGGTT TAAGTCTTTT 360
GATCTTGATA AGGTTCGTGA TCAGGATTTG AGTGAAGAAG GTCCTAGTGG TGTTGTTGTT 420
GGTTCTGATT CAATGAATCA TAAGGTTCAG GGTCAGGATT TGAGTGAAGC AGGTCCTAGT 480
GGTGGAATTG TTACTGAGTT GAGTGAGATT GGGAATTTAA TCACTCCTGT GGATAGGTTA 540
GTAGCTGATG GTGTGGTAGA GAATAGGCGT GTTATGGAAA GAACACCAAC TATTGTGAAG 600
TCGAAAGGGT ATCTTGTACC AAATAATGTA GTGGCTGTTG GTGTTGGTGT TGGTGGTGGT 660
ATTAAGGGGC TAAGACCACC AGTACTTAAG CCTCCTCCGG CTATGAAACG ACCCCCTATT 720
GATCATCGGG GATCGTCTTG GGATTTCCTG ACGCATTTCG CTCCAAGTGA AACAGTTAAG 780
CGGCCGAGTT CCTCTTCTTC TTCTTCCGAG GATGGATGCG ATGAAGAGGA AGGCAAGGAA 840
GAGGAAGCGG AAGCGGAAGA GATGGGAGCT AGGTTTATCC AGTTGGGGGA TACGGCTGAC 900
GAGACGTGCT CATTCACTAC AAATGAGGGT GACTCCTCAA GCACAGTATC CAATACTTCG 960
CCTATCTATC CAGATGGAGG AGCTATCATA ACGTCTTGGC AAAAGGGTCA ACTTTTGGGA 1020
CGAGGATCAT TTGGTTCTGT GTATGAAGGC ATTTCTGGAG ATGGGGACTT CTTTGCTGTC 1080
AAGGAAGTTT CACTTCTTGA TCAGGGAAGT CAGGCACAAG AATGCATACA ACAACTTGAG 1140
GGGGAGATTA AACTACTTAG TCAGCTTCAG CATCAGAATA TTGTGAGATA TCGTGGCACA 1200
GCCAAGGATG GGTCAAACTT GTACATTTTT CTTGAGCTTG TAACCCAAGG GTCCCTTCTA 1260
AAACTCTACC AAAGATACCA GCTTCGGGAC TCTGTAGTCT CCTTGTACAC TAGACAGATT 1320
CTTGACGGTT TGAAATATCT CCACGATAAA GGTTTTATTC ACAGGGACAT CAAATGTGCA 1380
AATATATTGG TGGACGCTAA TGGCGCCGTC AAACTTGCAG ATTTTGGATT GGCAAAGGTT 1440
TCAAAGTTTA ACGACATTAA GTCCTGCAAG GGAACTCCAT TTTGGATGGC TCCAGAGGTT 1500
ATTAACCGAA AGGATAGTGA TGGCTATGGA AGTCCAGCTG ATATATGGAG CCTCGGGTGC 1560
ACTGTGCTGG AAATGTGTAC TGGTCAGATC CCCTACTCTG ATCTCGAACC CGTTCAAGCC 1620
CTGTTTAGGA TCGGAAGGGG TACTCTTCCG GAAGTACCTG ATACGTTATC ACTAGATGCT 1680
CGGCTTTTCA TACTTAAGTG TCTTAAAGTG AACCCGGAAG AGCGGCCAAC TGCAGCTGAA 1740
CTGCTGAACC ATCCATTTGT GAGAAGACCC TTACCATCCG TGGGTTCAGG AGGCTCGGGA 1800
TCAGCATCTC CCCTTCTCCG TAGATGA 1827
Domain Profile
S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60
         wqk++++g+Gsfgsvy++++   g   avKev++  + +++++ +++l+ Eikll++l+H
Q: 333   WQKGQLLGRGSFGSVYEGIS-GDGDFFAVKEVSLLDQGSQAQECIQQLEGEIKLLSQLQH  391
         99*****************9.7799*********999999999*****************
S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120
         +niv+y G++++ ++l+iflE v +Gsl +l ++y +l++sv++ yt+qil gl+yLH+k
Q: 392   QNIVRYRGTAKDGSNLYIFLELVTQGSLLKLYQRY-QLRDSVVSLYTRQILDGLKYLHDK  450
         *******************************9976.8***********************
S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikk.k  179
         + +HRDiK aNil+d++g vkl+DFG +k  +      ++ +s++Gt+++maPEvi++ +
Q: 451   GFIHRDIKCANILVDANGAVKLADFGLAKVSKF-----NDIKSCKGTPFWMAPEVINRkD  505
         **************************9975443.....34689**************978
S: 180   ekgygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipeklseegkdf  239
         ++gyg+ aDiWslgc+v+em tg+ P+++l e+++++f++g  +  Pe+p++ls +++ f
Q: 506   SDGYGSPADIWSLGCTVLEMCTGQIPYSDL-EPVQALFRIGRGT-LPEVPDTLSLDARLF  563
         89****************************.************9.***************
S: 240   lekcleldpkkrpsaeeLLkhefl  263
         + kcl+++p++rp+a+eLL+h+f+
Q: 564   ILKCLKVNPEERPTAAELLNHPFV  587
         **********************96
Domain Sequence
(FASTA)
WQKGQLLGRG SFGSVYEGIS GDGDFFAVKE VSLLDQGSQA QECIQQLEGE IKLLSQLQHQ 60
NIVRYRGTAK DGSNLYIFLE LVTQGSLLKL YQRYQLRDSV VSLYTRQILD GLKYLHDKGF 120
IHRDIKCANI LVDANGAVKL ADFGLAKVSK FNDIKSCKGT PFWMAPEVIN RKDSDGYGSP 180
ADIWSLGCTV LEMCTGQIPY SDLEPVQALF RIGRGTLPEV PDTLSLDARL FILKCLKVNP 240
EERPTAAELL NHPFV 255
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Stress response; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Arabidopsis lyrata"; ?>Brachypodium distachyon"; ?>Brassica rapa"; ?>Glycine max"; ?>Hordeum vulgare"; ?>Musa acuminata"; ?>Oryza brachyantha"; ?>Oryza glaberrima"; ?>Oryza indica"; ?>Oryza sativa"; ?>Physcomitrella patens"; ?>Populus trichocarpa"; ?>Setaria italica"; ?>Solanum lycopersicum"; ?>Solanum tuberosum"; ?>Sorghum bicolor"; ?>Vitis vinifera"; ?>Zea mays"; ?>
EKS-ARL-00007
EKS-BRD-00010
EKS-BRR-00005
EKS-GLM-00383
EKS-HOV-00006
EKS-MUA-00010
EKS-ORB-00010
EKS-ORG-00013
EKS-ORI-00010
EKS-ORS-00012
EKS-PHP-00009
EKS-POT-00017
EKS-SEI-00009
EKS-SOL-00012
EKS-SOT-00010
EKS-SOB-00008
EKS-VIV-00009
EKS-ZEM-00011
Gene Ontology
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0003677; F:DNA binding
GO:0004709; F:MAP kinase kinase kinase activity
GO:0046777; P:protein autophosphorylation
GO:0009409; P:response to cold
GO:0009651; P:response to salt stress
GO:0009611; P:response to wounding
KEGG
ath:AT4G08500;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013