EKS-ART-00626
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ART-00626
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK124.96.5E-3621172152
StatusReviewed
Ensembl ProteinAT4G28980.1
UniProt AccessionO80345;
Protein NameCyclin-dependent kinase F-1
Protein Synonyms/Alias CDKF; CDK-activating kinase 1-At; CAK1-At;
Gene NameCDKF-1
Gene Synonyms/Alias CDKF-1; CAK1; At4g28980; F19B15.10;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
AT4G28980AT4G28980.1AT4G28980.1
AT4G28980AT4G28980.2AT4G28980.2
OrganismArabidopsis thaliana
Functional DescriptionCDK-activating kinase that modulates CDKD-2 and CDKD-3activities by phosphorylation of the T-loop. Activates CDKD-2 C- terminal domain (CTD) kinase activity. Activates CDKA-1 probably by phosphorylation. Posseses a CDK kinase activity independently of association with cyclin CYCH1-1. Phosphorylates the CTD of the large subunit of RNA polymerase II.
Protein Length479
Protein Sequence
(FASTA)
MDKQPATSWS IHTRPEIIAK YEIFERVGSG AYADVYRARR LSDGLIVALK EIFDYQSAFR 60
EIDALTILNG SPNVVVMHEY FWREEENAVL VLEFLRSDLA AVIRDGKRKK KVEGGDGFSV 120
GEIKRWMIQI LTGVDACHRN LIVHRDLKPG NMLISDDGVL KLADFGQARI LMEHDIVASD 180
ENQQAYKLED KDGETSEPPE VIPDYENSPR QGSDGQEREA MSKDEYFRQV EELKAKQVVR 240
DDTDKDSNVH DGDISCLATC TVSEMDDDLG RNSFSYDADE AVDDTQGLMT SCVGTRWFRP 300
PELLYGSTMY GLEVDLWSLG CVFAELLSLE PLFPGISDID QISRVTNVLG NLNEEVWPGC 360
VDLPDYKSIS FAKVESPLGI EGCLPNHSGD VISLLKKLIC YDPASRATTM EMLNDKYLSE 420
EPLPVPVSEL YVPPTMSGPD EDSPRKWNDY REMDSDSDFD GFGPMNVKPT SSGFTIEFP 479
Nucleotide Sequence
(FASTA)
ATGGATAAAC AACCGGCGAC CAGTTGGAGT ATCCATACCC GGCCGGAGAT AATCGCCAAG 60
TACGAGATCT TCGAGCGAGT CGGATCCGGA GCTTACGCCG ACGTTTACAG AGCTCGCCGT 120
CTCTCCGACG GTCTAATCGT CGCGCTCAAG GAGATTTTCG ATTACCAATC TGCGTTCCGG 180
GAGATTGACG CGCTCACCAT CCTCAATGGA TCTCCTAATG TAGTTGTTAT GCACGAATAC 240
TTCTGGCGTG AGGAAGAGAA CGCTGTGCTT GTGCTTGAGT TTCTTAGGTC GGATCTCGCT 300
GCGGTGATCC GAGATGGTAA GAGGAAGAAG AAGGTAGAAG GAGGGGATGG ATTCTCGGTT 360
GGGGAGATTA AGAGATGGAT GATTCAGATT TTAACCGGTG TTGATGCTTG TCATCGGAAT 420
TTGATTGTAC ATAGAGATTT GAAGCCTGGG AATATGTTGA TTTCTGATGA TGGAGTTCTT 480
AAGCTTGCTG ATTTTGGTCA GGCTAGGATA CTCATGGAGC ATGATATTGT AGCTTCAGAT 540
GAAAACCAAC AAGCTTACAA ACTGGAAGAC AAAGATGGAG AAACCAGCGA ACCACCAGAA 600
GTTATTCCTG ATTATGAGAA CTCACCTAGG CAAGGGTCTG ATGGTCAGGA ACGGGAAGCG 660
ATGAGTAAAG ACGAGTACTT CCGACAGGTG GAAGAGCTCA AGGCTAAACA GGTTGTTAGA 720
GATGATACTG ATAAGGACTC GAATGTGCAT GATGGAGACA TATCTTGCCT TGCAACGTGC 780
ACTGTTAGTG AAATGGATGA TGATCTCGGT AGGAACTCGT TTTCTTACGA TGCTGACGAA 840
GCAGTGGATG ATACACAGGG TTTGATGACA TCTTGTGTGG GAACCCGATG GTTTAGGCCA 900
CCAGAACTGC TCTATGGATC TACGATGTAT GGGTTAGAGG TCGATCTATG GTCGCTTGGT 960
TGTGTGTTTG CAGAACTCTT GTCTCTTGAG CCTTTGTTCC CAGGAATTTC AGATATTGAT 1020
CAGATCAGCA GAGTGACCAA TGTGCTGGGA AATTTAAATG AAGAGGTCTG GCCTGGTTGT 1080
GTTGATCTTC CAGACTACAA GTCAATCTCA TTTGCTAAAG TAGAATCTCC TCTTGGTATT 1140
GAAGGATGCC TTCCCAACCA TTCAGGGGAT GTGATATCGC TGCTCAAGAA GCTTATCTGT 1200
TATGATCCAG CTAGTAGAGC TACTACTATG GAGATGCTGA ATGACAAATA TTTAAGTGAA 1260
GAGCCTCTTC CAGTTCCAGT TTCAGAGCTC TATGTGCCTC CGACAATGAG TGGACCAGAT 1320
GAGGATTCTC CGAGAAAGTG GAATGATTAC AGAGAAATGG ATTCAGATTC AGATTTTGAT 1380
GGCTTTGGAC CCATGAATGT AAAGCCTACC AGTAGTGGAT TTACAATAGA ATTCCCCTGA 1440
Domain Profile
S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkel.khkn  59
         ye +e++g G+y+ vy+a++ ++g +vAlK+i  +       ++a rEi  l  l   +n
Q: 21    YEIFERVGSGAYADVYRARRLSDGLIVALKEI-FDY------QSAFREIDALTILnGSPN  73
         8899****************************.333......48***********6689*
S: 60    ivkLlevvakdkkklyLvfefleqdLkkllkkkkkk.......klsleevkslllqlleg  112
         +v ++e + +++++ +Lv+efl++dL+ ++++ k+k       ++s  e+k++++q+l+g
Q: 74    VVVMHEYFWREEENAVLVLEFLRSDLAAVIRDGKRKkkveggdGFSVGEIKRWMIQILTG  133
         *********9********************9988888999**9*****************
S: 113   laylHsnkilHRDlKpqNlLiskegklklaDfGlarafs  151
         ++ +H+n i+HRDlKp N+Lis++g+lklaDfG ar   
Q: 134   VDACHRNLIVHRDLKPGNMLISDDGVLKLADFGQARILM  172
         ************************************874
Domain Sequence
(FASTA)
YEIFERVGSG AYADVYRARR LSDGLIVALK EIFDYQSAFR EIDALTILNG SPNVVVMHEY 60
FWREEENAVL VLEFLRSDLA AVIRDGKRKK KVEGGDGFSV GEIKRWMIQI LTGVDACHRN 120
LIVHRDLKPG NMLISDDGVL KLADFGQARI LM 152
KeywordATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Arabidopsis lyrata"; ?>Brachypodium distachyon"; ?>Brassica rapa"; ?>Glycine max"; ?>Hordeum vulgare"; ?>Musa acuminata"; ?>Oryza brachyantha"; ?>Oryza glaberrima"; ?>Oryza indica"; ?>Oryza sativa"; ?>Physcomitrella patens"; ?>Populus trichocarpa"; ?>Selaginella moellendorffii"; ?>Setaria italica"; ?>Solanum lycopersicum"; ?>Solanum tuberosum"; ?>Sorghum bicolor"; ?>Vitis vinifera"; ?>Zea mays"; ?>
EKS-ARL-00597
EKS-BRD-00668
EKS-BRR-01351
EKS-GLM-00175
EKS-HOV-00885
EKS-MUA-00826
EKS-ORB-00980
EKS-ORG-00972
EKS-ORI-01231
EKS-ORS-00807
EKS-PHP-00471
EKS-POT-01058
EKS-SEM-00658
EKS-SEI-00688
EKS-SOL-00615
EKS-SOT-00651
EKS-SOB-01052
EKS-VIV-00699
EKS-ZEM-00859
Gene Ontology
GO:0005829; C:cytosol
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0019912; F:cyclin-dependent protein kinase activating kinase activity
GO:0004693; F:cyclin-dependent protein kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0051301; P:cell division
GO:0010078; P:maintenance of root meristem identity
GO:0000079; P:regulation of cyclin-dependent protein kinase activity
KEGG
ath:AT4G28980;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013