EKS-ART-00452
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ART-00452
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PDK1299.35.1E-8944311268
StatusReviewed
Ensembl ProteinAT5G04510.2
UniProt AccessionQ9XF67; Q9LZ74;
Protein Name3-phosphoinositide-dependent protein kinase 1
Protein Synonyms/Alias AtPDK1;
Gene NamePDPK1
Gene Synonyms/Alias PDPK1; PDK1; At5g04510; T32M21.110;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
AT5G04510AT5G04510.1AT5G04510.1
AT5G04510AT5G04510.2AT5G04510.2
OrganismArabidopsis thaliana
Functional DescriptionMay couple lipid signals to the activation-loopphosphorylation of several protein kinases of the so-called AGC kinase family. Interacts via its pleckstrin homology domain with phosphatidic acid, PtdIns3P and PtdIns(3,4)P2 and to a lesser extent with PtdIns(4,5)P2 and PtdIns4P. May play a general role in signaling processes controlling the pathogen/stress response, polar auxin transport and development. Transphosphorylates the AGC protein kinases OXI1/AGC2-1, PK1/S6K1, PK19/S6K2 and PID resulting in their activation.
Protein Length408
Protein Sequence
(FASTA)
MLAMEKEFDS KLVLQGNSSN GANVSRSKSF SFKAPQENFT SHDFEFGKIY GVGSYSKVVR 60
AKKKETGTVY ALKIMDKKFI TKENKTAYVK LERIVLDQLE HPGIIKLYFT FQDTSSLYMA 120
LESCEGGELF DQITRKGRLS EDEARFYTAE VVDALEYIHS MGLIHRDIKP ENLLLTSDGH 180
IKIADFGSVK PMQDSQITVL PNAASDDKAC TFVGTAAYVP PEVLNSSPAT FGNDLWALGC 240
TLYQMLSGTS PFKDASEWLI FQRIIARDIK FPNHFSEAAR DLIDRLLDTE PSRRPGAGSE 300
GYVALKRHPF FNGVDWKNLR SQTPPKLAPD PASQTASPER DDTHGSPWNL THIGDSLATQ 360
NEGHSAPPTS SESSGSITRL ASIDSFDSRW WGHLSFICFL GSNLVQSS 408
Nucleotide Sequence
(FASTA)
ATGTTGGCAA TGGAGAAAGA ATTTGATTCA AAGCTTGTTC TTCAAGGGAA CTCATCCAAC 60
GGTGCTAATG TTTCTAGAAG CAAAAGCTTC TCCTTTAAAG CTCCTCAAGA AAATTTCACC 120
AGCCATGATT TCGAATTTGG CAAGATCTAT GGTGTTGGTT CTTACTCTAA GGTTGTTAGG 180
GCAAAGAAGA AGGAAACTGG AACTGTGTAT GCTTTAAAGA TTATGGACAA AAAGTTTATC 240
ACCAAGGAGA ATAAAACTGC TTATGTGAAA TTGGAAAGGA TTGTTCTTGA TCAACTTGAA 300
CATCCTGGGA TCATTAAACT TTACTTCACG TTTCAAGACA CATCCTCACT ATATATGGCA 360
CTTGAATCTT GTGAGGGTGG CGAGCTTTTC GACCAAATAA CCAGAAAAGG TCGGCTATCG 420
GAGGATGAAG CTCGGTTCTA CACTGCAGAA GTTGTGGATG CTCTTGAGTA TATACATAGT 480
ATGGGACTGA TTCATCGAGA TATTAAGCCG GAGAATCTGT TGCTGACTTC AGATGGACAC 540
ATTAAGATTG CGGATTTTGG AAGTGTAAAG CCGATGCAGG ATAGCCAGAT CACAGTTCTA 600
CCTAATGCAG CTTCTGACGA TAAGGCGTGC ACTTTTGTCG GGACTGCTGC ATATGTTCCT 660
CCAGAAGTTC TCAACTCCTC TCCCGCAACT TTCGGGAATG ATCTTTGGGC TCTCGGCTGC 720
ACTCTCTATC AGATGCTTTC GGGGACTTCC CCATTTAAAG ATGCAAGTGA ATGGCTGATT 780
TTCCAAAGAA TTATAGCCAG AGATATAAAG TTCCCAAATC ATTTTTCAGA AGCAGCAAGA 840
GACCTCATCG ACCGGTTGCT GGATACCGAG CCAAGCAGAA GGCCAGGTGC TGGCTCAGAA 900
GGTTATGTTG CTCTTAAGAG ACATCCTTTC TTTAATGGAG TTGACTGGAA GAATCTAAGG 960
TCCCAGACTC CTCCAAAACT AGCTCCAGAT CCTGCGTCTC AGACAGCATC TCCCGAGAGG 1020
GATGACACAC ATGGTTCTCC ATGGAACCTG ACACATATTG GAGATTCTTT AGCCACACAG 1080
AACGAGGGGC ACAGTGCTCC TCCTACATCT TCTGAATCAT CGGGTTCCAT AACTCGACTT 1140
GCTTCAATAG ACTCTTTTGA TTCAAGATGG TGGGGGCATT TAAGCTTCAT TTGTTTTCTG 1200
GGCAGCAACC TTGTTCAAAG CTCCTAA 1227
Domain Profile
S: 1     fkfekelgeGsystvvlarekeskkeyaikvlekryiikekkvkyvtrekevlaklnehp  60
         f f+k+ g Gsys vv+a++ke+   ya+k+++k++i ke+k  yv+ e+ vl++l ehp
Q: 44    FEFGKIYGVGSYSKVVRAKKKETGTVYALKIMDKKFITKENKTAYVKLERIVLDQL-EHP  102
         7899****************************************************.9**
S: 61    givkLyatfqDeeslyfvleyakkGdllellkkvgsfdeactryyaaellsaleflhkkg  120
         gi+kLy+tfqD +sly+ le  + G+l + +++ g + e  +r+y+ae+++ale++h+ g
Q: 103   GIIKLYFTFQDTSSLYMALESCEGGELFDQITRKGRLSEDEARFYTAEVVDALEYIHSMG  162
         ************************************************************
S: 121   iihrDlkpeniLldkdgkilitDfGsakvlepklkedskkeeeesarsksfvGtaeyvsP  180
         +ihrD+kpen+Ll +dg+i+i+DfGs k +++++  +  ++  +  ++ +fvGta yv P
Q: 163   LIHRDIKPENLLLTSDGHIKIADFGSVKPMQDSQI-TVLPNAASDDKACTFVGTAAYVPP  221
         ******************************55544.4677788888999***********
S: 181   elLtdsevskssDlWalgcilyqllaGkpPfraeneylifkkilkleyafpegfpekakd  240
         e+L++s ++   DlWalgc+lyq+l+G+ Pf++++e+lif++i++ + +fp++f+e a+d
Q: 222   EVLNSSPATFGNDLWALGCTLYQMLSGTSPFKDASEWLIFQRIIARDIKFPNHFSEAARD  281
         ************************************************************
S: 241   lveklLvkdakerltlee.....ikahkff  265
         l+++lL +++++r ++       +k+h+ff
Q: 282   LIDRLLDTEPSRRPGAGSegyvaLKRHPFF  311
         *************9987778999******9
Domain Sequence
(FASTA)
FEFGKIYGVG SYSKVVRAKK KETGTVYALK IMDKKFITKE NKTAYVKLER IVLDQLEHPG 60
IIKLYFTFQD TSSLYMALES CEGGELFDQI TRKGRLSEDE ARFYTAEVVD ALEYIHSMGL 120
IHRDIKPENL LLTSDGHIKI ADFGSVKPMQ DSQITVLPNA ASDDKACTFV GTAAYVPPEV 180
LNSSPATFGN DLWALGCTLY QMLSGTSPFK DASEWLIFQR IIARDIKFPN HFSEAARDLI 240
DRLLDTEPSR RPGAGSEGYV ALKRHPFF 268
KeywordAlternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Chlamydomonas reinhardtii"; ?>Hordeum vulgare"; ?>Physcomitrella patens"; ?>
EKS-CHR-00181
EKS-HOV-00497
EKS-PHP-00352
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016020; C:membrane
GO:0004676; F:3-phosphoinositide-dependent protein kinase activity
GO:0005524; F:ATP binding
GO:0070300; F:phosphatidic acid binding
GO:0035091; F:phosphatidylinositol binding
GO:0045860; P:positive regulation of protein kinase activity
GO:0046777; P:protein autophosphorylation
KEGG
ath:AT5G04510;
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50003; PH_DOMAIN; FALSE_NEG.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013