EPS-ART-00055

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ART-00055

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	179.9	1.3E-52	291	574	284

Status

Reviewed

Ensembl Protein

AT5G19280.1

UniProt Accession

P46014;

Protein Name

Protein phosphatase 2C 70

Protein Synonyms/Alias

AtPP2C70; Kinase-associated protein phosphatase;

Gene Name

KAPP

Gene Synonyms/Alias

KAPP; At5g19280; F7K24.30, T24G5.3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
AT5G19280	AT5G19280.2	AT5G19280.2
AT5G19280	AT5G19280.1	AT5G19280.1

Organism

Arabidopsis thaliana

Functional Description

Dephosphorylates the Ser/Thr receptor-like kinase RLK5.May function as a signaling component in a pathway involving RLK5.

Protein Length

581

Protein Sequence
(FASTA)

MAMIGMNIIG LFMVLMLLLI SLIILFACKP WRYFSRFRSS SRFSSTFKVG DLQRPLISDD 60

GNLIQGQTSE VTREYDLEGA CYQNDGLLHS SLTEGRFYKQ RLPSSSPHFS QGESFVLEVI 120

SEPSDNALVG QTLKLPAEKG SLAEVQTYDW QNNRNENLQY NLEKDRLINL SPRLVEDQRS 180

WLFLEVIAGP AIGLQHAVNS TSSSKLPVKL GRVSPSDLAL KDSEVSGKHA QITWNSTKFK 240

WELVDMGSLN GTLVNSHSIS HPDLGSRKWG NPVELASDDI ITLGTTTKVY VRISSQNEFQ 300

IPFKIGVASD PMAMRRGGRK LPMEDVCHYK WPLPGANKFG LFCVCDGHGG SGAAQSAIKI 360

IPEVLANILS DSLRKEKVLS KRDASDVLRD MFAKTEARLE EHQYEGCTAT VLLVWKDNEE 420

NFFAQCANLG DSACVIHLGG RYIQMTEDHR VVSLSERKRF QEAGLALRDG ETRLFGINLA 480

RMLGDKFPKQ QDSRFSAEPY ISEPLRIDQS SKDVFAVLAS DGLWDVVSPK KAVQLVLQMR 540

DKERGRESSA EKIANGLLNE ARAMRTKDNT SIIYLDFDTS L 581

Nucleotide Sequence
(FASTA)

ATGGCGATGA TAGGGATGAA CATTATTGGG CTATTCATGG TTCTTATGTT GCTTCTCATC 60

TCCCTCATCA TCCTTTTCGC CTGCAAGCCA TGGCGATATT TTTCTCGTTT CCGATCCTCC 120

TCTCGTTTTT CTTCTACCTT CAAGGTGGGG GATTTGCAGA GACCACTTAT TTCTGATGAT 180

GGAAATTTGA TCCAAGGACA AACCAGTGAG GTAACAAGGG AATATGATTT AGAGGGAGCT 240

TGCTACCAAA ATGATGGACT TTTGCATTCA TCTCTGACTG AGGGACGGTT TTACAAACAA 300

AGGCTTCCTT CGTCATCTCC CCATTTCTCC CAAGGTGAAA GCTTTGTTCT AGAAGTAATT 360

TCTGAACCTT CTGACAATGC TTTGGTGGGC CAAACGCTTA AACTTCCAGC TGAAAAAGGT 420

TCCTTGGCAG AAGTGCAAAC ATATGACTGG CAGAATAACA GAAATGAAAA CTTGCAATAT 480

AATCTGGAAA AGGATCGACT TATTAATCTT TCTCCGAGGC TCGTGGAAGA TCAAAGAAGT 540

TGGCTGTTCC TGGAAGTCAT CGCGGGTCCT GCCATTGGGC TTCAACATGC TGTGAACTCC 600

ACAAGTTCCT CCAAGCTGCC AGTGAAACTT GGAAGGGTTT CTCCTTCTGA TTTGGCATTG 660

AAGGACTCAG AAGTCTCTGG GAAACATGCA CAGATAACAT GGAACTCTAC TAAATTTAAA 720

TGGGAGCTGG TAGATATGGG TAGCCTAAAT GGAACTCTCG TAAACTCTCA TTCAATAAGT 780

CATCCTGATT TAGGCAGCCG GAAGTGGGGT AACCCTGTCG AGCTTGCAAG TGATGATATA 840

ATAACTTTGG GAACAACAAC AAAGGTCTAT GTCCGTATCT CCTCTCAGAA TGAGTTTCAG 900

ATACCCTTCA AAATTGGTGT GGCCTCAGAT CCCATGGCTA TGCGTCGAGG AGGCAGGAAA 960

CTTCCGATGG AAGATGTTTG TCATTACAAG TGGCCGCTTC CTGGGGCTAA TAAGTTTGGA 1020

CTGTTTTGTG TTTGTGATGG ACATGGGGGA TCAGGGGCTG CTCAATCCGC AATCAAAATT 1080

ATTCCGGAGG TTCTAGCGAA TATTTTATCA GACTCGCTGA GGAAGGAGAA AGTGTTATCA 1140

AAAAGGGATG CTTCGGACGT CCTTAGGGAC ATGTTTGCTA AAACAGAAGC TCGCCTCGAA 1200

GAACACCAAT ATGAGGGTTG TACAGCTACT GTTCTCTTGG TTTGGAAAGA CAATGAAGAA 1260

AACTTCTTCG CACAATGTGC CAATCTTGGG GATTCAGCAT GTGTTATCCA TCTTGGTGGC 1320

AGATATATAC AAATGACTGA AGATCATCGA GTGGTTAGCT TGAGCGAGAG AAAACGATTC 1380

CAAGAAGCAG GACTAGCCTT GAGAGATGGA GAGACTCGGC TTTTTGGTAT AAACCTTGCG 1440

AGGATGCTTG GAGACAAGTT TCCAAAGCAA CAAGACAGCC GTTTCAGTGC AGAGCCATAT 1500

ATAAGTGAGC CTTTGCGTAT CGATCAATCT AGTAAAGACG TATTTGCTGT ATTGGCTAGT 1560

GACGGGTTAT GGGACGTGGT AAGTCCGAAG AAAGCTGTGC AGCTTGTACT TCAGATGAGA 1620

GATAAAGAGA GAGGGAGAGA GAGTAGTGCG GAGAAGATAG CAAACGGTCT GCTGAATGAA 1680

GCTAGAGCGA TGCGTACAAA GGACAACACC TCCATTATTT ACTTAGATTT CGATACTTCC 1740

CTGTAA 1746

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdr................laffgvyDGhgg  46

         v+++s+n+++  ++  v+s p+++++ ++k                  + +f+v+DGhgg

Q: 291   VRISSQNEFQIPFKIGVASDPMAMRRGGRKLPmedvchykwplpgankFGLFCVCDGHGG  350

         6789999999999999********99999988999*************************

S: 47    sevakfcseklheilaeele.....sseseerkvkkalakaFlstdeelkvleeksldid  101

         s +a+ + + + e+la+ l+     ++  ++r+ +++l+++F++t+ +l       ++++

Q: 351   SGAAQSAIKIIPEVLANILSdslrkEKVLSKRDASDVLRDMFAKTEARL-------EEHQ  403

         ********************999988888999999**************.......6789

S: 102   ksGstavvalikds.....klyvanvGdSravLcrngkavelssdHkpsredEleRieea  156

          +G+ta+v l++++        +an+GdS +v++ +g  +++++dH++ + +E++R +ea

Q: 404   YEGCTATVLLVWKDneenfFAQCANLGDSACVIHLGGRYIQMTEDHRVVSLSERKRFQEA  463

         9***********99999988999**************99*********************

S: 157   ggsvilkdga.RvlGvLavsRalGdlylk...pyvtpePevtshrl..tsede.fliLas  209

         g   +l+dg+ R++G ++++R+lGd++ k   +  ++eP +++  +  +s+++ f +Las

Q: 464   G--LALRDGEtRLFG-INLARMLGDKFPKqqdSRFSAEPYISEPLRidQSSKDvFAVLAS  520

         9..88999999****.9************99889*********99988677778******

S: 210   DGlwdvvsneeavslvrdvle....kkeaeqeaakkLvklalargskdnvsaiv  259

         DGlwdvvs+++av+lv ++ +    ++++++++a+ L+++a+a+++kdn+s+i+

Q: 521   DGLWDVVSPKKAVQLVLQMRDkergRESSAEKIANGLLNEARAMRTKDNTSIIY  574

         *********************9999999***********************998

Domain Sequence
(FASTA)

VRISSQNEFQ IPFKIGVASD PMAMRRGGRK LPMEDVCHYK WPLPGANKFG LFCVCDGHGG 60

SGAAQSAIKI IPEVLANILS DSLRKEKVLS KRDASDVLRD MFAKTEARLE EHQYEGCTAT 120

VLLVWKDNEE NFFAQCANLG DSACVIHLGG RYIQMTEDHR VVSLSERKRF QEAGLALRDG 180

ETRLFGINLA RMLGDKFPKQ QDSRFSAEPY ISEPLRIDQS SKDVFAVLAS DGLWDVVSPK 240

KAVQLVLQMR DKERGRESSA EKIANGLLNE ARAMRTKDNT SIIY 284

Keyword

3D-structure; Alternative splicing; Complete proteome; Hydrolase; Magnesium; Manganese; Membrane; Metal-binding; Protein phosphatase; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Arabidopsis lyrata"; ?>Brachypodium distachyon"; ?>Brassica rapa"; ?>Glycine max"; ?>Hordeum vulgare"; ?>Musa acuminata"; ?>Oryza brachyantha"; ?>Oryza glaberrima"; ?>Oryza indica"; ?>Oryza sativa"; ?>Physcomitrella patens"; ?>Populus trichocarpa"; ?>Selaginella moellendorffii"; ?>Setaria italica"; ?>Solanum lycopersicum"; ?>Solanum tuberosum"; ?>Sorghum bicolor"; ?>Vitis vinifera"; ?>Zea mays"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

ath:AT5G19280

;

InterPros

IPR000253	; FHA_dom.
IPR016660	; Kinase_assoc_Pase.
IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.
IPR008984	; SMAD_FHA_domain.

Pfam

PF00498	; FHA; 1.
PF00481	; PP2C; 1.

SMARTs

SM00240	; FHA; 1.
SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS50006	; FHA_DOMAIN; 1.
PS01032	; PP2C; 1.

Prints

Created Date

20-Feb-2013