EKS-ART-00943

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ART-00943

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	327.3	1.9E-97	2363	2666	304

Status

Reviewed

Ensembl Protein

AT5G40820.1

UniProt Accession

Q9FKS4; Q9MAZ4;

Protein Name

Serine/threonine-protein kinase ATR

Protein Synonyms/Alias

AtATR; Ataxia telangiectasia-mutated and Rad3-related homolog; DNA repair protein ATR; Rad3-like protein; AtRAD3;

Gene Name

ATR

Gene Synonyms/Alias

ATR; RAD3; At5g40820; MHK7.5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
AT5G40820	AT5G40820.1	AT5G40820.1

Organism

Arabidopsis thaliana

Functional Description

Probable serine/threonine kinase. Plays a central rolein cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism. Seems to be required for the G2-phase checkpoint in response to replication blocks but not absolutely required in the G2-arrest response to double-strand breaks. May also be involved in the meiosis process. Required for the basal expression of RNR1 (ribonucleotide reductase large subunit). Acts in concert with telomerase to maintain telomeric DNA tracts. Not required for telomere length homeostasis.

Protein Length

2702

Protein Sequence
(FASTA)

MAKDDNNLSS LVHELRERVA ASASTPANNL RHSSGDEDAL EIRFRAVIPN LLNTYVVPSL 60

GNGREVTAVL KLVGHTARNI PGVFYHGTPS AILPVIARII PFFAEPEFVP GHGVLLETVG 120

SLLMLLRSNS RKAYRIFFHD ALQAIQDMQP IASLHSIEPE VCESHIPFRC FCMSFSGIGG 180

DLPDANKPRD GDGLVLNLLG ANRWQPFATC ILKLICKCLT EGTLYVQGLI HTSFFKAACS 240

LVCCGGADVQ MACFEFATLV GSILTFNILP HVALIQSIIL LLSADEGLPV YRNTIYDSTI 300

GRFLTAVYSS CSDAAVKLTA ESLVLVLSHA LQRTKSEELK ASLCSAYVRI VKSCPPCIWK 360

IHCLLELLHL PEPCFQLIEC FKAVLIVLGP GCVRVETTKC GSHTSATSDR PVQGINAGKK 420

RHIEDESTYK RKRQKVGDDI RRGVYFAPEF ADETDGKDAA SLREMLISTV ESLKPPPAGP 480

SLSQTESSIV ALSMLTNAFC FCPWTDMTHR LFNQMYAWIP WIAGQVEETN PIMFDISIYL 540

EGIHNLLLVG VDPQYEYTSK GNDLVAIQFL LKLPWTHYML FKTPSSLVKS KCLSVGIWTK 600

LGLQDGSDFD IFSWSLSDDF EQVQAVAAIS MPLKVLFSGL GALLHMFPKL EHLLEEKELM 660

IKKAIPQSLG FLSCLYGSST TDSEKTACHL LLHEDLKKDE TLNSLLQGFR CSKCDKFIER 720

EDEKHFRIIE TPEMVKLKMD HHRDYFNLQS LYFNLLYDES SEETQLACVE VIRRILGHTS 780

PDILVRTRSQ WIRCLQYLLV HVNTDVREAF CAQIGIFVQH PIVSCLFLSE DATEKSCERN 840

FFNLIEHSLA AAKDLLVIQT LLETTAEVMV AVDVTSELFL ICLFLLIDQL DHPNLIVRIN 900

ASKLINRSCY IHVKGGFATL LSTASHIQNE LFDNLSVRLT SRPNVVREFA EAVLGVETEE 960

LVRKMVPAVL PKLLVYWQEN AQAANTLNEL AKLIDTDVVP LIVNWLPRVL AFALNQEEDK 1020

NLLSVLQLYH SQIGSDNQEI FAAALPALLD ELVCFVDIAD TPETDRRLQR LPDAIKKISK 1080

VLTNAEDLPG FLQNHFVGLL NSIDRKMLHA DDIFLQKQAL KRIKLLIEMM GHYLSTYVPK 1140

LMVLLMHAIE KDALQSEGLL VLHFFTRKLA DVSPSSIKYV ISQIFAALIP FLEKEKEGPH 1200

VYLDEVVKIL EELVLKNRDI VKEHICEFPL LPSIPSLGEL NNAIQEARGL MSLKDQLRDI 1260

VNGMKHENLN VRYMVACELS KLLYNRNEDV AALIAGELVS DMEILSSLIT YLLQGCAEES 1320

RTTVGQRLKL VCADCLGAIG AIDPAKVRVA SCSRFKIQCS DDDLIFELIH KHLARAFRAA 1380

QDTIIQDSAA LAIQELLKIA GCEPSLAGNV VVLTPQEHVQ VNVSGSRRCG GNNEVKDRGQ 1440

KLWDRFSNYV KELIAPCLTS RFQLPNVSDP GSAGPIYRPS MSFRRWLSYW IRKLTAFATG 1500

SRVSIFAACR GIVRHDMQTA TYLLPYLVLD VVCHGTEAAR LSISEEILSV LDAAASENSG 1560

VTINSFGVGQ SEVCVQAVFT LLDNLGQWVD DVKQGVALSS SLQSSGGRQV APKSKDQVSN 1620

STTEQDHLLV QCKYVLELLL AIPKVTLARA SFRCQAYARS LMYLESHVRG KSGSLNPAAE 1680

KTGIFENADV SSLMGIYSCL DEPDGLSGFA SLSKSLNLQD QLLINKKSGN WADVFTACEQ 1740

ALQMEPTSVQ RHSDVLNCLL NMCHHQTMVT HVDGLISRVP EYKKTWCTQG VQAAWRLGKW 1800

DLMDEYLDGA DAEGLLFSSS DSNASFDRDV AKILHAMMKK DQYSVAEGIA ISKQALIAPL 1860

AAAGMDSYTR AYPFVVKLHL LRELEDFQAV LNGDSYLEKS FSTSDQVFSK AVDNWENRLR 1920

FTQSSLWTRE PLLAFRRLVF GASGLGAQVG NCWLQYAKLC RLAGHYETAH RAILEAQASG 1980

APNVHMEKAK LLWITKRSDS AIIELQQSLL NMPEGVVDST VISSINSLLM APPNPEPTVR 2040

NTQSFKEKKD VAKTLLLYSK WIHHSGQKQK KDVLNLYTQV KELLPWEKGY FHLAKYYDEL 2100

YVDARKCQQE SSVFSSAGSK KGSVSSNLST EKAGWDYLFK GMYFYAKALH SGHKNLFQAL 2160

PRLLTLWFDF GTIYKTSGSA GNKELKSTHM KIMSLMRGCL KDLPTYQWLT VLPQLVSRIC 2220

HQNADTVLMV KNIITSVLHQ FPQQGLWIMA AVSKSTVPAR REAAAEIIQG ARKGFNQSDR 2280

GHNLFIQFAS LTDHFIKLCF HGGQPRSKVI NIATEFSALK RMMPLDIIMP IQQSLTISLP 2340

AFHMNNNERH SASVFSGSDL PTISGIADEA EILSSLQRPK KIILLGNDGI EYPFLCKPKD 2400

DLRKDARMME FTAMINRLLS KYPESRRRKL YIRTFAVAPL TEDCGLVEWV PHTRGLRHIL 2460

QDIYISCGKF DRQKTNPQIK RIYDQCAVKK EYEMLKTKIL PMFPPVFHKW FLTTFSEPAA 2520

WFRSRVAYAH TTAVWSMVGH IVGLGDRHGE NILFDSTSGD CVHVDFSCLF DKGLQLEKPE 2580

LVPFRLTQNM IDGLGITGYE GIFMRVCEIT LTVLRTHRET LMSILETFIH DPLVEWTKSH 2640

KSSGVEVQNP HAQRAISSIE ARLQGVVVGV PLPVEGQARR LIADAVSLEN LGKMYIWWMP 2700

WF 2702

Nucleotide Sequence
(FASTA)

ATGGCGAAGG ACGACAATAA TCTGTCGAGC TTGGTTCACG AACTTCGTGA ACGGGTGGCC 60

GCATCCGCCT CCACTCCGGC TAACAACCTC CGTCACTCTT CCGGAGACGA AGATGCTCTA 120

GAGATTCGAT TTCGTGCTGT CATCCCTAAT CTATTGAATA CCTACGTTGT TCCTTCTCTC 180

GGCAACGGGA GGGAAGTTAC AGCTGTTCTG AAGCTTGTTG GTCACACAGC AAGGAACATT 240

CCAGGAGTCT TCTATCACGG AACCCCTTCT GCTATCCTCC CTGTGATTGC TCGTATTATT 300

CCCTTCTTTG CTGAACCAGA ATTTGTTCCT GGGCATGGAG TATTACTTGA AACTGTTGGC 360

TCTCTCTTAA TGTTGCTGCG TTCCAACTCA AGGAAGGCAT ACCGGATCTT CTTCCATGAC 420

GCTTTGCAGG CAATTCAAGA TATGCAACCT ATTGCATCAC TGCACTCAAT TGAACCGGAA 480

GTTTGTGAAT CTCACATTCC ATTTAGGTGT TTCTGTATGT CCTTTTCTGG AATTGGGGGT 540

GATCTGCCAG ATGCTAATAA GCCCAGAGAT GGTGATGGTC TTGTGTTGAA CTTATTGGGA 600

GCCAACCGAT GGCAACCTTT TGCTACTTGT ATTCTTAAAC TCATCTGTAA ATGCCTAACT 660

GAGGGGACAC TCTACGTCCA GGGTCTCATC CATACATCAT TTTTTAAGGC GGCTTGTTCT 720

CTAGTATGCT GTGGTGGCGC AGATGTGCAG ATGGCATGCT TTGAATTTGC TACTCTTGTC 780

GGATCAATCC TTACATTCAA CATCCTCCCG CATGTGGCCT TAATACAGTC AATCATCCTC 840

CTTTTAAGTG CAGATGAAGG ACTTCCTGTG TACAGGAATA CGATTTATGA TTCTACCATT 900

GGACGTTTCC TTACGGCAGT ATATTCCAGC TGTTCTGATG CCGCTGTCAA ACTAACTGCA 960

GAAAGTTTAG TGTTGGTTCT CTCTCATGCT TTACAGAGAA CAAAAAGTGA GGAGCTTAAG 1020

GCTTCCCTCT GCAGTGCATA TGTGCGGATT GTGAAATCTT GTCCTCCTTG TATATGGAAG 1080

ATACACTGCC TTCTAGAGTT GCTTCATCTT CCAGAACCTT GTTTTCAGTT GATAGAATGT 1140

TTTAAAGCAG TTCTTATAGT TCTTGGACCT GGGTGTGTTC GAGTTGAGAC AACCAAATGT 1200

GGTAGTCATA CATCAGCAAC AAGTGATAGA CCTGTCCAGG GAATTAACGC TGGAAAAAAA 1260

AGGCATATTG AGGATGAAAG TACATACAAA AGAAAGCGCC AGAAGGTTGG TGATGATATT 1320

CGACGAGGGG TTTACTTTGC TCCTGAATTT GCCGATGAGA CTGATGGAAA AGATGCTGCT 1380

AGTCTGCGTG AGATGCTTAT TTCAACTGTA GAATCTTTAA AGCCTCCACC TGCTGGACCT 1440

AGTCTGTCAC AGACTGAAAG TTCAATAGTG GCACTTAGCA TGCTCACCAA TGCATTTTGT 1500

TTCTGTCCCT GGACTGACAT GACTCATCGA TTGTTTAACC AGATGTATGC CTGGATTCCC 1560

TGGATAGCTG GGCAGGTTGA GGAAACAAAT CCTATCATGT TCGATATTTC CATTTACTTG 1620

GAAGGAATTC ACAATCTGCT GCTCGTTGGT GTGGATCCAC AGTATGAATA TACAAGTAAA 1680

GGGAATGATC TGGTTGCCAT ACAATTCTTG CTGAAGCTTC CTTGGACGCA CTACATGCTG 1740

TTTAAGACGC CTAGCTCTCT AGTAAAGTCT AAGTGTTTAT CTGTAGGGAT ATGGACAAAG 1800

CTTGGTTTAC AAGACGGGAG TGATTTTGAT ATCTTCAGTT GGTCTCTTTC TGATGATTTT 1860

GAACAAGTGC AAGCTGTCGC TGCTATCTCT ATGCCACTCA AAGTTCTTTT CTCTGGTCTT 1920

GGTGCCCTTC TTCATATGTT CCCCAAGCTG GAGCATTTGT TGGAAGAAAA GGAATTGATG 1980

ATTAAGAAGG CCATTCCTCA GTCACTTGGC TTCTTATCTT GTCTTTATGG ATCAAGTACT 2040

ACTGACTCAG AGAAAACTGC ATGCCATTTA CTCCTACATG AAGATTTAAA GAAAGATGAG 2100

ACTCTGAATT CTCTACTTCA AGGGTTCCGA TGTTCAAAGT GTGATAAATT TATCGAACGC 2160

GAAGATGAAA AGCATTTCAG AATCATAGAG ACTCCAGAGA TGGTGAAATT GAAGATGGAT 2220

CATCATCGTG ATTACTTTAA CCTTCAATCT TTATATTTTA ATCTTCTCTA TGATGAGTCT 2280

TCTGAAGAGA CTCAGCTAGC CTGCGTAGAA GTAATAAGGA GAATTCTTGG CCACACATCC 2340

CCAGATATTC TGGTAAGAAC AAGGTCTCAA TGGATCAGGT GCCTTCAATA TCTATTAGTT 2400

CATGTAAATA CAGACGTAAG GGAAGCATTC TGTGCTCAGA TTGGTATCTT CGTACAGCAT 2460

CCTATTGTGA GCTGTTTGTT TCTTAGTGAA GATGCTACGG AGAAAAGTTG CGAAAGAAAT 2520

TTTTTTAATT TGATTGAGCA TTCTCTAGCA GCAGCTAAGG ATCTTCTTGT TATCCAGACT 2580

CTATTGGAAA CGACAGCTGA AGTTATGGTA GCTGTTGATG TTACCAGTGA GCTTTTCTTG 2640

ATTTGTCTTT TCCTGCTGAT TGATCAGCTT GATCATCCAA ACTTGATCGT CCGAATAAAT 2700

GCGTCAAAGT TAATAAATCG GTCATGCTAC ATCCACGTGA AAGGGGGATT TGCAACTCTA 2760

CTTTCCACAG CCTCTCATAT TCAAAATGAG TTGTTTGATA ATCTATCTGT CAGGCTGACC 2820

AGCCGTCCAA ATGTGGTAAG AGAATTTGCA GAAGCTGTTT TGGGTGTTGA AACTGAAGAA 2880

CTTGTGAGGA AAATGGTCCC TGCTGTTCTT CCTAAGCTCT TGGTGTATTG GCAGGAAAAT 2940

GCTCAAGCAG CCAATACCTT GAACGAACTG GCCAAGTTAA TAGACACAGA TGTGGTACCT 3000

CTAATAGTAA ATTGGCTACC CAGAGTTCTT GCATTTGCTC TGAATCAAGA AGAGGACAAG 3060

AATTTGCTCT CAGTTTTGCA ATTGTATCAC TCACAGATTG GTTCTGACAA CCAAGAAATT 3120

TTTGCTGCTG CATTACCTGC ACTCTTAGAT GAGCTTGTAT GCTTTGTGGA CATTGCTGAT 3180

ACACCTGAGA CAGATAGACG GCTACAGAGA CTGCCTGATG CAATAAAGAA GATCTCAAAA 3240

GTTTTAACAA ATGCCGAGGA TCTTCCTGGA TTCTTACAAA ACCATTTTGT TGGACTCCTT 3300

AACAGTATTG ACAGAAAAAT GCTTCATGCA GATGACATTT TTCTTCAAAA ACAAGCACTG 3360

AAGCGTATTA AACTGCTCAT TGAGATGATG GGCCATTATC TCAGCACATA TGTTCCTAAG 3420

CTTATGGTTC TCCTTATGCA TGCCATTGAA AAAGATGCAC TTCAGAGCGA GGGTCTCTTG 3480

GTCTTGCATT TTTTTACAAG AAAGTTGGCT GATGTATCGC CATCTAGCAT AAAGTATGTG 3540

ATTTCTCAGA TTTTTGCGGC ACTCATCCCC TTCTTAGAGA AAGAGAAGGA AGGTCCCCAT 3600

GTATATTTAG ATGAAGTGGT GAAAATTCTT GAAGAACTTG TTTTGAAGAA TAGAGATATA 3660

GTAAAAGAGC ATATTTGTGA GTTTCCCCTC TTACCTAGCA TACCATCTTT AGGAGAATTA 3720

AACAATGCTA TTCAAGAAGC ACGTGGATTA ATGAGCCTGA AGGATCAGTT GCGGGATATT 3780

GTAAATGGTA TGAAACACGA GAACCTGAAT GTTAGATACA TGGTGGCATG TGAGCTAAGC 3840

AAATTGCTGT ATAACAGAAA TGAAGATGTT GCTGCACTGA TTGCCGGTGA ACTTGTCTCA 3900

GACATGGAGA TCTTGAGCTC TTTAATCACA TATTTACTAC AGGGGTGTGC AGAAGAATCT 3960

CGAACTACAG TGGGCCAGAG GTTGAAGTTA GTCTGTGCAG ATTGTCTTGG AGCAATAGGT 4020

GCTATTGACC CTGCCAAAGT GAGAGTTGCT TCATGCAGTC GTTTTAAAAT CCAATGCTCA 4080

GATGATGATC TTATCTTTGA GCTCATTCAC AAACACTTGG CAAGAGCTTT TAGAGCTGCA 4140

CAGGATACAA TAATACAAGA CTCAGCTGCT CTTGCCATAC AGGAACTACT AAAGATTGCT 4200

GGTTGTGAGC CATCATTAGC TGGGAATGTT GTTGTGTTGA CCCCCCAGGA GCATGTACAA 4260

GTCAATGTAT CTGGTTCTAG AAGATGTGGA GGTAACAATG AAGTGAAGGA TAGGGGACAA 4320

AAACTATGGG ATCGGTTCTC AAACTATGTT AAAGAACTAA TAGCTCCCTG CTTGACTTCA 4380

AGGTTTCAGC TTCCAAATGT GTCTGACCCT GGATCAGCTG GACCAATTTA TCGGCCTTCT 4440

ATGTCATTCA GAAGGTGGCT ATCCTACTGG ATAAGGAAAT TGACAGCATT TGCAACTGGA 4500

TCCCGTGTAA GCATATTTGC TGCTTGCCGA GGCATAGTGC GTCACGATAT GCAGACAGCT 4560

ACTTATCTCT TACCATATTT AGTTCTGGAT GTTGTTTGCC ATGGGACTGA GGCAGCACGG 4620

CTTAGCATTT CTGAAGAGAT CCTTTCTGTT CTTGATGCTG CTGCATCAGA AAATAGTGGA 4680

GTGACAATAA ACAGTTTTGG TGTTGGTCAG AGTGAAGTTT GTGTTCAAGC TGTTTTCACG 4740

CTTCTTGATA ACCTTGGGCA ATGGGTTGAC GATGTGAAGC AGGGAGTAGC ACTCTCATCG 4800

TCTCTGCAGT CATCAGGTGG TAGGCAAGTA GCACCCAAAT CGAAAGACCA GGTTTCAAAC 4860

TCAACAACAG AACAGGATCA TCTTCTTGTA CAATGTAAAT ATGTGTTGGA ACTTTTGCTA 4920

GCTATTCCCA AGGTGACCCT TGCTAGGGCA TCTTTCAGGT GTCAAGCTTA TGCCAGGTCA 4980

TTGATGTACC TTGAATCCCA TGTACGTGGA AAGTCAGGCT CCTTAAATCC CGCAGCTGAG 5040

AAGACCGGCA TCTTTGAAAA TGCTGATGTT TCTTCTCTGA TGGGAATATA CAGCTGCCTT 5100

GACGAGCCAG ACGGTCTTTC GGGCTTTGCA AGTTTAAGCA AATCATTAAA TTTGCAAGAC 5160

CAGTTGTTGA TAAACAAGAA ATCTGGTAAC TGGGCAGACG TTTTTACTGC ATGTGAACAA 5220

GCCCTTCAGA TGGAACCAAC ATCAGTTCAA CGACATTCAG ATGTTCTTAA TTGTTTACTT 5280

AACATGTGCC ACCATCAGAC AATGGTCACT CATGTTGACG GACTAATTTC CAGAGTACCT 5340

GAGTACAAGA AAACGTGGTG CACACAAGGT GTACAAGCTG CATGGAGACT CGGAAAGTGG 5400

GACTTGATGG ATGAGTATCT TGATGGAGCT GATGCAGAAG GTTTACTATT CAGTAGCTCA 5460

GACAGCAATG CCTCATTCGA TAGAGATGTA GCAAAGATTC TCCATGCAAT GATGAAGAAG 5520

GATCAATACT CTGTAGCTGA GGGAATAGCT ATTTCCAAAC AAGCTCTCAT TGCTCCTCTA 5580

GCTGCAGCAG GCATGGACTC CTACACACGA GCTTATCCTT TTGTTGTCAA ACTTCACTTG 5640

CTAAGAGAGC TAGAGGACTT CCAGGCGGTT CTTAATGGGG ATTCATATTT GGAGAAATCA 5700

TTTAGTACAA GTGATCAGGT GTTTTCGAAA GCAGTAGATA ACTGGGAGAA TCGGCTCAGA 5760

TTTACTCAAT CATCACTGTG GACAAGGGAA CCTCTCTTAG CTTTCCGAAG ACTCGTCTTT 5820

GGTGCCTCTG GTCTTGGTGC TCAAGTTGGG AACTGTTGGC TTCAATATGC AAAGCTTTGC 5880

CGTTTGGCTG GACACTATGA GACAGCTCAC AGGGCAATTT TGGAAGCTCA GGCTTCTGGT 5940

GCACCTAATG TTCACATGGA AAAGGCGAAA CTTCTTTGGA TCACTAAGCG TTCAGACAGT 6000

GCAATTATAG AGCTACAACA ATCTCTCCTG AATATGCCTG AGGGTGTTGT TGACTCCACT 6060

GTAATTTCTT CGATCAATAG CTTACTGATG GCTCCCCCAA ATCCAGAGCC CACAGTTCGT 6120

AACACACAAT CTTTCAAAGA AAAAAAAGAT GTCGCAAAGA CTCTTCTTTT GTATTCCAAA 6180

TGGATCCATC ACAGTGGGCA GAAACAAAAG AAAGATGTTT TAAATCTGTA TACCCAAGTC 6240

AAGGAATTGC TGCCCTGGGA GAAGGGATAT TTCCATTTGG CTAAGTATTA TGATGAACTA 6300

TATGTTGATG CAAGAAAGTG TCAACAAGAG AGCTCTGTAT TTAGCTCTGC AGGCAGTAAA 6360

AAAGGATCTG TCTCGTCGAA CTTAAGCACT GAGAAAGCAG GGTGGGATTA CCTGTTTAAG 6420

GGAATGTACT TCTATGCTAA GGCACTTCAC AGTGGACACA AGAATCTCTT TCAAGCACTT 6480

CCGAGGTTGT TAACACTGTG GTTTGACTTT GGTACTATCT ATAAAACAAG TGGCTCAGCG 6540

GGAAATAAGG AATTGAAAAG TACTCATATG AAGATAATGA GTTTAATGAG GGGCTGCTTA 6600

AAGGATCTGC CAACCTATCA ATGGTTAACT GTGTTGCCCC AGTTGGTTTC TCGAATCTGT 6660

CACCAGAATG CGGATACAGT ACTAATGGTT AAAAATATCA TCACTTCTGT TCTACATCAA 6720

TTTCCTCAGC AAGGGCTCTG GATTATGGCA GCTGTTTCAA AATCTACTGT TCCTGCTAGA 6780

AGGGAAGCAG CTGCAGAAAT CATACAAGGT GCACGAAAAG GTTTTAACCA AAGTGACAGA 6840

GGCCACAATT TGTTCATTCA GTTTGCTAGT TTGACTGATC ATTTCATTAA ACTATGCTTC 6900

CATGGAGGAC AACCAAGATC CAAGGTTATC AATATAGCAA CTGAATTCAG TGCCTTGAAA 6960

AGAATGATGC CGCTGGATAT CATCATGCCA ATTCAACAAT CTCTTACCAT TAGCCTACCA 7020

GCATTCCATA TGAATAACAA TGAACGACAC TCTGCCAGTG TCTTTTCTGG TTCAGATCTA 7080

CCAACTATTT CTGGTATAGC CGATGAAGCC GAGATACTTT CTTCCCTTCA GCGCCCAAAG 7140

AAGATCATTC TGCTGGGAAA TGATGGTATT GAGTATCCAT TCCTCTGCAA GCCCAAGGAT 7200

GATCTCAGGA AAGATGCTCG GATGATGGAA TTTACTGCGA TGATAAACCG CTTACTATCC 7260

AAGTATCCCG AAAGCAGACG AAGGAAGCTA TATATCCGCA CCTTCGCAGT AGCTCCTCTG 7320

ACTGAGGACT GTGGTCTGGT CGAGTGGGTT CCACATACAC GTGGACTCCG CCATATTCTA 7380

CAAGATATAT ACATTTCCTG TGGGAAGTTT GATCGGCAGA AAACAAATCC TCAAATTAAA 7440

AGAATATATG ATCAATGTGC TGTTAAAAAG GAGTATGAGA TGCTGAAGAC CAAAATCCTC 7500

CCTATGTTCC CTCCGGTTTT CCATAAATGG TTCTTGACAA CGTTTTCTGA ACCAGCTGCT 7560

TGGTTTAGGT CACGTGTAGC TTATGCTCAC ACCACAGCAG TTTGGTCCAT GGTTGGGCAC 7620

ATTGTTGGGC TTGGTGACCG TCATGGAGAA AATATTCTCT TTGATTCTAC TTCGGGTGAT 7680

TGTGTTCATG TAGACTTCAG TTGCTTATTT GACAAAGGCT TACAACTGGA GAAGCCTGAG 7740

TTGGTGCCAT TCAGATTGAC CCAGAACATG ATTGATGGTT TGGGCATCAC TGGATATGAG 7800

GGCATCTTCA TGAGGGTATG TGAAATCACT CTCACAGTGT TGAGGACACA TAGGGAGACG 7860

TTGATGAGCA TCCTGGAGAC ATTCATCCAT GATCCTCTTG TGGAGTGGAC AAAGTCACAC 7920

AAATCAAGCG GAGTAGAAGT TCAGAACCCA CATGCTCAGC GGGCCATAAG CAGCATTGAA 7980

GCCCGGCTGC AGGGCGTGGT TGTTGGTGTT CCGCTACCGG TAGAAGGTCA GGCTCGCCGG 8040

TTGATTGCCG ATGCAGTCTC ACTTGAGAAT CTTGGGAAGA TGTACATCTG GTGGATGCCC 8100

TGGTTCTGA 8109

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i g++++ eil+s+q+pkk++l+G+dg eyp+L+k+k+Dlr+d+r++++  ++N lL k

Q: 2363  ISGIADEAEILSSLQRPKKIILLGNDGIEYPFLCKPKDDLRKDARMMEFTAMINRLLSKY  2422

         67999*******************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +e++rrkL irt++V pl++ +gl+ewv++t +L+++l++++ + +           k +

Q: 2423  PESRRRKLYIRTFAVAPLTEDCGLVEWVPHTRGLRHILQDIYISCGKFDR------QKTN  2476

         **************************************876655544443......3444

S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180

         ++++ r  +  ++k+++e++k    ++ p+ +++k++l +f +p++wf++r ay+  +Av

Q: 2477  PQIK-RIYDQCAVKKEYEMLKTKILPMFPP-VFHKWFLTTFSEPAAWFRSRVAYAHTTAV  2534

         4444.44455566666799999999*9998.*****************************

S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240

          s+vg+i+gLgdrh en+l+d+++g +vh+df + f+k+ + l+ pe vPFRLT+n++++

Q: 2535  WSMVGHIVGLGDRHGENILFDSTSGDCVHVDFSCLFDKGLQ-LEKPELVPFRLTQNMIDG  2593

         *****************************************.******************

S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeeelaek  300

         lg+tg eG+f + ce +l vlr ++e+l++iLe+f++dplv+w+k++k+s    e+ ++

Q: 2594  LGITGYEGIFMRVCEITLTVLRTHRETLMSILETFIHDPLVEWTKSHKSS--GVEVQNPH  2651

         ********************************************833332..23333344

S: 301   akaealkikkllskv  315

         a+     i+ +l++v

Q: 2652  AQRAISSIEARLQGV  2666

         444444555555555

Domain Sequence
(FASTA)

ISGIADEAEI LSSLQRPKKI ILLGNDGIEY PFLCKPKDDL RKDARMMEFT AMINRLLSKY 60

PESRRRKLYI RTFAVAPLTE DCGLVEWVPH TRGLRHILQD IYISCGKFDR QKTNPQIKRI 120

YDQCAVKKEY EMLKTKILPM FPPVFHKWFL TTFSEPAAWF RSRVAYAHTT AVWSMVGHIV 180

GLGDRHGENI LFDSTSGDCV HVDFSCLFDK GLQLEKPELV PFRLTQNMID GLGITGYEGI 240

FMRVCEITLT VLRTHRETLM SILETFIHDP LVEWTKSHKS SGVEVQNPHA QRAISSIEAR 300

LQGV 304

Keyword

ATP-binding; Cell cycle; Complete proteome; DNA damage; DNA repair; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Arabidopsis lyrata"; ?>Brachypodium distachyon"; ?>Brassica rapa"; ?>Chlamydomonas reinhardtii"; ?>Cyanidioschyzon merolae"; ?>Glycine max"; ?>Hordeum vulgare"; ?>Musa acuminata"; ?>Oryza brachyantha"; ?>Oryza glaberrima"; ?>Oryza indica"; ?>Oryza sativa"; ?>Physcomitrella patens"; ?>Populus trichocarpa"; ?>Selaginella moellendorffii"; ?>Setaria italica"; ?>Solanum lycopersicum"; ?>Sorghum bicolor"; ?>Vitis vinifera"; ?>Zea mays"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0009506	; C:plasmodesma
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006281	; P:DNA repair
GO:0007126	; P:meiosis
GO:0032504	; P:multicellular organism reproduction
GO:0032204	; P:regulation of telomere maintenance
GO:0010044	; P:response to aluminum ion
GO:0010332	; P:response to gamma radiation
GO:0043247	; P:telomere maintenance in response to DNA damage
GO:0007004	; P:telomere maintenance via telomerase

KEGG

ath:AT5G40820

;

InterPros

IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.
IPR012993	; UME.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08064	; UME; 1.

SMARTs

SM00146	; PI3Kc; 1.
SM00802	; UME; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; FALSE_NEG.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013