| Tag | Content |
|---|
| EKPD ID | EKS-CAE-00363 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Other/Aur | 440.7 | 1.8E-132 | 30 | 280 | 251 |
|
| Status | Reviewed |
| Ensembl Protein | B0207.4 |
| UniProt Accession | O01427; |
| Protein Name | Aurora/IPL1-related protein kinase 2 |
| Protein Synonyms/Alias | Serine/threonine-protein kinase aurora-B; |
| Gene Name | air-2 |
| Gene Synonyms/Alias | air-2; stu-7; B0207.4; |
| Ensembl Information | |
| Organism | Caenorhabditis elegans |
| Functional Description | Serine/threonine-protein kinase which mediates bothmeiotic and mitotic chromosome segregation. Required for histone H3 'Ser-10' phosphorylation. Phosphorylates tlk-1 at 'Ser-634', which enhances its activity. Phosphorylates zen-4 at 'Ser-680'. |
| Protein Length | 305 |
Protein Sequence
(FASTA) | | MENKPPVINL PEKETVNTPQ KGGKFTINDF EIGRPLGKGK FGSVYLARTK TGHFHVAIKV 60 | | LFKSQLISGG VEHQLEREIE IQSHLNHPNI IKLYTYFWDA KKIYLVLEYA PGGEMYKQLT 120 | | VSKRFSEPTA AKYMYEIADA LSYCHRKNVI HRDIKPENLL IGSQGELKIG DFGWSVHAPS 180 | | NKRQTMCGTM DYLPPEMVNG ADHSDAVDLW AIGVLCYEFL VGKPPFEHED QSKTYAAIKA 240 | | ARFTYPDSVK KGARDLIGRL LVVDPKARCT LEQVKEHYWI QGMMEAKIRA EKQQKIEKEA 300 | | SLRNH 305 |
|
Nucleotide Sequence
(FASTA) | | ATGGAGAATA AGCCACCTGT AATCAACCTT CCAGAGAAGG AAACTGTGAA TACTCCACAG 60 | | AAGGGAGGAA AATTTACTAT TAACGATTTC GAGATCGGAA GACCACTGGG AAAAGGAAAA 120 | | TTCGGCAGTG TTTACCTGGC TCGCACAAAA ACTGGACATT TCCATGTAGC GATCAAGGTT 180 | | CTATTCAAAT CGCAACTCAT CTCAGGAGGC GTCGAGCATC AATTGGAGCG TGAAATTGAG 240 | | ATTCAATCTC ATTTGAATCA CCCGAATATT ATCAAGCTCT ACACATATTT TTGGGATGCG 300 | | AAGAAGATCT ATCTCGTTTT GGAATATGCC CCCGGAGGCG AAATGTACAA GCAATTGACA 360 | | GTGAGCAAGA GATTCTCAGA GCCAACAGCT GCAAAATATA TGTATGAGAT CGCAGATGCT 420 | | TTGTCATATT GCCACAGGAA AAATGTGATT CATCGCGACA TTAAACCGGA GAATTTGCTT 480 | | ATCGGATCAC AAGGAGAATT GAAAATTGGA GATTTTGGAT GGAGTGTTCA TGCTCCTTCG 540 | | AATAAGCGCC AAACAATGTG CGGAACAATG GACTATCTCC CTCCTGAAAT GGTGAATGGA 600 | | GCCGATCACA GTGACGCAGT TGACTTATGG GCAATCGGCG TTCTCTGCTA TGAGTTTCTC 660 | | GTTGGAAAAC CCCCATTCGA GCACGAAGAT CAGTCCAAGA CATATGCGGC AATCAAAGCG 720 | | GCACGGTTTA CTTACCCTGA TTCTGTGAAG AAGGGTGCAC GAGATTTGAT TGGAAGATTG 780 | | CTTGTCGTTG ATCCCAAGGC TCGCTGTACG CTTGAACAGG TGAAGGAACA CTACTGGATC 840 | | CAGGGAATGA TGGAGGCAAA AATTAGAGCT GAGAAGCAGC AAAAGATTGA AAAAGAAGCA 900 | | AGTCTTCGGA ATCACTGA 918 |
|
| Domain Profile | S: 1 feiGrklGkGkfGnvylarekkskfivalkvlfkeqlekegvekqlrreieiqshlkhpn 60 | feiGr+lGkGkfG+vylar+k+ +f+va+kvlfk+ql++ gve+ql+reieiqshl+hpn | Q: 30 FEIGRPLGKGKFGSVYLARTKTGHFHVAIKVLFKSQLISGGVEHQLEREIEIQSHLNHPN 89 | 9*********************************************************** |
| S: 61 ilrlygyfhdekrvylileyaprGelykelqkskkldeqraakyieeladalsylhkkkv 120 | i++ly+yf+d+k++yl+leyap Ge+yk+l+ sk+++e +aaky++e+adalsy+h+k+v | Q: 90 IIKLYTYFWDAKKIYLVLEYAPGGEMYKQLTVSKRFSEPTAAKYMYEIADALSYCHRKNV 149 | ************************************************************ |
| S: 121 ihrdikpenlllgskgelkladfGwsvhapsskrktlcGtldylppemvegreydekvdl 180 | ihrdikpenll+gs+gelk++dfGwsvhaps+kr+t+cGt+dylppemv+g +++++vdl | Q: 150 IHRDIKPENLLIGSQGELKIGDFGWSVHAPSNKRQTMCGTMDYLPPEMVNGADHSDAVDL 209 | ************************************************************ |
| S: 181 walGvlcyellvGkppfeseskdetykrikkvdlklpssvskgakdliskllkkepkerl 240 | wa+Gvlcye+lvGkppfe+e++++ty+ ik++++++p+sv+kga+dli++ll ++pk+r+ | Q: 210 WAIGVLCYEFLVGKPPFEHEDQSKTYAAIKAARFTYPDSVKKGARDLIGRLLVVDPKARC 269 | ************************************************************ |
| S: 241 tladvlahpwi 251 | tl++v++h+wi | Q: 270 TLEQVKEHYWI 280 | **********8 |
|
Domain Sequence
(FASTA) | | FEIGRPLGKG KFGSVYLART KTGHFHVAIK VLFKSQLISG GVEHQLEREI EIQSHLNHPN 60 | | IIKLYTYFWD AKKIYLVLEY APGGEMYKQL TVSKRFSEPT AAKYMYEIAD ALSYCHRKNV 120 | | IHRDIKPENL LIGSQGELKI GDFGWSVHAP SNKRQTMCGT MDYLPPEMVN GADHSDAVDL 180 | | WAIGVLCYEF LVGKPPFEHE DQSKTYAAIK AARFTYPDSV KKGARDLIGR LLVVDPKARC 240 | | TLEQVKEHYW I 251 |
|
| Keyword | ATP-binding; Cell cycle; Cell division; Chromatin regulator; Chromosome; Chromosome partition; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Kinase; Meiosis; Mitosis; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |