EKS-CAE-00082

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00082

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	359.6	2.6E-107	2327	2617	291

Status

Reviewed

Ensembl Protein

B0261.2a.1

UniProt Accession

Q95Q95; O01438;

Protein Name

Target of rapamycin homolog

Protein Synonyms/Alias

CeTOR; Lethal protein 363;

Gene Name

let-363

Gene Synonyms/Alias

let-363; tor; B0261.2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
B0261.2	B0261.2b.2	B0261.2b.2
B0261.2	B0261.2b.1	B0261.2b.1
B0261.2	B0261.2a.1	B0261.2a.1
B0261.2	B0261.2a.2	B0261.2a.2

Organism

Caenorhabditis elegans

Functional Description

Kinase that regulates the mRNA translation machinery,probably by modulating the activity of translation factors such as eIF-4G and eIF-2. It may have some protein kinase activity instead of lipid kinase activity. May act as a mediator of lifespan regulation by insulin signaling and nutrient sensing.

Protein Length

2695

Protein Sequence
(FASTA)

MLQQHGISFQ MNADRQNKAA TTSNRIVSAP ATNEFDERHR KQGIDAARAL ASQYRSRITE 60

NRDANQRQAA RELSRYVRSE LKDEPNTFSD AFLNAIDGRT DIASQSAIYN CMKSNSNIDQ 120

KRAGIYLIVC LAETHSGNVI RYANYLLKML NNGNGLDEDT VKMASKALAF LIATCKSYAA 180

ELVDRCLDHC HEWLGQNVPH SQQPKNQQEI DQIRRLAASH LSRELALATP TAFFLRVNLF 240

FKYIFNAVRD KNPAVRIAGI DALHVVLTIV SQREAKNKTE WFKKCFDEAL EGQPNPSQKD 300

DLDRWHAVAL ILNELLRISD QRFELIRCES SQFIKQKFLK EDEEEGVEWL VLTKQQTIVE 360

SVTARKLVLE RFPKILDCVR QIIPLANKTS STKQQSSIYL NTVLMQLLPR ICAFPQCDRT 420

FQTISFDTSF TILQRNAVAA PAIGMMMLSN PDVHATHIEK TISFISAAIK KTTNSDVLDN 480

YFTFLFLFVD AYHEQVTTQI KAIIPQLMDI TLSRSLANVL KMIMMRIPKL RLNVQDGVMA 540

SVYQTLTGSL IPPKSEPIGR PASPKAILQK AETDPKELQR IVLAVDVLGE FYFSRGALQR 600

IMQYVADYYL TADNVEIRLA AVSSCCEMVV PFVGVYKKVT SDKRNSLLQT IYGVLRAVCS 660

VIVNDQDVRV RMQVISCFGQ MPRPFLAHLA QPEMLEVQFM ALHDEKLEMQ QACVTLLGRL 720

AELNPALVLP RLRLMLLETL SQMQQSGQAR LEQHSAKMIA QLAKQSPKFM RPYVGSLMIA 780

MIPKLRNDQK YAEVTAQVLN AVSEIAVIGG AEIVKNLKPL FEKLTHMIND SSSLHKREAA 840

LRAIGGICRS TAYVVDPYRD YPSLLDDLLR ILKTVMSNTM RREAIKTLGI LGAIDPYTHK 900

VFTGSVQSST AISTALSLPI SETDSKDPRQ DIIHWFNYEK CTLEEFYPAI TIANLMLMMQ 960

DEDSQSYAEI AQAIVTIFRS LGDMAPLYTE QVIPRLIEVC RRATESSNRA NLREFFLQQL 1020

ANFVAIIRKH AAPYMPAIFT IIADAWKEDI SVKMVVIEVL TDMGTAIGND FSKYTGELIP 1080

YLLTVLQTDK TKERVLTVKV MESIQKLTHC IVQHLHLVLP PLLIILDDFS LKLSIRNTAL 1140

STVLHMTQQV DVSAYAPRMM QSWHHNISTA EMRDKLLLLL IEIIKQLGKF FDIFKRGVDQ 1200

KLRDYNLDKS VHYEQYRKLA QRAQMSRDVL TSSVFAGSNG NIQYSSTQAG MRGQANNVYA 1260

NNDLHERLMN GSIDSGASRQ DNRDDYYRYG VEEKISEEVP KVAPTTARPT SELVTVQITK 1320

QRLNKDALMP QWKNENLTSK DEWLQWLMKI RIGFLTYGSS PSLRAASSLG DQHPHLARDL 1380

FPAAFMSVWT ELDSDVQNDL TSCLLRAIST GIPELIQTIL NLAEFMDHSE KGPLPISHDV 1440

LGRWAEQTKA FAKACRYKEM SVLKKSGSMQ TTFTRKVKLE PNDCQSLITY ANKLNVQEEA 1500

AGVVRYAERN EMNFQMRGRW YEKLNEWEKA LGAYELEEKK KSSCPNLQVY DEKDHLMTPE 1560

EAATAEEARM HEMRCLEALG RWDELNSKSV VWADQRGNRN DSVRDEINKK QLDHKMAVIA 1620

ARGAWAVDNW ERMADYVSVI SENTQDGAML RAVVAVHNDE NTKAMGLIEK VREMIDSELT 1680

AMANESYERA YIPMVSVQQM AELEEAIEYK TRPERRPRIA LLWSRRLQGC RRNVEQWQRL 1740

IMLRGLVLSP QEMHPLRVKF SSMCRKQGKN SMSRAVLREL LSLPANSDLV RAKAPFDKPL 1800

LVLALAKQLY QDDHKDEAIR ALEDLANHWN KRINPIPKAT GRELIPPSTK EPARICAKVL 1860

LKLGEWTELK SKTSNNMQVG ELSFVRQQVS PQYRTKESRT PETIAFENTI NYYQQATQYD 1920

PGWHKVWHKL ASTHFYAVCR ERPHPTTVIS PPQQPQQPKK MHIPPVTRAT SPPPPAQKSP 1980

QPAPFHSITE PLSVIIDYPV PPPLGSLVGL PPMPAYLSSN SSLPPQHHHV SPLSNDSPSN 2040

SAENKLYLKH AAHAVRCFAK ALMCSPGSRL EDTLRLMQLW FDHGDDKDQD VYFALTETIF 2100

DLPVTTWLEA IPQLMARLDC PDDQKSVQLV LRVLCEIARH RPQAVIYALT VASRSKDVHR 2160

SKNAGTVLEK MMEYHSKLVR EASLVTEELV RCAILWHEQW HDALDDASRV YFHDNNVQAM 2220

FDALRNMNDL MQKGAPTTMK EHSFQQTYSS DLKEAGRYVQ AFESSGNVKD LNQAWEIYCS 2280

VFKKLRDQLA TLNSLDLVYV SPNLVSAKDL ELVVPGTYDP SAPIVSIQSF SSKMNVITSK 2340

QRPRKMVIRG SNGLDYQFLL KGHEDPRQDE RVMQLFGLVN TLLANNSETC RRNLTIQRYS 2400

IVALSKDSGL IGWVPNCDTL HTLVKEYREK KAKIPLSIEH KTLQKLSLET EHLTLMQKLQ 2460

LFESALSVTQ GEDLRHVLWL KSPSSEVWFD RRTNYTRSVA CMSMVGYILG LGDRHPSNLM 2520

LDRLTGKVVH IDFGDCFEVA MLREKFPERV PFRLTRMLIN AMEVTGLDGV YNYTAERVLK 2580

MLRTNQESLL AVLEAFVYDP VINWRLVEGM KKDPKTRKDT GGRQNMAGAV LPSSSTTDSI 2640

METIKRKLDG TEFVHTDGST PPEPLQVTEQ LAMLTEQATS PLNLCQSYIG WCPFW 2695

Nucleotide Sequence
(FASTA)

ATGCTCCAAC AACACGGAAT TAGTTTTCAA ATGAATGCCG ATAGACAGAA CAAAGCAGCC 60

ACAACTTCCA ATCGAATAGT CTCCGCTCCA GCTACAAATG AATTTGACGA GCGGCATCGT 120

AAACAAGGGA TTGATGCTGC AAGAGCTCTT GCTTCACAAT ATCGGAGCCG AATTACGGAA 180

AATAGAGATG CAAATCAACG ACAGGCTGCT CGAGAACTCA GCAGATATGT TCGAAGTGAG 240

CTGAAAGACG AGCCAAATAC TTTTAGTGAT GCTTTCCTGA ATGCAATCGA TGGACGAACA 300

GATATAGCCT CTCAGAGTGC AATTTATAAT TGTATGAAGT CGAATTCAAA TATCGATCAG 360

AAACGAGCCG GTATCTATCT CATCGTGTGC TTAGCTGAAA CTCATTCTGG AAATGTTATT 420

CGATATGCGA ATTATCTTCT GAAAATGTTA AATAATGGAA ATGGATTAGA TGAAGATACA 480

GTCAAGATGG CTTCAAAAGC TCTCGCTTTT CTGATTGCGA CTTGTAAATC ATACGCGGCC 540

GAGCTGGTTG ATCGTTGTCT TGATCATTGC CACGAATGGC TTGGTCAAAA TGTTCCACAT 600

AGTCAGCAAC CCAAAAATCA ACAGGAAATT GATCAAATTC GTCGACTCGC CGCTTCACAC 660

CTCTCTCGTG AGCTCGCACT GGCCACACCG ACAGCATTCT TTCTTCGTGT AAACTTATTT 720

TTCAAGTATA TCTTCAACGC TGTCAGAGAC AAGAATCCAG CTGTAAGAAT CGCCGGAATT 780

GATGCATTAC ACGTGGTTTT GACAATTGTT TCACAGCGTG AAGCAAAGAA TAAAACTGAG 840

TGGTTTAAGA AATGTTTCGA TGAAGCACTG GAAGGTCAAC CAAACCCATC GCAAAAGGAC 900

GATTTGGATA GATGGCATGC CGTCGCCCTG ATTCTCAATG AACTTCTTCG AATTTCTGAT 960

CAACGATTCG AACTCATCAG ATGTGAATCC TCACAGTTTA TTAAACAAAA GTTTTTGAAA 1020

GAAGACGAAG AAGAAGGTGT TGAATGGCTT GTCCTAACTA AGCAACAAAC TATTGTGGAA 1080

AGTGTGACTG CTCGAAAGCT GGTTTTGGAA CGATTTCCGA AGATACTCGA TTGTGTTCGT 1140

CAGATAATAC CTCTCGCAAA CAAAACTTCA TCCACGAAAC AGCAAAGCTC GATTTACCTG 1200

AATACAGTTC TCATGCAGCT TCTACCAAGA ATTTGTGCAT TTCCACAATG TGATCGAACT 1260

TTTCAAACAA TCTCATTCGA CACTTCATTT ACTATTCTTC AAAGAAATGC GGTCGCTGCT 1320

CCAGCAATCG GAATGATGAT GCTCTCGAAT CCAGATGTAC ATGCCACACA TATCGAGAAA 1380

ACAATCAGTT TTATCTCTGC TGCTATCAAA AAAACGACGA ATTCTGATGT TCTCGATAAT 1440

TATTTCACAT TCCTGTTCCT ATTTGTGGAT GCTTATCACG AACAAGTGAC GACACAAATC 1500

AAGGCAATAA TTCCACAATT AATGGATATT ACCCTGTCTC GATCGCTGGC AAACGTGCTA 1560

AAAATGATTA TGATGAGAAT TCCGAAACTG CGGCTGAATG TTCAAGATGG TGTTATGGCT 1620

TCTGTCTATC AAACACTCAC TGGATCTCTA ATTCCACCAA AATCCGAACC GATTGGAAGG 1680

CCTGCGAGTC CTAAAGCTAT TTTGCAGAAA GCAGAAACCG ATCCAAAAGA GCTTCAACGA 1740

ATCGTGCTGG CTGTCGATGT GCTCGGTGAA TTCTATTTCT CAAGAGGTGC CTTGCAGAGA 1800

ATCATGCAAT ACGTTGCAGA TTACTACTTG ACAGCGGACA ATGTGGAAAT CCGTTTGGCT 1860

GCTGTCTCTT CGTGTTGTGA AATGGTCGTA CCATTTGTTG GAGTTTATAA AAAAGTTACA 1920

AGTGACAAGA GAAATAGTCT TCTTCAAACT ATTTATGGTG TGCTGCGAGC TGTTTGTTCG 1980

GTTATTGTTA ATGATCAAGA TGTCCGTGTC AGAATGCAAG TAATCAGCTG TTTCGGACAA 2040

ATGCCACGGC CATTCCTTGC TCATTTGGCT CAACCCGAAA TGCTCGAAGT ACAATTTATG 2100

GCTCTTCACG ACGAAAAACT CGAAATGCAG CAAGCATGTG TGACGTTACT CGGACGACTC 2160

GCAGAGCTCA ATCCGGCACT TGTTTTGCCA CGTCTTCGAT TGATGCTCCT AGAGACATTG 2220

AGTCAAATGC AACAAAGTGG TCAGGCAAGA TTGGAGCAAC ATTCTGCGAA AATGATCGCG 2280

CAATTGGCGA AACAGAGTCC AAAGTTCATG AGACCATACG TTGGAAGTTT AATGATTGCT 2340

ATGATTCCAA AATTGAGAAA TGATCAAAAA TATGCCGAAG TGACTGCCCA AGTTCTGAAT 2400

GCTGTCAGCG AAATCGCCGT GATTGGTGGA GCCGAAATAG TAAAAAATTT GAAGCCATTG 2460

TTCGAAAAGT TGACACATAT GATAAATGAT TCGAGCAGCT TGCATAAACG AGAGGCGGCT 2520

CTCCGTGCAA TTGGTGGAAT ATGTCGTTCA ACTGCATATG TTGTGGATCC ATATCGAGAC 2580

TATCCAAGTC TACTTGATGA TCTTCTTCGA ATCCTGAAAA CTGTCATGTC AAATACAATG 2640

AGACGAGAAG CTATCAAAAC TCTCGGAATT CTTGGAGCAA TCGATCCATA TACTCATAAA 2700

GTATTCACTG GCTCAGTACA AAGCTCGACA GCTATAAGCA CAGCCTTATC ACTTCCAATC 2760

TCTGAAACTG ATTCAAAAGA TCCACGTCAA GACATTATTC ATTGGTTTAA CTATGAAAAA 2820

TGTACATTAG AAGAGTTTTA TCCAGCGATT ACGATTGCAA ATTTGATGTT AATGATGCAA 2880

GACGAAGATT CGCAGAGCTA CGCGGAAATT GCTCAAGCTA TAGTAACAAT CTTCAGAAGT 2940

CTTGGTGATA TGGCACCATT GTATACAGAA CAAGTCATTC CAAGGCTAAT AGAAGTTTGT 3000

CGGCGAGCAA CTGAATCATC AAATCGAGCC AATTTGAGAG AGTTCTTTCT TCAACAATTG 3060

GCAAATTTCG TGGCAATTAT AAGAAAGCAC GCGGCACCGT ATATGCCAGC TATTTTCACG 3120

ATTATCGCGG ATGCTTGGAA AGAGGATATA TCCGTCAAAA TGGTGGTCAT TGAAGTTCTC 3180

ACTGATATGG GAACTGCCAT TGGAAACGAT TTCAGTAAAT ACACAGGCGA ACTAATACCG 3240

TATCTGTTGA CTGTACTACA AACTGATAAG ACCAAGGAAC GAGTTCTCAC TGTGAAGGTA 3300

ATGGAATCAA TTCAAAAACT GACTCATTGT ATAGTTCAAC ATCTTCATCT TGTTCTTCCG 3360

CCTCTTCTCA TAATTCTTGA TGATTTCTCG TTGAAGCTAT CAATTCGAAA CACGGCTCTT 3420

TCTACAGTAC TTCATATGAC TCAACAAGTT GATGTGTCTG CATATGCTCC ACGTATGATG 3480

CAGAGTTGGC ATCATAATAT TTCAACTGCT GAAATGAGAG ATAAACTGCT CCTTTTATTG 3540

ATTGAAATCA TCAAGCAACT CGGAAAATTC TTTGATATTT TCAAACGAGG CGTTGATCAG 3600

AAGCTACGCG ATTATAATCT TGATAAAAGT GTTCACTATG AGCAGTATCG GAAGCTTGCT 3660

CAACGAGCAC AAATGTCACG TGATGTGCTT ACTTCATCAG TTTTTGCGGG ATCCAATGGA 3720

AATATACAGT ACTCTTCGAC GCAAGCGGGC ATGCGAGGTC AGGCTAACAA TGTTTATGCA 3780

AATAATGATC TACACGAGAG ACTGATGAAT GGATCAATTG ATTCGGGAGC GAGTCGACAG 3840

GACAATCGAG ATGATTATTA TAGATATGGA GTCGAGGAGA AAATTTCAGA AGAAGTTCCA 3900

AAAGTTGCTC CAACAACTGC TCGCCCTACC AGTGAACTCG TGACGGTTCA AATCACAAAA 3960

CAACGTCTCA ATAAGGATGC TTTGATGCCA CAATGGAAAA ATGAGAATTT GACTTCAAAA 4020

GATGAATGGT TGCAGTGGTT GATGAAGATT CGAATAGGAT TTTTAACTTA TGGAAGTTCT 4080

CCATCGTTAC GTGCAGCTTC TTCACTTGGT GATCAACATC CTCATCTTGC ACGTGATCTA 4140

TTTCCAGCTG CTTTCATGTC TGTATGGACT GAACTTGATT CGGATGTACA AAACGATCTA 4200

ACTTCATGTC TTCTCCGAGC AATCTCCACA GGAATTCCAG AATTAATTCA AACGATTCTG 4260

AATCTTGCCG AGTTTATGGA TCATTCTGAG AAAGGACCAC TTCCAATTTC TCATGATGTT 4320

CTCGGTCGAT GGGCTGAACA AACGAAGGCT TTTGCCAAAG CATGTAGATA TAAGGAGATG 4380

AGTGTACTGA AGAAGTCGGG TTCAATGCAA ACGACGTTTA CGAGAAAAGT GAAGCTGGAG 4440

CCAAATGATT GTCAGAGCCT TATCACATAT GCCAATAAAT TGAACGTACA AGAGGAAGCT 4500

GCAGGTGTCG TAAGATATGC TGAAAGAAAT GAGATGAACT TCCAAATGCG CGGTCGCTGG 4560

TACGAAAAAC TGAACGAATG GGAAAAAGCA CTCGGAGCAT ATGAACTTGA GGAAAAGAAA 4620

AAATCGTCAT GCCCCAATCT CCAGGTTTAT GATGAAAAAG ATCATTTAAT GACACCAGAA 4680

GAAGCAGCAA CAGCAGAAGA AGCTCGAATG CATGAGATGA GATGTTTAGA AGCATTGGGA 4740

AGATGGGATG AATTGAATAG TAAATCAGTA GTTTGGGCGG ATCAACGAGG AAATAGGAAT 4800

GATTCGGTTC GTGATGAGAT CAATAAGAAG CAATTGGATC ATAAAATGGC AGTGATTGCG 4860

GCAAGAGGAG CATGGGCTGT TGACAATTGG GAACGAATGG CTGATTATGT TTCAGTGATA 4920

TCTGAAAATA CACAAGACGG TGCAATGCTT CGAGCTGTGG TAGCTGTTCA CAATGATGAA 4980

AACACAAAAG CCATGGGGCT AATCGAAAAA GTTCGCGAAA TGATTGACAG TGAGCTGACA 5040

GCAATGGCTA ACGAAAGTTA CGAGAGAGCA TATATTCCAA TGGTTTCTGT TCAACAAATG 5100

GCTGAATTGG AAGAAGCTAT TGAATATAAG ACCCGTCCCG AACGTCGACC TCGAATCGCA 5160

CTTCTGTGGA GTCGACGCCT ACAAGGATGT CGGCGAAATG TGGAGCAATG GCAGAGACTT 5220

ATTATGCTCC GTGGACTTGT ATTATCTCCA CAAGAGATGC ATCCACTACG AGTCAAATTT 5280

TCATCAATGT GTCGGAAACA GGGAAAGAAT TCAATGTCTC GTGCAGTACT TCGAGAGCTT 5340

CTCTCTCTTC CAGCAAATTC TGATTTGGTG CGCGCAAAAG CTCCATTTGA CAAGCCGCTG 5400

TTGGTGTTGG CGTTGGCAAA ACAGTTGTAT CAGGATGATC ACAAAGATGA AGCAATTCGA 5460

GCACTTGAAG ATTTGGCGAA TCATTGGAAT AAAAGAATTA ATCCGATTCC AAAGGCGACT 5520

GGTAGAGAAC TGATTCCTCC GTCGACTAAA GAACCCGCGA GAATTTGTGC AAAAGTTTTG 5580

TTGAAACTTG GAGAATGGAC TGAGCTGAAA TCAAAGACTT CGAATAATAT GCAAGTCGGA 5640

GAATTATCAT TTGTTCGTCA ACAAGTATCA CCTCAATATC GAACAAAAGA ATCTCGTACA 5700

CCTGAGACAA TTGCCTTTGA GAATACCATA AATTACTATC AACAGGCAAC ACAATACGAT 5760

CCTGGATGGC ATAAAGTTTG GCACAAATTG GCTTCTACAC ATTTCTATGC TGTCTGTCGA 5820

GAACGACCAC ATCCAACAAC GGTCATTTCA CCGCCGCAGC AGCCTCAACA ACCGAAGAAA 5880

ATGCATATTC CACCAGTTAC GAGGGCAACA TCTCCACCTC CACCGGCTCA AAAGTCGCCT 5940

CAGCCTGCTC CATTTCATAG TATTACAGAG CCACTCTCTG TAATTATAGA TTACCCTGTT 6000

CCACCACCAC TTGGTTCACT CGTCGGTCTT CCACCAATGC CAGCTTATTT GTCTTCGAAT 6060

TCATCACTTC CACCACAACA TCATCATGTC TCACCATTGA GCAACGATTC TCCATCGAAT 6120

TCAGCTGAAA ATAAGCTTTA TTTGAAACAC GCGGCTCACG CTGTGCGATG CTTCGCAAAG 6180

GCTCTGATGT GCTCACCGGG TTCTCGACTT GAAGATACTC TCCGATTGAT GCAATTGTGG 6240

TTTGATCATG GAGATGATAA AGATCAAGAT GTTTATTTTG CTCTTACGGA GACAATCTTT 6300

GATCTTCCTG TGACAACATG GTTAGAAGCT ATTCCTCAAT TGATGGCTCG TTTGGATTGT 6360

CCAGATGATC AGAAAAGTGT TCAACTTGTT CTTCGAGTTC TTTGTGAAAT TGCCAGGCAT 6420

AGACCACAAG CAGTAATCTA TGCACTAACT GTTGCATCGA GAAGTAAGGA TGTACATAGA 6480

AGTAAGAATG CTGGAACAGT TCTCGAAAAA ATGATGGAAT ATCATTCAAA ATTGGTTCGA 6540

GAGGCAAGTC TTGTGACAGA AGAGCTTGTT CGTTGCGCAA TTCTGTGGCA TGAACAGTGG 6600

CATGATGCAC TTGATGATGC GAGCCGTGTG TATTTCCACG ATAACAATGT GCAGGCGATG 6660

TTTGATGCTT TGAGAAATAT GAATGATTTG ATGCAAAAAG GAGCTCCAAC AACCATGAAA 6720

GAGCACAGTT TCCAACAGAC GTATAGTTCC GATTTGAAAG AAGCAGGACG ATATGTACAA 6780

GCATTTGAGA GTAGTGGAAA TGTGAAAGAT CTTAATCAGG CGTGGGAGAT TTATTGTTCG 6840

GTTTTCAAAA AGCTGCGTGA TCAACTTGCC ACTTTGAACT CGTTGGATCT TGTCTACGTA 6900

TCACCTAATT TGGTCAGCGC AAAAGATTTG GAACTCGTTG TTCCTGGTAC ATACGATCCA 6960

TCAGCTCCAA TAGTTTCCAT TCAAAGTTTC AGCTCAAAAA TGAATGTAAT CACTAGCAAG 7020

CAACGTCCTC GTAAAATGGT GATCCGTGGA TCAAATGGTT TAGACTATCA ATTCTTGCTA 7080

AAAGGACATG AAGATCCGAG ACAAGATGAA CGTGTGATGC AACTTTTTGG ACTAGTCAAC 7140

ACACTTCTTG CCAACAATTC TGAGACTTGT CGCCGCAATT TGACTATTCA AAGATACTCG 7200

ATTGTAGCTT TGAGCAAAGA TTCTGGATTG ATTGGTTGGG TTCCAAATTG TGATACACTT 7260

CATACACTTG TCAAGGAATA TCGAGAAAAG AAAGCAAAGA TTCCATTGTC GATTGAGCAC 7320

AAAACACTTC AGAAATTATC ACTTGAAACT GAACATTTGA CTTTAATGCA GAAGCTTCAA 7380

TTATTTGAAA GTGCTCTAAG TGTAACACAA GGAGAAGATC TCCGACATGT ATTATGGTTG 7440

AAGAGTCCGA GTTCTGAAGT TTGGTTTGAT CGACGAACCA ATTATACAAG ATCAGTTGCA 7500

TGTATGTCAA TGGTTGGATA TATTCTTGGT CTCGGTGACA GACATCCATC CAACTTGATG 7560

CTCGATCGAT TGACCGGAAA AGTTGTACAC ATTGATTTCG GTGACTGTTT CGAAGTTGCT 7620

ATGCTCCGTG AAAAATTCCC TGAACGAGTT CCATTCCGAC TTACCAGAAT GCTCATCAAC 7680

GCTATGGAAG TAACTGGATT GGACGGAGTA TACAATTACA CTGCCGAACG TGTCTTGAAA 7740

ATGTTGCGAA CAAATCAAGA ATCATTGTTA GCAGTTTTAG AAGCATTTGT CTATGATCCA 7800

GTAATTAATT GGCGTCTTGT GGAAGGAATG AAAAAGGATC CGAAAACTAG AAAAGATACA 7860

GGTGGACGTC AGAATATGGC TGGTGCTGTA TTACCATCAT CAAGTACAAC TGATTCAATT 7920

ATGGAGACGA TTAAGAGGAA ACTCGATGGG ACCGAATTCG TTCACACTGA CGGATCAACT 7980

CCACCTGAAC CACTTCAAGT AACTGAGCAA CTTGCAATGC TCACAGAGCA AGCAACATCT 8040

CCATTGAATT TGTGTCAAAG TTATATTGGA TGGTGTCCGT TTTGGTAG 8088

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i++f  ++++++skq+p+k+++rGs+g  y++L+kg+eD rqderv+qlf+lvNtlLa++

Q: 2327  IQSFSSKMNVITSKQRPRKMVIRGSNGLDYQFLLKGHEDPRQDERVMQLFGLVNTLLANN  2386

         899*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +et rr+L+i++y++v+ls+ sgli+wv+n+++L+ l+k+++ekka            ++

Q: 2387  SETCRRNLTIQRYSIVALSKDSGLIGWVPNCDTLHTLVKEYREKKAKIPL------SIEH  2440

         ***************************************99887764432......4889

S: 121   stvqarkpklkhlkls..levfkevlenlvpkdllkklllekfpspeewfelrkaytrsl  178

         +t q    +++hl+l+  l+ f+ +l+  +  + l+++l+ k+ps+e+wf++r++ytrs+

Q: 2441  KTLQKLSLETEHLTLMqkLQLFESALSVTQG-EDLRHVLWLKSPSSEVWFDRRTNYTRSV  2499

         999999999999999999********99555.79**************************

S: 179   AvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrniv  238

         A +s+vgyiLgLgdrh++nl++d+ tg+vvhidfg +fe a+ ++k+pe vPFRLTr+++

Q: 2500  ACMSMVGYILGLGDRHPSNLMLDRLTGKVVHIDFGDCFEVAMLREKFPERVPFRLTRMLI  2559

         ************************************************************

S: 239   nalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeeel  297

         na++vtg++Gv++ + e vl++lr ++e+ll++Le+f+ydp+++w+  ++ +k+ ++ +

Q: 2560  NAMEVTGLDGVYNYTAERVLKMLRTNQESLLAVLEAFVYDPVINWRLVEGMKKDPKT-R  2617

         **********************************************94433333322.2

Domain Sequence
(FASTA)

IQSFSSKMNV ITSKQRPRKM VIRGSNGLDY QFLLKGHEDP RQDERVMQLF GLVNTLLANN 60

SETCRRNLTI QRYSIVALSK DSGLIGWVPN CDTLHTLVKE YREKKAKIPL SIEHKTLQKL 120

SLETEHLTLM QKLQLFESAL SVTQGEDLRH VLWLKSPSSE VWFDRRTNYT RSVACMSMVG 180

YILGLGDRHP SNLMLDRLTG KVVHIDFGDC FEVAMLREKF PERVPFRLTR MLINAMEVTG 240

LDGVYNYTAE RVLKMLRTNQ ESLLAVLEAF VYDPVINWRL VEGMKKDPKT R 291

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Translation regulation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0031931	; C:TORC1 complex
GO:0031932	; C:TORC2 complex
GO:0016303	; F:1-phosphatidylinositol-3-kinase activity
GO:0005524	; F:ATP binding
GO:0008144	; F:drug binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000492	; P:box C/D snoRNP assembly
GO:0043053	; P:dauer entry
GO:0008340	; P:determination of adult lifespan
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0008406	; P:gonad development
GO:0040007	; P:growth
GO:0045727	; P:positive regulation of translation
GO:0009408	; P:response to heat
GO:0031929	; P:TOR signaling cascade
GO:0006412	; P:translation

KEGG

cel:CELE_B0261.2

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR024585	; DUF3385_TOR.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR009076	; Rapamycin-bd_dom.
IPR026683	; TOR/Smg1.

Pfam

PF11865	; DUF3385; 1.
PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08771	; Rapamycin_bind; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; FALSE_NEG.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013