EKS-CAE-00317

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00317

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	304.2	1.4E-90	1125	1387	263

Status

Unreviewed

Ensembl Protein

B0414.7a

UniProt Accession

Q960A2;

Protein Name

Protein Synonyms/Alias

Protein MTK-1, isoform b;

Gene Name

mtk-1

Gene Synonyms/Alias

mtk-1; CELE_B0414.7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
B0414.7	B0414.7b	B0414.7b
B0414.7	B0414.7a	B0414.7a

Organism

Caenorhabditis elegans

Functional Description

Protein Length

1418

Protein Sequence
(FASTA)

MSSNQYKRIK RCKSMPTIDD ETVGEAVRKT IMKKVATRMN TSKREYMGRR SLGVATVSTK 60

IKRKKSKTER DRDMYDDMYD DEGYAASPTS SSSCTYRCIP ILERSNRNSQ NYLPSAESSS 120

SDSNDRVISH PNHRPILLYS TALSMAPQQN LSVESLSDAL DELEGADRSK LHMEITQFLK 180

KADGEKSKQI QMSQRLMNCP QFGQTMRLIV EESEHTRYTF ENILWLILKS YFSTTSTGRD 240

VMIGKSEWIA EDEKIVKARK QYMMVMDMIK EFKFEVGKND KDDSPFESLN RRMEFSPDYC 300

ENLRDARKRV SDVLDKYETL VDLFPNQNAL WKVVELDRGE AEKKLLEGRM TSMRVWLNTL 360

DDLTDKFKAL GVLFEIETMP DAEECWFRPL DENNKIFALE DVRAVFLEYV KNSLNLKGMK 420

KVLSRVEKII ELTLVKTAIL MQKPPTSYAA ATASNGPSFP FSQTMKDRYG DMIEWRFCNS 480

TSISLNLPPL NNLFFFLVAV PMQLVVHWLE IRAATEPPDS CLLDELTFDA MITDSRDCVE 540

EAVRIKKNYL TILQSMCSKC AMPGFLYPLK YNTYVLDVFK KYIHYVKCWS NCDSVRKDPP 600

LLFSRLEMEW SSAVQCAKSV KSALELLCTT YCDIVESLIR EVVEVYADDQ IEDIKNRYVY 660

NTDSENEDEE DDEDMITIGS PKKPLVELKA KHRFMLELNS LTREVKEREL RIFSLLRITL 720

NDSHDAVGYE LRSGVDRAQM FHEMVPDFCL IQLTMASDEQ GDVNDDDDHV NLKIVLFVYR 780

TSVDKAYVET CMLAISEGRK IDDGCIVIVP DKDHKLRKHW KGRVVKIVID EETRICYRWL 840

RDDIILCLAN GSIRADMEHK YKNFLKCISP ACSSNFLITS RIQQLTEESL LPHLDEERKR 900

IGILLEKTEI RLEPKEEQSK EKSALSSLGF KLEKHFLVAF QIHRDVAKVV SDSFMDGLGN 960

EMVEKALALT RQWMQYVEVK STIPSPTLPM WASPGFTFLQ YITEPRWSNP EIMTNDQFQE 1020

FNDLVKLFEA KVIKSSSNIG TPGNTGTPMQ RNTRSTSSKT SSSSMENHKR TRKENQMLKL 1080

QELEDKRNRI DYDNLQIGKV ITDDNRRNFV LATDKKITTK APFQWALLDH IASGSFGSVH 1140

RAMDIDSHRV IAAKVMRIQR ENHKAIESEI NIFRQLIHEN LVKYYGVQVE DSDVIIFMEY 1200

CSQGTLERIC HGKMDLKMVR QYTNSLLRAV QYLHSHKIIH RDIKPANIFL DKCTVLKLGD 1260

FGCSSRLVES STVYGEFQTT AGTPQFMAPE IYSYGEKDET TGSYSGYGRS VDIWALGATV 1320

VNMMTGKVPF EGQTRHQIAF ALCFRKQKPT YPDIADKRPD VKRFFDNCFE FLPNDRPTAA 1380

ELLQTTFANV NITDENHIPD YQSQSSKDKS SPSSFFLV 1418

Nucleotide Sequence
(FASTA)

ATGAGTAGTA ATCAATACAA AAGAATCAAA AGATGCAAAA GTATGCCAAC GATTGACGAC 60

GAAACAGTTG GAGAAGCCGT TAGAAAAACA ATAATGAAAA AAGTGGCGAC AAGGATGAAT 120

ACTTCAAAAC GGGAATACAT GGGAAGAAGA AGTCTTGGTG TCGCAACGGT CTCTACGAAA 180

ATTAAACGAA AAAAGAGCAA AACTGAACGA GATCGTGATA TGTACGATGA CATGTATGAC 240

GACGAAGGAT ATGCGGCTTC ACCGACTTCC TCATCTTCTT GCACATATCG ATGCATTCCA 300

ATTCTTGAGA GAAGTAACCG AAATTCTCAG AATTACCTTC CTTCAGCAGA ATCGAGTTCC 360

AGTGATAGTA ATGATCGAGT TATCAGTCAT CCCAATCACC GACCAATTCT TCTCTACAGT 420

ACCGCACTTT CCATGGCTCC TCAACAAAAT CTTTCGGTTG AATCGTTATC AGACGCATTG 480

GATGAGTTGG AAGGTGCGGA TCGAAGCAAA CTTCACATGG AAATCACACA GTTTTTGAAA 540

AAGGCTGATG GTGAAAAGAG CAAACAAATT CAAATGTCAC AGCGGTTGAT GAATTGTCCT 600

CAGTTTGGAC AGACTATGAG ATTGATAGTT GAAGAAAGTG AACATACAAG ATACACATTT 660

GAAAATATTC TTTGGCTCAT TCTAAAATCA TATTTTTCAA CAACCTCTAC AGGTCGTGAT 720

GTGATGATCG GAAAATCGGA ATGGATTGCT GAAGATGAGA AAATTGTTAA AGCTCGAAAA 780

CAATACATGA TGGTTATGGA TATGATTAAG GAATTCAAGT TTGAAGTTGG AAAAAATGAT 840

AAAGATGATT CACCTTTCGA ATCGCTTAAT CGTCGAATGG AATTCAGTCC TGATTACTGT 900

GAAAATCTAC GTGATGCGAG AAAACGAGTC AGTGATGTAC TTGATAAATA TGAGACTCTT 960

GTTGATTTAT TCCCAAATCA AAATGCATTA TGGAAAGTGG TTGAATTGGA TCGAGGAGAG 1020

GCTGAAAAAA AACTTCTTGA AGGAAGAATG ACATCGATGA GAGTTTGGCT CAATACATTA 1080

GATGATTTAA CTGACAAGTT CAAAGCGCTC GGAGTTTTGT TTGAAATTGA AACAATGCCA 1140

GACGCCGAGG AATGTTGGTT CCGCCCACTA GATGAGAATA ACAAAATATT CGCATTAGAA 1200

GACGTTCGTG CCGTATTTCT GGAATACGTT AAAAATAGTC TAAATCTGAA AGGAATGAAG 1260

AAAGTTTTGT CTCGAGTCGA GAAAATAATC GAGCTAACAT TAGTGAAAAC AGCGATTCTG 1320

ATGCAGAAAC CACCAACATC ATATGCAGCT GCAACAGCTT CAAATGGGCC ATCATTTCCT 1380

TTCAGTCAAA CTATGAAAGA TAGATATGGT GATATGATTG AATGGAGATT TTGCAATAGT 1440

ACATCGATTT CTCTCAATCT TCCTCCTCTC AATAATTTAT TCTTCTTTCT CGTCGCAGTT 1500

CCAATGCAAC TGGTTGTTCA TTGGCTTGAA ATTCGTGCAG CCACTGAACC ACCAGACTCT 1560

TGTTTACTTG ATGAGCTCAC ATTCGATGCT ATGATAACAG ATTCTAGAGA TTGTGTGGAA 1620

GAAGCTGTGC GAATTAAAAA GAATTACTTG ACCATTTTGC AATCTATGTG TTCAAAGTGT 1680

GCAATGCCCG GATTTCTGTA TCCACTTAAA TATAATACTT ATGTTTTAGA TGTTTTCAAG 1740

AAATATATAC ATTATGTGAA ATGCTGGTCA AATTGTGATT CTGTTCGAAA AGATCCACCT 1800

CTATTGTTCT CACGATTAGA AATGGAATGG TCGTCAGCTG TCCAATGTGC AAAATCAGTG 1860

AAGTCTGCTC TGGAATTGTT GTGTACAACT TATTGTGACA TCGTAGAATC TCTTATACGA 1920

GAAGTTGTGG AAGTATATGC AGATGATCAA ATTGAAGACA TTAAAAATCG TTACGTGTAT 1980

AATACAGATT CTGAAAATGA AGATGAAGAG GATGATGAAG ATATGATCAC AATCGGATCA 2040

CCTAAGAAAC CATTGGTTGA GTTAAAGGCT AAACATAGGT TCATGCTAGA ATTGAACTCA 2100

TTAACTCGAG AAGTCAAGGA ACGAGAACTT CGGATCTTTT CCCTTCTGAG AATTACTCTC 2160

AACGATAGTC ATGATGCAGT TGGTTACGAG CTTCGTTCAG GAGTCGATCG AGCTCAAATG 2220

TTTCATGAAA TGGTTCCTGA TTTCTGCCTA ATCCAGCTCA CAATGGCTTC AGATGAGCAA 2280

GGCGATGTTA ATGATGACGA TGATCATGTA AATCTAAAGA TCGTGCTTTT CGTCTATCGA 2340

ACATCGGTCG ATAAAGCTTA CGTCGAGACA TGTATGCTGG CAATATCTGA AGGAAGAAAA 2400

ATAGATGATG GATGTATTGT TATTGTACCA GACAAAGATC ACAAACTGAG AAAGCACTGG 2460

AAAGGACGAG TTGTCAAGAT TGTGATTGAC GAGGAGACAA GAATTTGTTA TAGGTGGCTG 2520

CGTGATGATA TTATTTTGTG TTTGGCAAAT GGAAGTATCC GCGCAGACAT GGAACATAAA 2580

TACAAAAACT TCTTAAAATG CATTTCACCG GCGTGCTCGT CAAACTTCTT GATCACATCC 2640

AGAATTCAAC AACTTACGGA AGAATCATTG CTACCACATT TGGACGAAGA AAGGAAGAGA 2700

ATTGGGATTT TGCTTGAAAA AACCGAAATT CGATTAGAGC CAAAAGAAGA ACAGTCAAAA 2760

GAAAAAAGTG CTCTCTCCAG TTTGGGATTC AAACTCGAAA AACATTTTCT CGTTGCTTTT 2820

CAAATTCACC GTGACGTGGC AAAAGTAGTC AGCGACTCGT TTATGGATGG ACTTGGAAAT 2880

GAAATGGTCG AGAAAGCATT GGCTTTGACA AGGCAATGGA TGCAATATGT TGAAGTTAAA 2940

AGTACTATTC CATCACCAAC TCTTCCGATG TGGGCATCAC CTGGATTCAC ATTTCTTCAA 3000

TACATCACTG AACCAAGATG GAGTAATCCA GAGATTATGA CTAATGATCA ATTCCAAGAA 3060

TTTAATGATC TTGTCAAATT ATTTGAAGCA AAGGTCATAA AGTCATCATC CAACATAGGA 3120

ACTCCAGGCA ACACAGGAAC ACCAATGCAA AGAAACACAC GATCGACAAG TTCAAAAACG 3180

TCATCATCAT CGATGGAAAA TCACAAAAGA ACTAGAAAAG AGAATCAAAT GTTGAAATTA 3240

CAAGAACTTG AAGATAAGAG AAATAGAATT GATTACGACA ACCTGCAAAT CGGGAAAGTT 3300

ATTACAGACG ATAACAGAAG AAACTTTGTT CTTGCCACAG ACAAAAAGAT TACTACAAAA 3360

GCTCCATTTC AATGGGCACT TCTTGATCAT ATTGCATCTG GAAGCTTTGG TTCTGTACAT 3420

CGTGCAATGG ATATTGATTC TCATCGTGTC ATTGCAGCAA AAGTCATGCG AATTCAACGC 3480

GAAAACCATA AAGCAATCGA ATCGGAAATC AACATTTTCC GTCAATTAAT TCATGAGAAT 3540

CTTGTCAAAT ATTATGGTGT TCAAGTTGAA GACAGTGACG TCATCATATT CATGGAATAT 3600

TGCTCACAGG GTACACTTGA ACGAATTTGT CACGGAAAAA TGGATTTGAA AATGGTTCGA 3660

CAATATACGA ATAGCTTGTT GCGGGCTGTA CAGTATCTTC ACTCTCATAA AATCATTCAT 3720

CGTGATATAA AGCCAGCGAA CATATTCCTC GATAAGTGTA CCGTACTCAA ATTAGGAGAT 3780

TTCGGATGTT CTTCGCGACT TGTCGAGTCA AGTACAGTAT ACGGAGAGTT TCAAACAACT 3840

GCCGGAACTC CTCAATTCAT GGCACCAGAA ATTTATTCAT ATGGGGAAAA GGATGAAACA 3900

ACTGGAAGCT ATAGTGGTTA CGGTAGAAGT GTTGACATTT GGGCACTTGG AGCTACCGTA 3960

GTCAATATGA TGACTGGAAA AGTTCCATTC GAAGGACAAA CTCGTCATCA AATAGCCTTC 4020

GCGCTTTGCT TCCGCAAGCA AAAACCAACT TATCCTGATA TTGCCGACAA AAGACCAGAT 4080

GTTAAACGAT TCTTCGATAA TTGCTTTGAA TTTCTTCCAA ATGATCGGCC TACAGCTGCG 4140

GAACTTCTTC AAACTACGTT TGCAAATGTT AATATAACGG ACGAAAATCA TATCCCGGAC 4200

TATCAATCAC AATCTTCAAA GGACAAATCG TCACCAAGCT CGTTTTTTCT AGTCTAG 4257

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekkevkalkeEikllkelkH  60

         w+  ++i++Gsfgsv++a+d+d+++++a K ++i++e+      +ka+++Ei+++++l H

Q: 1125  WALLDHIASGSFGSVHRAMDIDSHRVIAAKVMRIQREN------HKAIESEINIFRQLIH  1178

         666789****************************7774......579*************

S: 61    enivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHek  120

         en+vkyyGv+ve++++ if+Ey+++G+l+++  ++gk++ +++++yt+++l++++yLH++

Q: 1179  ENLVKYYGVQVEDSDVIIFMEYCSQGTLERI--CHGKMDLKMVRQYTNSLLRAVQYLHSH  1236

         *******************************..78*************************

S: 121   kivHRDiKgaNilldssgvvklsDFGaskrlaelntkaaelesltGtlaymaPEvikkke  180

         ki+HRDiK+aNi+ld+++v+kl+DFG+s+rl e++t+++e+++++Gt+++maPE+++ +e

Q: 1237  KIIHRDIKPANIFLDKCTVLKLGDFGCSSRLVESSTVYGEFQTTAGTPQFMAPEIYSYGE  1296

         *********************************************************977

S: 181   k........gygrkaDiWslgcvviemltgkrPfaeldeelaimfkvgakktkPeipek.  231

         k        gygr++DiW+lg++v++m+tgk Pf e +++++i f+++++k+kP++p+

Q: 1297  KdettgsysGYGRSVDIWALGATVVNMMTGKVPF-EGQTRHQIAFALCFRKQKPTYPDIa  1355

         77999*****************************.566*******************986

S: 232   .lseegkdflekcleldpkkrpsaeeLLkhef  262

           ++++k+f+++c+e  p++rp+a+eLL+++f

Q: 1356  dKRPDVKRFFDNCFEFLPNDRPTAAELLQTTF  1387

         67899************************998

Domain Sequence
(FASTA)

WALLDHIASG SFGSVHRAMD IDSHRVIAAK VMRIQRENHK AIESEINIFR QLIHENLVKY 60

YGVQVEDSDV IIFMEYCSQG TLERICHGKM DLKMVRQYTN SLLRAVQYLH SHKIIHRDIK 120

PANIFLDKCT VLKLGDFGCS SRLVESSTVY GEFQTTAGTP QFMAPEIYSY GEKDETTGSY 180

SGYGRSVDIW ALGATVVNMM TGKVPFEGQT RHQIAFALCF RKQKPTYPDI ADKRPDVKRF 240

FDNCFEFLPN DRPTAAELLQ TTF 263

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0016246	; P:RNA interference

KEGG

cel:CELE_B0414.7

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013