EKS-CAE-00386

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00386

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	401.1	3.9E-120	28	323	296

Status

Reviewed

Ensembl Protein

B0478.1b.1

UniProt Accession

Q8WQG9; Q17507; Q9UAH2;

Protein Name

Stress-activated protein kinase jnk-1

Protein Synonyms/Alias

Gene Name

jnk-1

Gene Synonyms/Alias

jnk-1; B0478.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
B0478.1	B0478.1a	B0478.1a
B0478.1	B0478.1b.1	B0478.1b.1
B0478.1	B0478.1b.2	B0478.1b.2

Organism

Caenorhabditis elegans

Functional Description

Responds to activation by environmental stress byphosphorylating a number of transcription factors, and thus regulates transcriptional activity (By similarity). May coordinate locomotion by acting via type-D GABAergic motor neurons and regulate synaptic vesicle transport in conjunction with unc-16.

Protein Length

372

Protein Sequence
(FASTA)

MEPSSIHVPE NYYSVTIGEA QMVVLKRYQN LRLIGSGAQG IVCSAFDTVR NEQVAIKKLS 60

RPFQNVTHAK RAYRELKLMS LVNHKNIIGI LNCFTPQKKL DEFNDLYIVM ELMDANLCQV 120

IQMDLDHERL SYLLYQMLCG IRHLHSAGII HRDLKPSNIV VRSDCTLKIL DFGLARTAIE 180

AFMMTPYVVT RYYRAPEVIL GMGYKENVDV WSIGCIFGEL IRGRVLFPGG DHIDQWTRII 240

EQLGTPDRSF LERLQPTVRN YVENRPRYQA TPFEVLFSDN MFPMTADSSR LTGAQARDLL 300

SRMLVIDPER RISVDDALRH PYVNVWFDEI EVYAPPPLPY DHNMDVEQNV DSWREHIFRE 360

LTDYARTHDI YS 372

Nucleotide Sequence
(FASTA)

ATGGAACCAT CCTCTATTCA TGTTCCCGAA AACTATTATT CGGTGACAAT AGGGGAAGCG 60

CAGATGGTTG TTCTCAAACG ATATCAAAAT CTCAGGTTGA TCGGGTCTGG TGCTCAGGGA 120

ATTGTTTGCT CAGCGTTTGA TACGGTACGG AACGAACAAG TTGCCATAAA GAAATTATCA 180

AGGCCATTTC AAAATGTGAC ACATGCAAAG AGGGCTTATC GAGAATTAAA ACTCATGAGT 240

CTTGTAAATC ATAAAAATAT CATAGGTATT CTGAATTGTT TTACACCACA AAAGAAACTC 300

GACGAATTCA ACGATCTTTA TATTGTTATG GAACTTATGG ATGCAAATCT TTGTCAAGTG 360

ATTCAAATGG ATTTGGATCA TGAGAGATTA TCATATCTTC TTTATCAAAT GTTATGTGGT 420

ATCAGGCATT TACATAGTGC TGGAATTATA CACAGGGATT TGAAACCATC AAACATTGTC 480

GTTCGAAGTG ATTGTACTCT AAAAATCTTG GATTTCGGAT TGGCTCGAAC TGCGATTGAG 540

GCATTCATGA TGACTCCTTA CGTTGTGACA AGATACTATC GGGCACCGGA AGTTATTTTA 600

GGAATGGGTT ACAAGGAAAA TGTTGATGTT TGGTCAATTG GGTGTATATT TGGAGAGCTG 660

ATACGTGGAC GTGTACTATT CCCGGGTGGT GACCATATCG ATCAGTGGAC TAGGATTATT 720

GAACAATTGG GTACTCCGGA TAGGTCATTT TTAGAACGGT TACAACCAAC TGTCAGAAAT 780

TATGTGGAAA ATCGGCCAAG ATATCAAGCA ACGCCGTTTG AAGTTCTCTT CAGTGATAAC 840

ATGTTCCCAA TGACAGCTGA CAGCTCAAGA CTTACAGGTG CTCAAGCTCG TGACTTACTT 900

TCTCGAATGT TAGTCATAGA TCCGGAAAGA AGGATTTCTG TGGATGATGC ACTGAGACAT 960

CCATATGTCA ATGTTTGGTT TGATGAAATT GAAGTATATG CTCCACCTCC ACTTCCGTAT 1020

GATCATAATA TGGATGTGGA ACAGAACGTG GATTCATGGA GAGAGCACAT TTTCCGAGAG 1080

CTCACAGATT ACGCAAGAAC CCATGACATT TATTCCTGA 1119

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++l+ +g+Ga+g+v+sa+d+ ++e+vaikklsrpfq+ t+akr++RElkl++ ++h+Ni

Q: 28    YQNLRLIGSGAQGIVCSAFDTVRNEQVAIKKLSRPFQNVTHAKRAYRELKLMSLVNHKNI  87

         899*********************************************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i +l++ftp+++l+e++d+Y+v+elm+++L++vi+++ l++e++++llyq+l+g+++lHs

Q: 88    IGILNCFTPQKKLDEFNDLYIVMELMDANLCQVIQMD-LDHERLSYLLYQMLCGIRHLHS  146

         ************************************9.**********************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslke  180

         a++iHrDlKPsN++v +dc+lkildFGlar+a +  +  +t+yv+tr+YraPe++l  +

Q: 147   AGIIHRDLKPSNIVVRSDCTLKILDFGLARTAIEAFM--MTPYVVTRYYRAPEVILG-MG  203

         *******************************999976..*****************9.99

S: 181   ytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearnyi  240

         y+++vD+Ws+GCI++El++g++lfpg d+idq+++i+e+lgtp+++fl++++  ++rny+

Q: 204   YKENVDVWSIGCIFGELIRGRVLFPGGDHIDQWTRIIEQLGTPDRSFLERLQP-TVRNYV  262

         *****************************************************.5*****

S: 241   kslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehpY  288

         +++p++++++fe lf++            +  +a+dLl+++Lv+dp++Risv++aL+hpY

Q: 263   ENRPRYQATPFEVLFSDnmfpmtadssrlTGAQARDLLSRMLVIDPERRISVDDALRHPY  322

         ****************99*********9999*****************************

S: 289   l  289

Q: 323   V  323

Domain Sequence
(FASTA)

YQNLRLIGSG AQGIVCSAFD TVRNEQVAIK KLSRPFQNVT HAKRAYRELK LMSLVNHKNI 60

IGILNCFTPQ KKLDEFNDLY IVMELMDANL CQVIQMDLDH ERLSYLLYQM LCGIRHLHSA 120

GIIHRDLKPS NIVVRSDCTL KILDFGLART AIEAFMMTPY VVTRYYRAPE VILGMGYKEN 180

VDVWSIGCIF GELIRGRVLF PGGDHIDQWT RIIEQLGTPD RSFLERLQPT VRNYVENRPR 240

YQATPFEVLF SDNMFPMTAD SSRLTGAQAR DLLSRMLVID PERRISVDDA LRHPYV 296

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0005737	; C:cytoplasm
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004705	; F:JUN kinase activity
GO:0008340	; P:determination of adult lifespan
GO:0006972	; P:hyperosmotic response
GO:0009408	; P:response to heat
GO:0030050	; P:vesicle transport along actin filament

KEGG

cel:CELE_B0478.1

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008351	; MAPK_JNK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01772

; JNKMAPKINASE.

Created Date

20-Feb-2013