EKS-CAE-00045

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00045

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	360.9	6.7E-108	356	647	292

Status

Reviewed

Ensembl Protein

B0495.2

UniProt Accession

Q09437;

Protein Name

Putative serine/threonine-protein kinase B0495.2

Protein Synonyms/Alias

Gene Name

B0495.2

Gene Synonyms/Alias

B0495.2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
B0495.2	B0495.2	B0495.2

Organism

Caenorhabditis elegans

Functional Description

Protein Length

719

Protein Sequence
(FASTA)

MSDHLGSSHD EGELSDESHK KSQRASSSDE PNPAKSNKGL ESKMRESILS RLSKRKNSES 60

DDDTTEQRFS IQPKNAQKAK EDRYRDKERD KKREKDKRDD RRDVRGPDAR QKDRDFKGRQ 120

ERSGRDQKVH EHRHHHHHRK HETDGHRTNR SNRDRSSERD SEKHKRHIDR HKKSSTTSPD 180

NDKSPHKKSK HTDVPADAKL FDRILDPNYK KKDDDVLVIE DVEMSPIEIL EEKEEKEIVE 240

FTIDSPAGPK KYSKFESDPE SDHDDTKPKS PGKAEDDDDV IEVLDDALHS DDDADSDEDK 300

YLKTPEDREW EEMTETEQRL HKEAMKKRAS MKQKTLIAQL PVFYPGLMGC RNIDEYECVN 360

RVDEGTFGVV YRGKDKRTDE IVALKRLKME KEKEGFPITA LREINMLLKA GNHPNIVNVK 420

EILLGSNMDK IYMAMEFVEH DMKSLLDTMS RRNKRFSIGE QKTLLQQLLS GIEHMHKLWI 480

LHRDLKTSNL LMSHKGILKI ADFGLAREYG DPLKKFTSIV VTLWYRSPEL LLGTRLYSTP 540

VDMWSVGCIM AEFILLKPLF PGRGELEQIK KIFMEMGTPT ESIWPGVTEL DGWKALTFEK 600

YPYNQLRKRF LAGRLLNDTG FKLLNGLLTL DPKNRFSATQ ALDHEWFTEE PYPVPPEEFP 660

TFPAKSEQNK APPPAKQKQQ ENRISHVDPE TAKLLKQFEV RPEQVKPGGF SLKFDPTRF 719

Nucleotide Sequence
(FASTA)

ATGAGCGACC ACTTGGGAAG TTCTCATGAC GAAGGTGAGC TGTCAGATGA AAGTCACAAG 60

AAAAGTCAAA GAGCGTCGAG TTCCGATGAG CCAAATCCAG CCAAGTCGAA CAAAGGTTTG 120

GAATCAAAAA TGCGTGAAAG CATATTAAGT CGTCTGAGCA AGCGGAAGAA CAGTGAAAGC 180

GATGATGATA CCACAGAACA ACGGTTTTCA ATACAGCCTA AAAACGCTCA AAAGGCAAAA 240

GAGGACCGAT ATCGAGATAA AGAAAGAGAT AAAAAACGGG AAAAGGACAA ACGAGATGAC 300

AGAAGAGACG TGCGTGGACC AGATGCTCGA CAAAAAGATC GTGATTTCAA AGGACGACAG 360

GAAAGATCTG GAAGAGATCA GAAAGTACAT GAACATAGAC ATCATCACCA TCATAGAAAA 420

CACGAAACAG ATGGGCACCG CACAAACAGA AGTAACAGAG ATCGTTCGTC TGAAAGAGAC 480

TCAGAAAAAC ACAAAAGGCA TATTGATCGT CATAAAAAAT CCAGCACAAC TTCTCCTGAT 540

AATGACAAAT CGCCACACAA AAAGTCAAAA CATACAGATG TTCCAGCAGA TGCAAAGCTC 600

TTTGATAGAA TTCTCGACCC GAACTACAAA AAGAAAGATG ACGATGTTCT CGTGATTGAA 660

GATGTAGAAA TGTCGCCAAT TGAGATATTA GAAGAAAAGG AAGAGAAAGA AATTGTCGAA 720

TTCACTATAG ACTCACCAGC TGGCCCCAAG AAATACTCAA AATTCGAAAG CGACCCAGAA 780

AGTGATCATG ACGATACTAA ACCGAAGAGC CCTGGAAAAG CTGAAGACGA TGACGATGTC 840

ATAGAAGTAT TGGATGATGC TCTACATTCG GATGATGATG CAGATAGCGA TGAAGATAAA 900

TATTTAAAAA CACCAGAAGA TCGAGAATGG GAAGAAATGA CTGAAACTGA ACAAAGACTT 960

CATAAAGAAG CAATGAAAAA ACGTGCGTCA ATGAAACAAA AAACATTGAT CGCCCAGTTA 1020

CCTGTTTTTT ATCCCGGTCT CATGGGATGT AGAAATATTG ATGAATATGA ATGTGTGAAT 1080

CGAGTTGATG AAGGAACATT TGGAGTTGTA TATCGTGGAA AAGATAAACG AACGGATGAG 1140

ATTGTCGCGT TAAAAAGACT GAAAATGGAG AAAGAGAAAG AAGGATTTCC AATCACTGCT 1200

CTTCGTGAAA TCAATATGCT TCTAAAAGCT GGAAATCACC CGAATATTGT GAATGTTAAA 1260

GAAATTCTAC TAGGAAGTAA TATGGATAAG ATCTACATGG CTATGGAGTT TGTTGAACAT 1320

GACATGAAAA GTCTTTTAGA CACAATGTCT CGTCGAAACA AACGATTTTC GATAGGTGAA 1380

CAGAAAACAC TTCTGCAGCA ACTGCTATCT GGAATTGAAC ACATGCATAA ACTTTGGATT 1440

CTGCATCGTG ATCTCAAAAC ATCCAATTTA TTGATGTCTC ACAAGGGAAT TCTGAAAATT 1500

GCCGATTTTG GACTTGCTCG TGAATATGGA GATCCACTGA AAAAGTTTAC ATCAATTGTT 1560

GTAACTCTCT GGTATCGATC ACCGGAATTG CTTCTTGGTA CACGTCTCTA TTCAACTCCC 1620

GTTGATATGT GGTCTGTTGG ATGTATTATG GCAGAGTTTA TTCTCTTAAA ACCATTGTTC 1680

CCGGGACGCG GTGAACTTGA ACAAATTAAG AAAATTTTCA TGGAAATGGG AACTCCCACG 1740

GAATCAATAT GGCCTGGAGT CACTGAACTC GACGGTTGGA AGGCATTGAC ATTTGAGAAG 1800

TATCCATATA ATCAATTGAG AAAGAGGTTC CTAGCTGGAA GACTTCTCAA TGACACTGGT 1860

TTTAAGTTAC TTAATGGCCT ACTCACTCTG GACCCAAAGA ATCGATTCTC CGCTACACAA 1920

GCTCTTGATC ACGAATGGTT CACTGAAGAA CCTTATCCAG TGCCACCGGA GGAGTTTCCA 1980

ACGTTTCCCG CTAAAAGCGA ACAGAATAAA GCTCCACCGC CGGCGAAGCA GAAACAACAA 2040

GAAAATCGCA TTTCTCATGT GGATCCAGAA ACTGCCAAGC TCCTAAAACA ATTCGAGGTG 2100

CGACCAGAGC AAGTGAAACC CGGTGGATTC TCATTGAAGT TCGATCCAAC AAGATTCTGA 2160

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkel.khkn  59

         ye+++++ eGt+g+vy++kdk+t+e+vAlK++++ekekeg+pitalrEi++l +  +h+n

Q: 356   YECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGFPITALREINMLLKAgNHPN  415

         899**********************************************9987766****

S: 60    ivkLlevva.kdkkklyLvfefleqdLkkllkkkkkk..klsleevkslllqlleglayl  116

         iv+++e++  ++ +k+y+ +ef+e+d+k+ll++++++  ++s  e k+ll+qll+g++++

Q: 416   IVNVKEILLgSNMDKIYMAMEFVEHDMKSLLDTMSRRnkRFSIGEQKTLLQQLLSGIEHM  475

         ********95666*******************99888779********************

S: 117   HsnkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgak  176

         H+ +ilHRDlK++NlL+s++g+lk+aDfGlar+++ plk++t+ vvTlwYr+PelLlg++

Q: 476   HKLWILHRDLKTSNLLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLLGTR  535

         ************************************************************

S: 177   eYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeyk.  235

          Yst vD+Wsvgci+ae++  kplf+g+ e +q+++if  +gtp+e++wp+v++l  +k

Q: 536   LYSTPVDMWSVGCIMAEFILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKa  595

         ***********************************************************9

S: 236   ksfpkkkkkklkekv...kklkekaldllekllaldpkkRisakealqhkyf  284

          +f+k+++++l++++   + l++++++ll+ ll+ldpk+R+sa++al+h++f

Q: 596   LTFEKYPYNQLRKRFlagRLLNDTGFKLLNGLLTLDPKNRFSATQALDHEWF  647

         9**************774456677***************************9

Domain Sequence
(FASTA)

YECVNRVDEG TFGVVYRGKD KRTDEIVALK RLKMEKEKEG FPITALREIN MLLKAGNHPN 60

IVNVKEILLG SNMDKIYMAM EFVEHDMKSL LDTMSRRNKR FSIGEQKTLL QQLLSGIEHM 120

HKLWILHRDL KTSNLLMSHK GILKIADFGL AREYGDPLKK FTSIVVTLWY RSPELLLGTR 180

LYSTPVDMWS VGCIMAEFIL LKPLFPGRGE LEQIKKIFME MGTPTESIWP GVTELDGWKA 240

LTFEKYPYNQ LRKRFLAGRL LNDTGFKLLN GLLTLDPKNR FSATQALDHE WF 292

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0040010	; P:positive regulation of growth rate
GO:0000003	; P:reproduction
GO:0006974	; P:response to DNA damage stimulus

KEGG

cel:CELE_B0495.2

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013