EKS-CAE-00133

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00133

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	421.3	2.5E-126	238	497	260

Status

Reviewed

Ensembl Protein

B0545.1b.1

UniProt Accession

P34722;

Protein Name

Protein kinase C-like 1

Protein Synonyms/Alias

PKC; Tetradecanoyl phorbol acetate-resistant protein 1;

Gene Name

tpa-1

Gene Synonyms/Alias

tpa-1; B0545.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
B0545.1	B0545.1b.2	B0545.1b.2
B0545.1	B0545.1b.1	B0545.1b.1
B0545.1	B0545.1a	B0545.1a

Organism

Caenorhabditis elegans

Functional Description

PKC is activated by diacylglycerol which in turnphosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.

Protein Length

567

Protein Sequence
(FASTA)

MTSRSNSGPG IQRRRGAIKH ARVHEIRGHQ FVATFFRQPH FCSLCSDFMW GLNKQGYQCQ 60

LCSAAVHKKC HEKVIMQCPG SAKNTKETMA LKERFKVDIP HRFKTYNFKS PTFCDHCGSM 120

LYGLFKQGLR CEVCNVACHH KCERLMSNLC GVNQKQLSEM YHEIKRGTHA TASCPPNIAN 180

LHLNGETSKN NGSLPNKLKN LFKSHQYSVE EQKETDEYMD NIWGGGDGPV KKFALPHFNL 240

LKVLGKGSFG KVMLVELKGK NEFYAMKCLK KDVILEDDDT ECTYIERRVL ILASQCPFLC 300

QLFCSFQTNE YLFFVMEYLN GGDLMHHIQQ IKKFDEARTR FYACEIVVAL QFLHTNNIIY 360

RDLKLDNVLL DCDGHIKLAD FGMAKTEMNR ENGMASTFCG TPDYISPEII KGQLYNEAVD 420

FWSFGVLMYE MLVGQSPFHG EGEDELFDSI LNERPYFPKT ISKEAAKCLS ALFDRNPNTR 480

LGMPECPDGP IRQHCFFRGV DWKRFENRQV PPPFKPNIKS NSDASNFDDD FTNEKAALTP 540

VHDKNLLASI DPEAFLNFSY TNPHFSK 567

Nucleotide Sequence
(FASTA)

ATGACATCCA GAAGCAACTC CGGTCCCGGA ATTCAACGTC GTAGAGGAGC GATAAAACAT 60

GCGCGAGTAC ACGAGATTCG CGGCCATCAG TTCGTCGCCA CCTTCTTCCG ACAACCCCAT 120

TTCTGTTCGT TGTGCTCCGA TTTCATGTGG GGGCTCAACA AACAGGGATA TCAGTGTCAG 180

TTGTGCTCGG CCGCCGTGCA CAAAAAATGC CACGAGAAAG TGATTATGCA GTGCCCGGGA 240

AGTGCAAAGA ATACAAAGGA GACTATGGCT CTCAAAGAAC GATTTAAAGT GGACATACCG 300

CATCGATTCA AGACGTATAA CTTCAAAAGT CCCACGTTTT GTGATCACTG TGGTTCAATG 360

CTTTACGGAC TTTTTAAACA AGGACTACGG TGTGAAGTAT GCAACGTGGC GTGTCATCAC 420

AAATGCGAGC GGCTCATGTC AAACCTGTGT GGTGTAAATC AAAAGCAACT CAGCGAGATG 480

TACCATGAAA TTAAACGTGG CACCCACGCC ACAGCAAGCT GTCCGCCCAA CATTGCCAAC 540

CTTCATTTGA ACGGAGAGAC GAGTAAGAAC AATGGAAGTC TGCCGAACAA GTTGAAGAAT 600

CTATTCAAGT CACACCAGTA TAGTGTAGAA GAACAAAAGG AGACCGACGA GTATATGGAT 660

AATATTTGGG GCGGTGGAGA TGGCCCTGTC AAAAAATTCG CCCTACCTCA TTTCAATTTG 720

CTCAAAGTGC TTGGAAAAGG ATCGTTTGGA AAGGTTATGC TGGTGGAATT GAAAGGAAAA 780

AATGAGTTTT ATGCAATGAA ATGTCTGAAA AAGGACGTGA TATTGGAGGA TGATGATACG 840

GAATGTACTT ATATTGAACG ACGAGTGCTC ATTTTGGCGA GCCAGTGCCC GTTCTTGTGT 900

CAATTGTTTT GCTCGTTCCA GACTAATGAA TACCTCTTCT TCGTAATGGA ATACTTAAAT 960

GGTGGTGATC TGATGCACCA TATTCAACAA ATCAAAAAAT TTGATGAAGC CCGGACACGC 1020

TTTTATGCAT GTGAAATTGT GGTGGCTCTG CAGTTTTTGC ACACTAATAA TATTATCTAT 1080

CGTGATCTCA AGCTTGATAA TGTGCTGTTA GACTGTGATG GTCACATAAA GCTTGCCGAT 1140

TTTGGTATGG CAAAAACCGA GATGAATCGA GAAAACGGAA TGGCTAGCAC ATTCTGTGGA 1200

ACACCGGATT ATATCAGTCC TGAAATTATC AAGGGTCAAC TTTACAATGA AGCTGTCGAT 1260

TTTTGGTCAT TTGGAGTTTT GATGTATGAA ATGCTCGTCG GACAATCACC GTTCCATGGA 1320

GAAGGAGAAG ATGAATTATT TGATTCAATT CTTAATGAGA GGCCATATTT CCCGAAAACT 1380

ATATCGAAGG AAGCAGCGAA ATGTCTATCA GCCTTATTCG ATAGAAATCC GAATACCCGG 1440

CTAGGAATGC CTGAATGCCC TGATGGTCCA ATCAGGCAAC ATTGCTTCTT CCGAGGTGTC 1500

GACTGGAAAC GGTTTGAAAA TCGACAGGTT CCGCCACCGT TTAAGCCGAA CATTAAATCC 1560

AACTCGGACG CCTCGAACTT CGACGACGAC TTCACGAACG AGAAGGCGGC GTTGACACCT 1620

GTGCACGACA AGAACCTACT GGCTTCAATC GATCCTGAAG CATTCCTTAA CTTCTCTTAT 1680

ACGAATCCTC ACTTCTCAAA ATAG 1704

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f+llkvlGkGsfgkv+l+elk+++e+ya+k+lkkdv+l+ddd e+t++e+rvl las++p

Q: 238   FNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCP  297

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+qlf++fqt++ lffv+ey+nGGdlm+hiq+++k++e+r+rfya+ei++al+flh+++

Q: 298   FLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACEIVVALQFLHTNN  357

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeei.legkttstfcGtPdyiaPeilkeeeygk  179

         iiyrdlkldnvlld++GhikladfG++k+e+  e+ ++stfcGtPdyi+Pei+k++ y++

Q: 358   IIYRDLKLDNVLLDCDGHIKLADFGMAKTEMnRENGMASTFCGTPDYISPEIIKGQLYNE  417

         *******************************4456799**********************

S: 180   svdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdp  239

         +vd+w++Gvl+yeml+gqsPf+ge edelf+sil++++++Pk++skea+++l++l++++p

Q: 418   AVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAAKCLSALFDRNP  477

         ************************************************************

S: 240   ekrlGvkeegeedikehaff  259

         ++rlG+ e  +  i++h+ff

Q: 478   NTRLGMPECPDGPIRQHCFF  497

         ******8877889******9

Domain Sequence
(FASTA)

FNLLKVLGKG SFGKVMLVEL KGKNEFYAMK CLKKDVILED DDTECTYIER RVLILASQCP 60

FLCQLFCSFQ TNEYLFFVME YLNGGDLMHH IQQIKKFDEA RTRFYACEIV VALQFLHTNN 120

IIYRDLKLDN VLLDCDGHIK LADFGMAKTE MNRENGMAST FCGTPDYISP EIIKGQLYNE 180

AVDFWSFGVL MYEMLVGQSP FHGEGEDELF DSILNERPYF PKTISKEAAK CLSALFDRNP 240

NTRLGMPECP DGPIRQHCFF 260

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0008340	; P:determination of adult lifespan
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0035556	; P:intracellular signal transduction
GO:0000003	; P:reproduction

KEGG

cel:CELE_B0545.1

;

InterPros

IPR000961	; AGC-kinase_C.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013