EKS-CAE-00379

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00379

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	489.5	3.1E-147	16	276	261

Status

Reviewed

Ensembl Protein

C03C10.1.1

UniProt Accession

P42168;

Protein Name

Casein kinase I isoform alpha

Protein Synonyms/Alias

CKI-alpha; CK1;

Gene Name

kin-19

Gene Synonyms/Alias

kin-19; C03C10.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
C03C10.1	C03C10.1.3	C03C10.1.3
C03C10.1	C03C10.1.2	C03C10.1.2
C03C10.1	C03C10.1.1	C03C10.1.1

Organism

Caenorhabditis elegans

Functional Description

Protein Length

341

Protein Sequence
(FASTA)

MAGVMSVKDF IVATKYKLIR KIGSGSFGDI YVSINVTNGE EVAIKLESNR ARHPQLLYES 60

KVYRILQGGV GIPHIRWYGT EREYNVLVMD LLGPSLEDLF NFCSRRFTMK TVLMLADQMI 120

GRIEYVHVKN FIHRDIKPDN FLMGIGRHCN KLFLIDFGLA KKYRDSRTRT HIPYREDKNL 180

TGTARYASIN AHLGIEQSRR DDMESLGYVL MYFNRGTLPW QGLKAATKKQ KYEKISEKKM 240

TTSVEHLCKG FPAEFPMYLS YTRGLRFDES PDYMYLRQLF RILFRTLNHQ YDYTFDWTML 300

KQKAQQSQSS GVPGTNTTTQ GATVPSAGVP AGVAPGGTTP Q 341

Nucleotide Sequence
(FASTA)

ATGGCAGGTG TGATGTCAGT TAAGGACTTC ATCGTTGCGA CAAAATACAA GCTCATACGA 60

AAAATCGGAT CAGGATCATT CGGTGACATT TATGTATCGA TCAACGTGAC GAACGGCGAG 120

GAGGTGGCCA TTAAGCTGGA AAGCAATCGG GCGAGGCACC CGCAGTTGCT GTACGAGTCC 180

AAAGTGTATC GTATCCTACA GGGAGGAGTC GGAATTCCAC ATATCAGATG GTACGGAACC 240

GAGCGAGAGT ACAATGTGCT TGTCATGGAT CTTCTCGGTC CTTCATTGGA AGATCTCTTC 300

AATTTCTGCT CCAGAAGATT TACCATGAAG ACTGTTCTCA TGCTGGCTGA CCAGATGATC 360

GGACGTATCG AATATGTGCA TGTCAAGAAC TTTATTCATC GTGACATAAA GCCAGACAAC 420

TTCTTGATGG GAATAGGACG TCACTGCAAC AAGCTCTTCT TGATCGACTT CGGATTGGCC 480

AAAAAATACC GTGATTCACG CACCAGAACT CATATTCCAT ACAGAGAGGA CAAGAACTTG 540

ACCGGTACCG CCAGATACGC ATCCATCAAC GCCCACTTGG GAATTGAGCA GTCGAGAAGA 600

GATGACATGG AATCCCTTGG ATACGTTTTG ATGTACTTCA ACCGTGGAAC TCTTCCATGG 660

CAAGGATTGA AGGCCGCCAC GAAAAAGCAA AAGTATGAGA AGATTTCTGA GAAGAAAATG 720

ACGACATCAG TCGAGCACTT GTGCAAAGGA TTCCCAGCTG AGTTCCCAAT GTACTTGAGC 780

TACACAAGAG GACTTCGTTT CGATGAATCT CCAGATTACA TGTACTTGCG GCAACTGTTC 840

AGAATTCTCT TCAGAACGCT CAATCATCAG TACGACTACA CATTCGACTG GACAATGCTC 900

AAACAAAAGG CTCAACAATC GCAATCCAGT GGCGTCCCCG GAACCAACAC TACTACACAG 960

GGAGCTACCG TTCCATCAGC TGGAGTTCCA GCTGGAGTTG CACCAGGAGG AACTACTCCA 1020

CAGTAA 1026

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60

         y++++kiGsGsfGdiy ++n+++geevaikles+++++pql +es+vy+ilqggvgiP++

Q: 16    YKLIRKIGSGSFGDIYVSINVTNGEEVAIKLESNRARHPQLLYESKVYRILQGGVGIPHI  75

         89**********************************************************

S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120

         r++g+e++ynvlv+dllGpsledlf++c+r+f++ktvl+ladq+i rieyvh k++i+rd

Q: 76    RWYGTEREYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMIGRIEYVHVKNFIHRD  135

         ************************************************************

S: 121   ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk  180

         ikPdnfl+gigr+++k++lidfGlakkyrd++t++hipyre+k+ltGtaryasin+hlg+

Q: 136   IKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRTHIPYREDKNLTGTARYASINAHLGI  195

         ************************************************************

S: 181   eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef  240

         eqsrrdd+eslgyvl+yf+rg+lPWqglkaatkkqkyekisekk++ts+e+lc+gfP+ef

Q: 196   EQSRRDDMESLGYVLMYFNRGTLPWQGLKAATKKQKYEKISEKKMTTSVEHLCKGFPAEF  255

         ************************************************************

S: 241   atylkyvrklkfeekPdyeyl  261

          +yl+y+r l+f+e+Pdy+yl

Q: 256   PMYLSYTRGLRFDESPDYMYL  276

         *******************97

Domain Sequence
(FASTA)

YKLIRKIGSG SFGDIYVSIN VTNGEEVAIK LESNRARHPQ LLYESKVYRI LQGGVGIPHI 60

RWYGTEREYN VLVMDLLGPS LEDLFNFCSR RFTMKTVLML ADQMIGRIEY VHVKNFIHRD 120

IKPDNFLMGI GRHCNKLFLI DFGLAKKYRD SRTRTHIPYR EDKNLTGTAR YASINAHLGI 180

EQSRRDDMES LGYVLMYFNR GTLPWQGLKA ATKKQKYEKI SEKKMTTSVE HLCKGFPAEF 240

PMYLSYTRGL RFDESPDYMY L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006915	; P:apoptotic process
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0007052	; P:mitotic spindle organization
GO:0000003	; P:reproduction
GO:0060069	; P:Wnt receptor signaling pathway, regulating spindle positioning

KEGG

cel:CELE_C03C10.1

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013