EKS-CAE-00268

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00268

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	284.0	1.7E-84	34	294	261

Status

Unreviewed

Ensembl Protein

C04A11.3

UniProt Accession

O17566;

Protein Name

Protein Synonyms/Alias

Protein GCK-4;

Gene Name

gck-4

Gene Synonyms/Alias

gck-4; CELE_C04A11.3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
C04A11.3	C04A11.3	C04A11.3

Organism

Caenorhabditis elegans

Functional Description

Protein Length

1228

Protein Sequence
(FASTA)

MAFLNKVKNL FRANQAEKKL PSYIYDNVNP RDHWNIIGEL GDGAFGKVEK AVSRTDPKLF 60

AASKSIEIQE GEELEDFLVE IEILSECKGH PVMLGLYSTY FFENKLTMLL EFCGGGAVDN 120

IIVELGHVLK EDQIRYIGYY VCDALKWLHS QNVIHRDLKA GNILLTQDGQ VRLADFGVSA 180

KLKSEREKRD TFIGTPYWMA PEVMACETFK DQPYDCISDI WSFGITLIEM AQGEPPHSDV 240

SVMRVIIKVQ KSEPPTLLQP SHWTRSFSDI LTRCLVKDPR NRPPAAEIFK HQWFQNAPSK 300

RKMIMDLLAE MYADVQEEVV IDGDEESVAG SDEISQRRGD SWSSASDSPR PATSDGFKVP 360

IVSVPIIETP PPDTPHKKRA APPPPQEVNA HRQSPVVNGK PAENSSFAEF SFSNSNTSSE 420

GTAEFSTPST NKSSAQLSTP AVLSLNTSGS PSSANEFVSP RREALSILDE LTTTLDDEQG 480

STFFNSPRSS ASPRQSPRRS PHESPRHSPR NSPQKEQLFE HSIRDTIMAS RSRPSLSPQL 540

RQLSPSESAS SFDESVNLSF HKLEPAEHAG YVMAHQQMEK TTAQLNERAN AVSNIRTQME 600

EKIADSSNSK QRPISQPITE IPEGIVAQKK VSREEAEAVQ HSNALFKKPS QDMSASLTVR 660

DMAQQKTELR VSSASTPTKT RASPPKRAES NQSVRTSGSS NSVVQHSASS STDYVPTSVS 720

AVPEYFDGPR RNGEQKVPPP EPPVDYEGNA KENAAPSPVP VPKISQKPVP TPSTSTDVQK 780

TNSNVAPRPL GGRKDGNRQT ITKKTRTYMI DGVQVTSTTV HVLGVKDDKV QRKQQLHDLR 840

RLQRDEARQK QELQAEGIKL VEEQARKFTS EQTNLTRTSE LEMDAMERRQ RKEIEDTEGA 900

QEHELRNAQK RLRIEQEKDM RAFKERLKQE MKIFKQELTM LSKVQRKDAL KQRKEQIEIE 960

HQLKEKDFLM QLQQNAEAML QRMAEKHKER MASIEKQFLM QKHNLLRAKE NNIWELEDKQ 1020

MREKFVLHRK LFKDEYYLLR TQMLARHQRE MAQIEKIHQE EEDDLIRALT LDRKKLPKML 1080

RSETKTRSVM FKESLRISAV NMSNAEMQER IRRFDEQEAL RMRAALEDHD LKSQKKLQIL 1140

KERHQEAIIE LDEMQNEKRK QLLEKERNTM KEHEAKYHEM RELWQENLIA RKTVLEEKFE 1200

DELSKQEVFY GMSYTSSQAS TLSGRHMP 1228

Nucleotide Sequence
(FASTA)

ATGGCGTTTT TGAATAAAGT CAAAAACTTG TTTCGTGCCA ATCAAGCGGA GAAGAAGTTA 60

CCTAGTTACA TTTATGACAA TGTGAACCCA CGCGATCACT GGAACATTAT TGGAGAGCTT 120

GGCGATGGAG CATTTGGAAA AGTTGAAAAA GCAGTGTCAC GGACGGATCC CAAACTTTTT 180

GCCGCATCAA AGTCTATTGA AATTCAAGAA GGCGAAGAAC TGGAAGATTT CCTTGTTGAA 240

ATCGAAATTC TCAGCGAATG CAAGGGTCAT CCTGTTATGT TAGGACTCTA TTCTACTTAT 300

TTTTTTGAAA ATAAACTGAC GATGCTTCTC GAGTTTTGTG GAGGTGGTGC TGTTGACAAC 360

ATCATTGTCG AGCTGGGACA TGTACTCAAG GAAGATCAAA TCCGATACAT CGGATACTAC 420

GTGTGTGATG CACTCAAGTG GCTACACTCC CAGAATGTGA TTCACCGTGA TCTGAAAGCT 480

GGCAACATTT TGCTCACCCA AGACGGTCAG GTTCGACTTG CCGATTTTGG AGTTTCGGCG 540

AAGTTGAAGA GTGAACGTGA AAAGAGAGAC ACATTTATTG GCACACCGTA TTGGATGGCT 600

CCGGAAGTTA TGGCTTGCGA GACTTTCAAG GATCAGCCAT ACGATTGTAT TTCGGATATC 660

TGGTCTTTTG GAATCACACT CATTGAAATG GCCCAAGGAG AGCCCCCGCA TTCAGACGTT 720

TCTGTTATGA GAGTTATTAT CAAAGTGCAG AAATCAGAGC CGCCAACGCT TCTCCAACCA 780

TCTCACTGGA CCCGGTCCTT CAGTGACATT CTCACACGAT GCCTTGTCAA GGATCCCAGA 840

AATCGTCCAC CGGCAGCTGA AATCTTCAAA CATCAGTGGT TCCAAAATGC TCCATCAAAA 900

CGAAAAATGA TTATGGATCT ACTCGCCGAA ATGTACGCAG ATGTTCAAGA AGAAGTTGTC 960

ATTGATGGTG ATGAGGAATC AGTGGCAGGA TCCGATGAGA TTTCTCAACG TCGTGGTGAT 1020

AGCTGGAGTT CGGCTTCTGA TAGCCCTCGA CCGGCTACTA GTGATGGGTT CAAAGTTCCC 1080

ATTGTATCGG TACCCATCAT TGAGACACCT CCACCAGATA CTCCTCACAA AAAGAGAGCT 1140

GCTCCGCCAC CACCACAAGA AGTCAATGCT CATCGGCAGT CGCCAGTAGT GAATGGGAAA 1200

CCAGCAGAGA ATTCGAGTTT TGCAGAGTTC TCCTTCTCTA ACAGCAACAC ATCATCAGAA 1260

GGAACTGCCG AGTTCTCCAC ACCATCTACC AACAAGAGTA GTGCGCAACT CTCCACGCCA 1320

GCAGTTCTTA GCCTCAATAC CAGCGGCAGT CCTTCATCTG CCAACGAGTT TGTCAGTCCA 1380

CGCAGAGAAG CGCTCAGTAT TCTCGATGAG CTTACCACCA CATTGGACGA CGAGCAAGGA 1440

TCAACATTTT TCAACTCACC ACGTTCAAGT GCGTCGCCCC GTCAATCTCC ACGTCGATCA 1500

CCACACGAAT CTCCGCGCCA TTCTCCACGC AATTCCCCAC AAAAGGAGCA ATTGTTTGAG 1560

CATTCGATTC GTGACACGAT AATGGCTAGC CGTAGCAGAC CATCGCTAAG TCCACAGTTG 1620

AGACAACTCT CACCTTCGGA GTCAGCATCT TCTTTCGACG AAAGTGTTAA TTTATCCTTC 1680

CACAAGTTGG AGCCCGCGGA GCATGCTGGA TACGTGATGG CACATCAGCA AATGGAAAAG 1740

ACTACAGCTC AGTTGAACGA ACGTGCAAAT GCTGTGAGCA ATATTAGAAC TCAAATGGAA 1800

GAGAAAATTG CTGACAGCTC TAATTCGAAG CAACGACCAA TCAGTCAACC AATCACGGAA 1860

ATTCCAGAAG GAATTGTTGC CCAGAAAAAA GTCAGCAGAG AGGAAGCGGA GGCGGTTCAA 1920

CACTCAAATG CACTCTTTAA GAAACCATCT CAAGATATGT CAGCCAGTTT GACAGTACGG 1980

GACATGGCTC AACAAAAGAC GGAACTTAGA GTGTCATCAG CCTCAACTCC AACAAAAACT 2040

AGAGCTTCTC CTCCAAAACG CGCCGAATCA AATCAATCTG TGAGGACGAG TGGTTCATCA 2100

AACTCTGTTG TTCAACACTC TGCATCATCA TCGACAGATT ATGTCCCAAC ATCAGTGTCC 2160

GCCGTGCCAG AATACTTTGA TGGACCAAGA CGCAATGGCG AGCAGAAAGT CCCACCACCC 2220

GAGCCGCCAG TAGACTATGA AGGAAATGCT AAAGAGAATG CAGCTCCTTC GCCTGTGCCA 2280

GTTCCTAAAA TCTCCCAAAA ACCTGTACCA ACTCCGTCAA CATCTACAGA TGTTCAGAAG 2340

ACAAACTCAA ACGTTGCTCC GAGACCGCTT GGCGGGAGAA AAGATGGAAA TCGGCAGACA 2400

ATTACTAAAA AGACTAGGAC GTATATGATT GATGGTGTTC AAGTCACATC TACCACAGTT 2460

CATGTGTTGG GTGTTAAGGA TGATAAAGTA CAAAGAAAGC AACAACTCCA CGATCTGAGA 2520

CGCCTTCAAC GTGACGAAGC CCGTCAAAAG CAAGAACTCC AGGCCGAGGG AATCAAGCTT 2580

GTCGAAGAGC AAGCCAGAAA GTTCACATCG GAGCAAACAA ACTTGACACG AACATCGGAA 2640

CTAGAGATGG ATGCTATGGA ACGCCGTCAA CGAAAAGAGA TTGAAGACAC TGAAGGTGCC 2700

CAGGAGCATG AACTACGAAA TGCGCAAAAG CGTCTCCGAA TCGAACAGGA GAAGGATATG 2760

CGAGCGTTCA AAGAGCGTCT GAAGCAAGAA ATGAAGATAT TTAAGCAAGA GTTGACGATG 2820

CTCTCAAAGG TTCAGAGAAA AGATGCGTTG AAGCAACGGA AGGAGCAAAT TGAGATTGAG 2880

CATCAACTCA AGGAGAAGGA CTTTTTGATG CAACTTCAAC AGAATGCGGA GGCAATGCTT 2940

CAACGAATGG CTGAAAAGCA TAAGGAAAGA ATGGCATCTA TTGAAAAGCA GTTCCTGATG 3000

CAGAAGCACA ATTTGCTCCG AGCAAAAGAA AATAACATTT GGGAGTTGGA AGATAAGCAA 3060

ATGAGAGAGA AATTTGTACT TCATCGAAAA CTATTCAAGG ATGAATACTA CCTTCTCCGC 3120

ACACAAATGC TTGCTAGACA CCAACGTGAA ATGGCTCAAA TCGAGAAGAT TCATCAAGAA 3180

GAGGAAGACG ATCTCATCAG AGCACTAACA CTCGATCGTA AAAAGCTACC GAAAATGTTG 3240

CGCTCTGAGA CGAAAACTCG TAGTGTGATG TTCAAAGAGA GCCTGCGAAT CAGTGCAGTG 3300

AACATGTCAA ACGCGGAAAT GCAAGAACGA ATTCGACGAT TCGATGAGCA AGAAGCGTTG 3360

CGCATGAGAG CTGCATTGGA AGATCACGAT TTGAAGTCGC AGAAGAAGTT GCAAATATTA 3420

AAGGAGCGCC ACCAGGAAGC GATCATCGAG CTTGATGAGA TGCAGAACGA GAAGCGCAAG 3480

CAGTTGCTGG AAAAAGAAAG GAACACGATG AAGGAGCACG AGGCAAAGTA TCACGAGATG 3540

CGTGAGCTGT GGCAGGAGAA TTTGATTGCA AGGAAAACGG TGCTCGAGGA GAAGTTTGAG 3600

GACGAACTCT CAAAGCAGGA AGTGTTCTAC GGAATGTCGT ACACTTCGTC TCAGGCCTCA 3660

ACGCTGTCTG GCCGTCACAT GCCTTGA 3687

Domain Profile

S: 1     yelleeigkGalgkvylarek.ktgelvaikkinlekqekleelqkeisvlkklkh.pni  58

         ++++ e+g+Ga+gkv +a ++ + + ++a k i++++ e+le++  ei++l+++k  p +

Q: 34    WNIIGELGDGAFGKVEKAVSRtDPKLFAASKSIEIQEGEELEDFLVEIEILSECKGhPVM  93

         678899************998345667889************************955999

S: 59    veylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskk  118

           ++++++ e++l +++e++ gG++++++  el + lkE+qi+yi   v++aL++lHs++

Q: 94    LGLYSTYFFENKLTMLLEFCGGGAVDNIIV-ELGHVLKEDQIRYIGYYVCDALKWLHSQN  152

         *****************************9.9****************************

S: 119   viHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe...ek  175

         viHrd+ka+niLlt++g+V+L+dfgv+a+l+++r+kr+t++gtpywmAPEv+a+e   ++

Q: 153   VIHRDLKAGNILLTQDGQVRLADFGVSAKLKSEREKRDTFIGTPYWMAPEVMACEtfkDQ  212

         *******************************************************9999*

S: 176   gYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefve  235

          Yd+ +Diws+GIt+ie+a+gepP++d++ +++++k++k+epp+l ++++++++f+++++

Q: 213   PYDCISDIWSFGITLIEMAQGEPPHSDVSVMRVIIKVQKSEPPTLLQPSHWTRSFSDILT  272

         ************************************************************

S: 236   kclqknpekRpsasellkhkFl  257

         +cl k+p++Rp a+e++kh+++

Q: 273   RCLVKDPRNRPPAAEIFKHQWF  294

         ********************97

Domain Sequence
(FASTA)

WNIIGELGDG AFGKVEKAVS RTDPKLFAAS KSIEIQEGEE LEDFLVEIEI LSECKGHPVM 60

LGLYSTYFFE NKLTMLLEFC GGGAVDNIIV ELGHVLKEDQ IRYIGYYVCD ALKWLHSQNV 120

IHRDLKAGNI LLTQDGQVRL ADFGVSAKLK SEREKRDTFI GTPYWMAPEV MACETFKDQP 180

YDCISDIWSF GITLIEMAQG EPPHSDVSVM RVIIKVQKSE PPTLLQPSHW TRSFSDILTR 240

CLVKDPRNRP PAAEIFKHQW F 261

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0010171	; P:body morphogenesis
GO:0040007	; P:growth
GO:0040011	; P:locomotion
GO:0002119	; P:nematode larval development
GO:0040010	; P:positive regulation of growth rate

KEGG

cel:CELE_C04A11.3

;

InterPros

IPR011009	; Kinase-like_dom.
IPR022165	; PKK.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF12474	; PKK; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013