EKS-CAE-00245

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00245

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	312.7	3.5E-93	155	441	287

Status

Reviewed

Ensembl Protein

C05D2.1c

UniProt Accession

P50488; O45139;

Protein Name

Cell surface receptor daf-4

Protein Synonyms/Alias

Abnormal dauer formation protein 4;

Gene Name

daf-4

Gene Synonyms/Alias

daf-4; C05D2.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
C05D2.1	C05D2.1d	C05D2.1d
C05D2.1	C05D2.1c	C05D2.1c
C05D2.1	C05D2.1a	C05D2.1a

Organism

Caenorhabditis elegans

Functional Description

Involved in TGF-beta pathway. May be a receptor for daf-7. Controls the dauer/nondauer developmental decision in a range of environmental conditions. Regulates body size and male tail patterning.

Protein Length

592

Protein Sequence
(FASTA)

MPYQHADSMN CENESSCRQG RSFRGGIGMC CCSTNNCNMP DLIEMVNPSL KKDSDNSALL 60

WASTPSNMDL ESLDKFPFYW IIIIALSVIL CIALLILAYV GWKFQQNKKE EIKKQQKIKF 120

DMEKTDALEA GNVPLVEPEE EMIEMVETPK ELPITDFQLI SKGRFGKVFK AQYTPDSGEK 180

RLVAVKKLNE FQKASFLAEK RIFDELNEYP KWYKSIVEFV CAEKIGDEYW IVTEFHERLS 240

LYELLKNNVI SITSANRIIM SMIDGLQFLH DDRPYFFGHP KKPIIHRDIK SKNILVKSDM 300

TTCIADFGLA RIYSYDIEQS DLLGQVGTKR YMSPEMLEGA TEFTPTAFKA MDVYSMGLVM 360

WEVISRTKLH QTDEPPNYQM PFQVIGFDPT IGLMRNYVVS KKERPQWRDE IIKHEYMSLL 420

KKVTEEMWDP EACARITAGC AFARVWNHIM SSPDSSEGYH SGSSMKNRGV DDVEQSEKPE 480

GIEEMQHYHA SSPSKRQHPS PNPFFDSCPP PPPIPVILEN GGILQPDNAE PEPEELPDLP 540

IVEKIYDIAT NMLFSREELD LMNAQRQVEY EAGADTRAST PTPSGTFGTF TT 592

Nucleotide Sequence
(FASTA)

ATGCCGTATC AGCACGCGGA CTCGATGAAC TGCGAGAACG AAAGCTCCTG TCGCCAAGGA 60

CGATCATTTC GCGGCGGAAT TGGAATGTGC TGCTGTTCGA CCAACAATTG CAACATGCCG 120

GATCTCATCG AGATGGTCAA CCCGTCATTG AAGAAGGATT CGGATAATTC TGCACTTCTG 180

TGGGCTTCAA CTCCATCCAA CATGGATTTG GAATCTCTAG ACAAGTTCCC ATTCTACTGG 240

ATCATCATAA TCGCACTGTC AGTGATCCTT TGTATTGCAC TCTTGATCTT GGCATACGTT 300

GGTTGGAAAT TTCAGCAGAA TAAGAAGGAG GAGATAAAAA AGCAGCAGAA AATTAAATTT 360

GACATGGAAA AAACTGACGC ACTGGAAGCT GGAAATGTGC CTCTCGTGGA GCCGGAAGAG 420

GAAATGATTG AAATGGTGGA GACACCAAAG GAGCTGCCGA TCACTGATTT TCAGTTAATC 480

TCAAAGGGAC GTTTTGGAAA AGTTTTCAAG GCGCAATACA CCCCAGACAG TGGTGAGAAA 540

CGATTGGTTG CGGTGAAGAA ATTGAACGAA TTCCAAAAAG CGAGCTTTTT GGCGGAGAAA 600

AGAATCTTTG ATGAGCTTAA CGAGTACCCG AAGTGGTATA AAAGTATCGT CGAATTTGTG 660

TGCGCCGAGA AAATTGGTGA TGAGTATTGG ATTGTGACCG AATTTCATGA GCGACTTAGT 720

CTCTATGAGT TACTCAAGAA TAATGTAATT AGTATTACAT CTGCCAATCG AATTATTATG 780

TCAATGATCG ATGGGCTTCA ATTCTTGCAT GACGACAGGC CGTACTTCTT TGGACACCCA 840

AAGAAGCCAA TTATTCACAG AGATATCAAG TCGAAGAACA TTCTTGTGAA AAGCGACATG 900

ACCACATGCA TCGCGGACTT TGGCCTCGCC CGAATCTACA GCTATGACAT TGAGCAAAGC 960

GATTTGCTGG GTCAAGTGGG AACGAAACGC TACATGTCAC CAGAGATGCT CGAAGGAGCA 1020

ACCGAATTCA CGCCAACTGC TTTCAAAGCG ATGGACGTTT ATTCGATGGG ACTCGTCATG 1080

TGGGAAGTCA TATCCCGTAC CAAGTTGCAC CAAACCGACG AGCCACCAAA CTACCAAATG 1140

CCGTTTCAAG TCATCGGATT TGATCCCACA ATTGGTCTCA TGAGAAATTA TGTGGTGAGC 1200

AAGAAGGAAC GACCACAATG GAGAGATGAG ATTATTAAAC ATGAATATAT GAGTCTGCTA 1260

AAAAAGGTTA CGGAAGAGAT GTGGGATCCC GAAGCGTGTG CACGGATTAC AGCTGGATGT 1320

GCGTTCGCGA GGGTATGGAA TCATATTATG AGCTCACCGG ACAGTTCGGA GGGGTATCAC 1380

AGTGGAAGTA GTATGAAGAA TCGGGGTGTT GATGATGTTG AACAAAGTGA GAAGCCGGAG 1440

GGTATCGAAG AAATGCAACA TTATCATGCG TCGTCACCCA GCAAGAGACA ACATCCTAGT 1500

CCGAATCCGT TTTTTGATTC GTGTCCACCA CCTCCGCCGA TTCCTGTGAT CCTTGAAAAT 1560

GGAGGAATCC TCCAACCAGA CAACGCGGAG CCAGAGCCCG AAGAGCTGCC GGATCTCCCG 1620

ATAGTCGAGA AAATCTACGA TATTGCGACG AACATGCTAT TCTCAAGAGA AGAGCTTGAC 1680

CTTATGAATG CTCAACGGCA AGTTGAATAC GAAGCTGGGG CAGACACTCG AGCGTCGACA 1740

CCAACGCCTT CAGGGACGTT TGGAACGTTT ACAACATAA 1779

Domain Profile

S: 2     klleligkGrygeVwkaklrg.....eevAvKifstedeaswkrEkeiyqtvllr...he  53

         + ++li+kGr+g+V+ka+++      + vAvK +++ ++as+ +Ek+i+++ +     ++

Q: 155   TDFQLISKGRFGKVFKAQYTPdsgekRLVAVKKLNEFQKASFLAEKRIFDELNEYpkwYK  214

         67899**************987777789**********************999877779*

S: 54    nilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLH  113

         +i++f++a+k       e+++vte+he+ sL++ Lk+++++++++ r+++s+++Gl++LH

Q: 215   SIVEFVCAEKIG----DEYWIVTEFHERLSLYELLKNNVISITSANRIIMSMIDGLQFLH  270

         *********966....48******************************************

S: 114   eeivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGt  173

         ++ ++  g+ K+ i+HRD+kskNilvk+d+t+ciaD+GLa  ++ + e++d     qvGt

Q: 271   DDRPYFFGHPKKPIIHRDIKSKNILVKSDMTTCIADFGLARIYSYDIEQSD--LLGQVGT  328

         ************************************************988..59*****

S: 174   kRYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRcee.vdeeveeyklpfeevvg  232

         kRYm+PE+le+a++++ + afk++DvYs+gLv+WEv+sR++  +++e ++y++pf +v+g

Q: 329   KRYMSPEMLEGATEFTPT-AFKAMDVYSMGLVMWEVISRTKLhQTDEPPNYQMPF-QVIG  386

         ****************95.**********************98999*********.8***

S: 233   sdPsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrv  287

          dP++  m+++vv+kk+rP++++++ k+e+++ l+k+ ee Wd ++ aR ta +

Q: 387   FDPTIGLMRNYVVSKKERPQWRDEIIKHEYMSLLKKVTEEMWDPEACARITAGCA  441

         ****************************************************986

Domain Sequence
(FASTA)

TDFQLISKGR FGKVFKAQYT PDSGEKRLVA VKKLNEFQKA SFLAEKRIFD ELNEYPKWYK 60

SIVEFVCAEK IGDEYWIVTE FHERLSLYEL LKNNVISITS ANRIIMSMID GLQFLHDDRP 120

YFFGHPKKPI IHRDIKSKNI LVKSDMTTCI ADFGLARIYS YDIEQSDLLG QVGTKRYMSP 180

EMLEGATEFT PTAFKAMDVY SMGLVMWEVI SRTKLHQTDE PPNYQMPFQV IGFDPTIGLM 240

RNYVVSKKER PQWRDEIIKH EYMSLLKKVT EEMWDPEACA RITAGCA 287

Keyword

ATP-binding; Complete proteome; Developmental protein; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004675	; F:transmembrane receptor protein serine/threonine kinase activity
GO:0030509	; P:BMP signaling pathway
GO:0040024	; P:dauer larval development
GO:0050832	; P:defense response to fungus
GO:0045087	; P:innate immune response
GO:0030514	; P:negative regulation of BMP signaling pathway
GO:0018991	; P:oviposition
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0040018	; P:positive regulation of multicellular organism growth
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter

KEGG

cel:CELE_C05D2.1

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013