EKS-CAE-00127

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00127

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	553.6	1.2E-166	584	861	278

Status

Reviewed

Ensembl Protein

C07A9.3c

UniProt Accession

P34314; P34323; Q6SSJ1; Q8I4N0;

Protein Name

Serine/threonine-protein kinase tousled-like 1

Protein Synonyms/Alias

Tousled-like kinase 1;

Gene Name

tlk-1

Gene Synonyms/Alias

tlk-1; C07A9.3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
C07A9.3	C07A9.3c	C07A9.3c
C07A9.3	C07A9.3d	C07A9.3d
C07A9.3	C07A9.3a	C07A9.3a
C07A9.3	C07A9.3b	C07A9.3b

Organism

Caenorhabditis elegans

Functional Description

Essential for appropriate transcription during embryonicdevelopment. May act during transcription elongation to activate the RNA polymerase II large subunit (ama-1) by phosphorylating the Ser-2 residues of the C-terminal domain 7-residue repeats. Does not phosphorylate histone H3.

Protein Length

893

Protein Sequence
(FASTA)

MATGDTGRVG NVTYMSSGML GATQFMPQNS SHPSTSVMMQ QVPPQNGGAT RSSPTEMQQC 60

MQAMSEDSIE MRDYNSGVHH MHPHQMQMQQ QQQHHQQQYN MSYHNHQQQM QQMHYHQQQQ 120

QYQQQQAQHH QMYAPQIQQQ QQQPQQQSQQ QSAQQPQQSS AALQHVNESS NLSSAGSISD 180

REPEQHGGTP QRPTAPQSST ATDKKTRKRR KAGPTEDQAT PKQERKITEF MKVGGEVASG 240

NSVARCLLTE YHQNQGSPKR QPAVQQNGSN SYDSQQQQPQ MNQHEMQNSY WGVATPSLGV 300

NNRGTPTPTQ QQHYSSDSNS NSNQSPPGQG NQSGRMVRTI DEETQTDSSL SQANPQNADE 360

VAKMNRIIED HRRQIEELNS KNSLERRKNE ASKETIKRLL IDKNQIERKA LRDKTAADSP 420

RIGCFKTTRT GDSFRDQWVD GWAFAEMDKK TEQINAERNE IASASALLKK RKPLGIGKEP 480

KRPQAVNSQN DSNGMQPSTS SNTNGDDAIF RRPEEPKEIQ YQEYIELDEI YKLRREHLRK 540

EETDLSMEKE RLEKEKQHHV RELKRASNES ASQFNDHRLL HKRYLMLNLL GKGGFSEVWK 600

AFDIEENRYV ACKIHHVNKD WKEEKKANYV KHAMREKDIH KSLDHCRIVK QYDLLTIDNH 660

SFCTVLEYVP GNDLDFYLKQ NRSISEKEAR SIIMQVVSAL VYLNEKSTPI IHYDLKPANI 720

LLESGNTSGA IKITDFGLSK IMEGESDDHD LGIELTSQFA GTYWYLPPET FIVPPPKITC 780

KVDVWSIGVI FYQCIYGKKP FGNDLTQQKI LEYNTIINAR EVSFPSKPQV SSAAQDFIRR 840

CLQYRKEDRA DVFELAKHEL FRPRGAIRAS VAGSVSSPSI PRSPSVNRED DNM 893

Nucleotide Sequence
(FASTA)

ATGGCTACCG GTGATACGGG TCGTGTTGGA AACGTGACCT ATATGAGTTC CGGAATGCTC 60

GGTGCAACAC AGTTTATGCC ACAAAATTCA AGTCATCCAT CAACGTCTGT AATGATGCAA 120

CAGGTACCAC CACAAAACGG TGGTGCAACA CGTTCATCAC CAACTGAGAT GCAACAGTGT 180

ATGCAGGCAA TGTCAGAAGA CTCGATAGAA ATGCGGGATT ATAATTCTGG AGTTCATCAT 240

ATGCATCCTC ATCAAATGCA AATGCAACAG CAGCAGCAAC ATCATCAGCA GCAATACAAT 300

ATGTCGTATC ATAATCATCA ACAACAAATG CAGCAGATGC ATTACCACCA GCAGCAACAG 360

CAATATCAGC AGCAGCAGGC TCAACATCAT CAGATGTATG CTCCACAAAT TCAGCAACAG 420

CAACAGCAGC CCCAGCAACA GTCACAACAA CAGTCTGCCC AACAGCCCCA ACAGTCATCG 480

GCTGCGTTAC AACATGTGAA TGAGTCGAGC AATCTCTCGT CGGCTGGTAG TATTTCGGAT 540

CGTGAACCAG AGCAACACGG TGGTACCCCT CAACGACCGA CAGCGCCACA GTCGTCGACA 600

GCCACTGACA AGAAAACCAG AAAGCGACGA AAAGCTGGTC CAACTGAAGA TCAGGCAACT 660

CCGAAACAAG AAAGGAAAAT CACAGAATTC ATGAAAGTTG GAGGAGAGGT TGCAAGTGGA 720

AATAGTGTTG CACGATGTCT ATTGACGGAA TATCATCAAA ATCAAGGATC ACCGAAGAGG 780

CAGCCAGCTG TACAGCAGAA TGGATCTAAC AGTTACGATT CACAGCAGCA GCAACCACAA 840

ATGAATCAGC ATGAAATGCA AAACTCATAT TGGGGAGTTG CTACACCGTC ATTGGGTGTT 900

AATAATCGTG GAACCCCGAC TCCAACTCAA CAACAACATT ATTCATCGGA TTCAAACTCA 960

AACTCGAATC AATCACCACC TGGTCAGGGA AATCAATCAG GAAGGATGGT GAGAACAATC 1020

GATGAAGAGA CTCAGACGGA TTCTTCGCTA TCTCAGGCTA ATCCTCAAAA TGCTGATGAA 1080

GTCGCCAAAA TGAATAGAAT CATTGAAGAC CATCGTCGCC AAATCGAAGA GTTGAACTCG 1140

AAGAATAGTT TGGAACGAAG AAAGAATGAA GCTTCGAAAG AAACAATCAA GCGATTACTT 1200

ATCGATAAGA ATCAGATCGA ACGAAAAGCC CTTCGCGACA AAACGGCTGC CGATTCACCT 1260

CGAATTGGAT GTTTCAAAAC TACTCGAACT GGTGATTCAT TCCGTGATCA ATGGGTTGAT 1320

GGGTGGGCGT TTGCCGAAAT GGATAAGAAA ACTGAACAGA TCAATGCTGA AAGAAATGAA 1380

ATTGCAAGTG CTTCTGCCTT GTTGAAAAAA CGAAAGCCTC TTGGAATCGG TAAAGAACCT 1440

AAACGCCCAC AGGCAGTCAA TTCTCAAAAT GACTCCAACG GTATGCAGCC ATCAACAAGT 1500

TCCAATACGA ATGGAGACGA TGCGATCTTC AGACGACCTG AAGAACCGAA AGAAATCCAG 1560

TACCAAGAGT ACATTGAGCT CGATGAAATC TATAAACTGC GCAGGGAGCA CTTGAGAAAA 1620

GAAGAAACTG ATCTCTCCAT GGAGAAAGAA AGATTGGAAA AGGAGAAGCA GCATCATGTG 1680

AGAGAGCTGA AACGAGCTTC GAATGAAAGT GCGTCACAGT TCAATGATCA TCGACTCTTG 1740

CATAAAAGAT ACCTCATGCT GAACTTGCTC GGTAAGGGTG GATTCAGTGA GGTCTGGAAG 1800

GCGTTCGACA TTGAAGAGAA CCGGTATGTC GCATGCAAGA TCCATCATGT TAACAAAGAC 1860

TGGAAGGAGG AGAAGAAGGC GAACTACGTC AAGCACGCGA TGCGTGAAAA AGACATCCAC 1920

AAGTCATTGG ATCATTGCCG AATTGTGAAG CAATACGATC TGCTCACAAT CGACAATCAC 1980

TCGTTCTGCA CGGTTCTCGA ATATGTGCCG GGCAACGACC TCGATTTCTA CCTCAAGCAG 2040

AACAGGTCGA TCAGTGAGAA GGAGGCTCGA AGCATTATTA TGCAAGTTGT TTCTGCTCTT 2100

GTCTATCTGA ATGAAAAGAG CACTCCCATC ATTCATTATG ATCTAAAGCC TGCGAATATT 2160

CTTCTCGAGT CAGGAAACAC CAGCGGTGCA ATCAAGATCA CCGACTTTGG GCTGTCGAAA 2220

ATCATGGAGG GAGAGAGTGA CGATCATGAC TTGGGAATCG AGCTCACCTC ACAGTTCGCT 2280

GGAACTTATT GGTATCTTCC ACCTGAGACC TTCATCGTTC CACCACCAAA GATCACTTGT 2340

AAAGTCGATG TCTGGAGTAT TGGAGTCATC TTCTATCAAT GTATCTATGG AAAGAAGCCG 2400

TTCGGAAATG ATCTGACTCA ACAAAAGATC CTCGAATACA ATACGATTAT TAATGCAAGA 2460

GAAGTGTCAT TCCCAAGCAA GCCTCAGGTG AGCTCCGCTG CTCAAGATTT CATAAGAAGA 2520

TGCCTGCAGT ACAGGAAAGA AGACAGAGCA GATGTTTTCG AGCTGGCGAA GCATGAGCTT 2580

TTCAGACCAA GAGGAGCGAT AAGAGCCTCC GTTGCCGGAT CCGTAAGTTC TCCAAGCATT 2640

CCACGCAGTC CATCAGTGAA TCGTGAAGAT GACAATATGT AA 2682

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         yl+l+llgkggfsev+kafd++e+ryva+kih++nkdwk+ekk+nyvkha+re++ihk+l

Q: 584   YLMLNLLGKGGFSEVWKAFDIEENRYVACKIHHVNKDWKEEKKANYVKHAMREKDIHKSL  643

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dh+rivk+ydll++d++sfctvleyv+gndldfylkq++++sekearsiimq+vsal+yl

Q: 644   DHCRIVKQYDLLTIDNHSFCTVLEYVPGNDLDFYLKQNRSISEKEARSIIMQVVSALVYL  703

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         ne+++piihydlkp+nill++g+++g+ikitdfglskim+++s+d+d g+eltsq+agty

Q: 704   NEKSTPIIHYDLKPANILLESGNTSGAIKITDFGLSKIMEGESDDHDLGIELTSQFAGTY  763

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppe+f+v  +ppki++kvdvws+gvifyqc+ygkkpfg++++qq+ile+nti++a+e

Q: 764   WYLPPETFIV--PPPKITCKVDVWSIGVIFYQCIYGKKPFGNDLTQQKILEYNTIINARE  821

         **********..9***********************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         v+fpskp+vss+a++firrcl+yrkedr+dv++lak+e++

Q: 822   VSFPSKPQVSSAAQDFIRRCLQYRKEDRADVFELAKHELF  861

         ************************************9975

Domain Sequence
(FASTA)

YLMLNLLGKG GFSEVWKAFD IEENRYVACK IHHVNKDWKE EKKANYVKHA MREKDIHKSL 60

DHCRIVKQYD LLTIDNHSFC TVLEYVPGND LDFYLKQNRS ISEKEARSII MQVVSALVYL 120

NEKSTPIIHY DLKPANILLE SGNTSGAIKI TDFGLSKIME GESDDHDLGI ELTSQFAGTY 180

WYLPPETFIV PPPKITCKVD VWSIGVIFYQ CIYGKKPFGN DLTQQKILEY NTIINAREVS 240

FPSKPQVSSA AQDFIRRCLQ YRKEDRADVF ELAKHELF 278

Keyword

Alternative splicing; ATP-binding; Complete proteome; Developmental protein; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transcription; Transcription regulation; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000790	; C:nuclear chromatin
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0040018	; P:positive regulation of multicellular organism growth
GO:0045860	; P:positive regulation of protein kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0006479	; P:protein methylation
GO:0006357	; P:regulation of transcription from RNA polymerase II promoter
GO:0000003	; P:reproduction
GO:0006351	; P:transcription, DNA-dependent

KEGG

cel:CELE_C07A9.3

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013