EKS-CAE-00305

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00305

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	268.4	9.3E-80	516	779	264

Status

Unreviewed

Ensembl Protein

C24A1.3a

UniProt Accession

H2KYY2;

Protein Name

Protein Synonyms/Alias

Protein C24A1.3, isoform a;

Gene Name

C24A1.3

Gene Synonyms/Alias

C24A1.3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
C24A1.3	C24A1.3a	C24A1.3a
C24A1.3	C24A1.3b	C24A1.3b

Organism

Caenorhabditis elegans

Functional Description

Protein Length

850

Protein Sequence
(FASTA)

MGNYKSRPLT SCSDELKKKI SEGYSVVRSR LSDDVRSRSN LGWVDVQIAA FEKSLEDFKQ 60

HMCPENAELK STQLLSLFHI ICAGHSDSQP EKLQFLIDNL PKESSITLIS SQSANGFTPL 120

HIAIYRGDVA ILKALIATKL VDLDQSGRHL LPALHLAAMI GDSEMLTILL NSGANIHVTD 180

FVHFTALHCA TYFGQENAVR TLISASANLN LGGAVNDRPI HLAAAKGLTS ITKLLLEAKA 240

DPLLADDEGN QALHYAAKSG SLVILNMLIK QVRGTNDRIC ARNLYGDTAL HLSCYSGRLD 300

IVKSILDSSP TNIVNMENVF SETPLHAACT GGKSIELVSF LMKYPGVDPN YQGQDGHTAL 360

HSACYHGHLR IVQYLLENGA DQSLASRAFE GGALRQQAGP GTNRPSKVAS AIMALNRSDT 420

PSSNASYNST VSLDDQQTPV IWAYERGHDA IVALLKHYAA RTVEGDVCSE YSSGESSYTP 480

LPSPMGRLTS LTRDKADLLQ LRSALPAPFH LCLAEIEFQE SIGSGSFGKV YKGTYRGKLV 540

AVKRYRAMAF GCKSETDMLC REVSILSRLA HPNVVAFVGT SLDDPSQFAI ITEFVENGSL 600

FRRENGERKN YRVMDPAFRL RISLDVARGM RYLHESAAKP VIHRDLNSHN ILIHADGRSV 660

VADFGESRFV CQREDENLTK QPGNLRWMAP EVFSQSGKYD RKVDVFSFAL VIWEIHTAEL 720

PFSHLKPAAA AAEMTYKRGR PTLPNQPTAQ FPAHILSLIP QAWHPESSSR PDFVEIVALL 780

EPHVESTHTD ISAPSTVSQL TSQWEQLSVA PPPASKFPPI LSALHGIAAT GTVEELRQRI 840

DNNGYVINKS 850

Nucleotide Sequence
(FASTA)

ATGGGAAATT ATAAATCCAG GCCTCTAACT TCGTGTTCTG ACGAGCTGAA AAAGAAGATA 60

TCAGAAGGAT ATTCAGTGGT TAGAAGCCGA CTCAGTGATG ATGTCAGATC AAGGTCCAAT 120

TTGGGATGGG TTGACGTACA AATCGCTGCT TTTGAAAAAT CCCTCGAAGA TTTCAAGCAA 180

CATATGTGCC CAGAAAATGC GGAGCTAAAA TCTACTCAGC TTTTATCATT ATTCCATATA 240

ATTTGTGCGG GACACTCTGA CTCTCAACCT GAGAAACTTC AATTTTTAAT CGACAATCTA 300

CCCAAAGAAT CGTCTATTAC CCTGATTTCC TCTCAATCTG CAAATGGCTT CACTCCACTG 360

CACATTGCAA TTTACCGTGG TGACGTGGCA ATTTTGAAGG CTCTTATTGC AACAAAACTC 420

GTAGATCTGG ATCAATCCGG AAGGCATTTA TTACCAGCTT TACACTTGGC TGCAATGATT 480

GGAGACTCTG AAATGTTGAC TATTTTGTTG AATTCTGGAG CAAATATTCA TGTTACCGAT 540

TTTGTGCATT TTACCGCTCT TCATTGTGCC ACCTATTTCG GACAGGAAAA TGCGGTACGA 600

ACATTAATCT CTGCCTCAGC CAACTTGAAT CTCGGCGGAG CAGTAAATGA TCGCCCAATC 660

CACTTGGCAG CTGCAAAGGG TCTCACATCG ATTACGAAGC TTCTCTTAGA GGCAAAAGCT 720

GATCCTCTTC TTGCCGATGA TGAAGGGAAT CAAGCATTGC ACTACGCTGC AAAATCCGGA 780

AGCCTTGTTA TCCTCAACAT GCTCATCAAA CAAGTCCGAG GTACCAATGA TCGAATCTGC 840

GCTCGAAATC TCTACGGGGA CACCGCCCTT CACTTATCAT GCTACAGCGG CCGTCTAGAC 900

ATTGTAAAGT CAATTCTTGA TAGTTCTCCA ACAAACATTG TTAATATGGA GAACGTGTTC 960

TCAGAGACTC CGTTACATGC AGCATGTACC GGTGGAAAAT CGATAGAACT CGTTTCATTT 1020

CTCATGAAGT ATCCTGGAGT AGATCCGAAC TATCAGGGGC AGGATGGGCA TACAGCACTT 1080

CACTCTGCTT GCTACCATGG TCATCTGCGA ATTGTACAAT ACCTTCTCGA AAATGGAGCT 1140

GATCAATCCT TAGCCTCCAG GGCTTTTGAA GGGGGCGCCC TTAGACAACA AGCCGGCCCG 1200

GGCACCAATC GGCCGTCAAA GGTAGCTTCT GCGATTATGG CACTAAATCG AAGTGACACA 1260

CCTTCCTCAA ACGCATCTTA CAATTCGACA GTATCACTGG ATGACCAGCA AACTCCGGTT 1320

ATCTGGGCTT ATGAGCGTGG CCATGATGCG ATTGTGGCTC TACTCAAGCA CTATGCAGCT 1380

AGAACTGTTG AAGGGGATGT CTGCAGTGAA TACAGTTCGG GAGAATCTTC ATATACTCCG 1440

CTACCATCTC CAATGGGTCG TCTAACAAGT TTAACTAGGG ATAAGGCAGA TCTACTACAG 1500

TTGAGATCAG CGTTGCCGGC ACCATTTCAT TTGTGTTTGG CTGAGATCGA ATTCCAAGAA 1560

TCCATTGGAA GTGGTTCATT TGGAAAAGTC TACAAAGGAA CGTATCGTGG AAAACTGGTA 1620

GCCGTCAAAC GGTACAGAGC AATGGCATTT GGCTGCAAAT CTGAAACTGA CATGCTTTGT 1680

CGAGAAGTTT CCATTCTATC ACGACTGGCT CATCCGAATG TTGTAGCGTT TGTCGGGACA 1740

TCGCTAGATG ATCCGAGTCA ATTCGCAATC ATCACAGAAT TTGTAGAGAA CGGGTCCTTG 1800

TTCAGAAGAG AGAATGGAGA AAGAAAAAAT TATAGAGTCA TGGATCCAGC CTTCCGATTG 1860

AGGATATCGC TAGATGTTGC TCGTGGGATG CGTTATCTAC ACGAGAGTGC TGCCAAACCA 1920

GTTATTCACA GAGATCTCAA CAGTCATAAT ATTCTGATTC ACGCGGATGG GCGAAGTGTA 1980

GTTGCAGACT TTGGAGAAAG TCGGTTCGTT TGTCAACGAG AGGACGAGAA CTTGACGAAG 2040

CAACCCGGGA ACCTGCGATG GATGGCACCG GAGGTGTTCT CTCAATCTGG AAAATATGAT 2100

AGAAAAGTCG ACGTCTTCAG CTTTGCTCTA GTCATTTGGG AGATTCACAC CGCGGAGCTC 2160

CCATTCTCAC ACCTAAAACC TGCGGCGGCG GCGGCTGAGA TGACATATAA GCGGGGGAGA 2220

CCAACACTAC CAAATCAACC AACTGCACAG TTTCCAGCAC ACATCTTAAG CTTAATTCCT 2280

CAAGCCTGGC ATCCCGAATC AAGCTCCCGA CCAGATTTTG TAGAAATTGT TGCGTTACTC 2340

GAGCCACACG TTGAATCCAC GCACACAGAT ATAAGTGCTC CTTCTACAGT ATCCCAGTTG 2400

ACATCTCAAT GGGAGCAGCT AAGCGTGGCA CCTCCCCCCG CGTCAAAGTT CCCGCCAATT 2460

CTCTCGGCGT TACATGGGAT CGCTGCTACG GGAACCGTTG AAGAATTAAG GCAACGGATT 2520

GATAATAATG GTTATGTTAT TAATAAGAGT TGA 2553

Domain Profile

S: 1     ieleeligsgafgkvykakwrkkevavKklreeaee.kekleklereakllsklshpnii  59

         ie++e igsg+fgkvyk+++r+k vavK++r++a   k+++++l+re+++ls+l+hpn++

Q: 516   IEFQESIGSGSFGKVYKGTYRGKLVAVKRYRAMAFGcKSETDMLCREVSILSRLAHPNVV  575

         5799*****************************998899*********************

S: 60    ellGvcleepn.lllvmeyveggsLsnvlhe..kskreidlevlvswalqiArGmaYLhs  116

         +++G++l++p+ +++++e+ve+gsL++  ++  k+ r++d++  ++++l++ArGm+YLh+

Q: 576   AFVGTSLDDPSqFAIITEFVENGSLFRRENGerKNYRVMDPAFRLRISLDVARGMRYLHE  635

         ***********89****************997788899**********************

S: 117   eapkkiihrdLksknvLlseekktlkicdFGtarelsk..stkmsaa.gtlawmaPEvl.  172

         +a+k++ihrdL+s+n+L+ +++ +  ++dFG++r++++  +++ +++ g+l+wmaPEv+

Q: 636   SAAKPVIHRDLNSHNILI-HADGRSVVADFGESRFVCQreDENLTKQpGNLRWMAPEVFs  694

         ******************.999**************998766677777***********9

S: 173   keekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpips....scpek  228

         ++ k+++k+Dv+S+++v+We++t e P+++l+++a+a+++++k+ r+++p+    ++p++

Q: 695   QSGKYDRKVDVFSFALVIWEIHTAELPFSHLKPAAAAAEMTYKRGRPTLPNqptaQFPAH  754

         99************************************************988889****

S: 229   lkkLmkecwnedpekRpsfseivks  253

         + +L+ ++w+ ++++Rp+f eiv

Q: 755   ILSLIPQAWHPESSSRPDFVEIVAL  779

         *********************9975

Domain Sequence
(FASTA)

IEFQESIGSG SFGKVYKGTY RGKLVAVKRY RAMAFGCKSE TDMLCREVSI LSRLAHPNVV 60

AFVGTSLDDP SQFAIITEFV ENGSLFRREN GERKNYRVMD PAFRLRISLD VARGMRYLHE 120

SAAKPVIHRD LNSHNILIHA DGRSVVADFG ESRFVCQRED ENLTKQPGNL RWMAPEVFSQ 180

SGKYDRKVDV FSFALVIWEI HTAELPFSHL KPAAAAAEMT YKRGRPTLPN QPTAQFPAHI 240

LSLIPQAWHP ESSSRPDFVE IVAL 264

Keyword

ANK repeat; Complete proteome; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity

KEGG

cel:CELE_C24A1.3

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF00023	; Ank; 7.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 9.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 4.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013