EKS-CAE-00243

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00243

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	416.4	8.8E-125	265	602	338

Status

Reviewed

Ensembl Protein

C32D5.2

UniProt Accession

Q09488;

Protein Name

Serine/threonine-protein kinase sma-6

Protein Synonyms/Alias

Gene Name

sma-6

Gene Synonyms/Alias

sma-6; C32D5.2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
C32D5.2	C32D5.2	C32D5.2

Organism

Caenorhabditis elegans

Functional Description

Involved in TGF-beta pathway. May be a receptor for daf-7.

Protein Length

636

Protein Sequence
(FASTA)

MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV LKEMKLRNRP 60

NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN KAEKRMETLH KWGCATLERG 120

SGASHLTCNS WRAAHHSPKS IGCCYEGNYC NKNLIPPAYV HHHKEKALQE KTDNPEDYDS 180

PLENMTRGGK MFIMVFATVM SVFAVIGCIY LCITRAEEKS KARARAKTVS LKTESTYMES 240

KSMLEDSGSG SGQAALIQRT VRQDLTIIKT IGQGRYGEVR KALYRGSYVA VKTFYTTDED 300

SWKNERDVYQ TNMINHENIL QFVAADIWSE EDSMTKMLLI TDYHELGSLS DYLCREETLT 360

TDEALRLIHS CICGIEHLHA AVHGTGSFRK PEIAHRDIKS KNIIVKRPNV CCIADLGLAL 420

RYQNDKILPE KFNVQVGTKR YMAPELISNK LNPKDFSQFK MADIYSMALV MWEVAIRVEV 480

NTCEEVLTVD ETSPDHSASS GIGESVSSSG NISRMHLQKT NVEGHSTSLK AKQHVPPFDG 540

IVHNDPNFDE MNDVICVRRI RPPPDLAWKN VPALNELSKL MEDSWHSIPH FRHSALKLKK 600

EMAELIKNPD RQNQSQRKVE FQQQDSGLVE SATNQS 636

Nucleotide Sequence
(FASTA)

ATGAACATCA CCTTTATATT TATTCTCATT TTCGGATTTT TCAATACTCA AAAATGCTCA 60

AAAGACTATG ATCACTTTGA CGATGAAGAC TTAGCGTTGA GCATTCCAAA AAATGCAATA 120

GGAGTTCCAA AGGAGTTCAG GCAACAAGTT TTAAAAGAGA TGAAGCTTCG GAACAGACCC 180

AATGATATTT TGAAAAATCG ATGTTATTGC AATTATGATC AGTCGATATG TGGAAATAAT 240

ATGACATGTG TGAAACAAGA TGGAGCTGCT TGTTATCATG CCGTTGAAGA GGTTTATAAC 300

AAAGCTGAAA AACGAATGGA AACTCTTCAT AAATGGGGAT GTGCAACACT GGAAAGAGGA 360

AGTGGAGCTT CACATTTGAC GTGTAATTCT TGGAGAGCAG CTCACCATTC TCCTAAAAGT 420

ATTGGTTGTT GCTATGAAGG TAACTATTGC AATAAGAATT TGATTCCGCC GGCATATGTT 480

CATCATCACA AGGAGAAAGC ACTTCAAGAG AAAACTGACA ATCCAGAAGA CTATGATTCT 540

CCACTGGAAA ACATGACACG TGGAGGAAAA ATGTTCATAA TGGTATTTGC AACAGTCATG 600

TCGGTTTTTG CAGTCATTGG ATGTATTTAT TTATGTATTA CAAGAGCAGA AGAAAAATCT 660

AAAGCCAGAG CCAGAGCCAA GACGGTGTCT CTGAAAACAG AATCAACATA CATGGAGAGC 720

AAATCAATGC TCGAAGACTC AGGAAGTGGT TCTGGGCAGG CTGCGTTGAT CCAAAGGACA 780

GTGAGACAAG ATTTAACAAT TATTAAAACA ATTGGACAGG GAAGATATGG AGAAGTTCGC 840

AAAGCTCTGT ATCGTGGAAG TTACGTGGCT GTAAAAACAT TCTACACAAC TGATGAAGAT 900

TCATGGAAAA ATGAAAGAGA TGTATATCAA ACTAACATGA TCAATCATGA AAATATCCTT 960

CAATTCGTGG CGGCTGATAT TTGGAGTGAG GAAGATTCAA TGACAAAGAT GCTTCTTATC 1020

ACTGATTATC ATGAACTGGG ATCTTTATCA GATTATCTTT GCCGTGAAGA AACATTGACA 1080

ACAGATGAAG CTCTTCGACT TATTCACAGT TGTATATGTG GTATTGAACA TCTACATGCA 1140

GCTGTACACG GAACTGGAAG CTTTAGAAAA CCTGAAATTG CACATCGAGA TATTAAATCA 1200

AAGAATATTA TAGTCAAACG ACCAAATGTG TGTTGTATCG CTGATTTGGG TTTGGCACTA 1260

CGATATCAAA ACGACAAAAT TCTCCCTGAA AAATTCAATG TTCAAGTTGG AACAAAACGA 1320

TATATGGCTC CAGAACTGAT ATCAAACAAG TTGAATCCAA AAGATTTTTC TCAGTTCAAG 1380

ATGGCAGATA TCTACTCAAT GGCACTTGTT ATGTGGGAAG TTGCAATCAG GGTTGAGGTA 1440

AACACCTGTG AGGAAGTGTT AACTGTCGAT GAGACCTCTC CTGATCACAG TGCATCAAGT 1500

GGTATCGGAG AGTCAGTTAG TTCATCTGGT AATATATCGA GAATGCATCT ACAAAAAACA 1560

AATGTAGAAG GACATTCTAC ATCTCTGAAA GCAAAACAAC ATGTCCCACC ATTCGATGGA 1620

ATCGTGCACA ATGATCCCAA TTTTGACGAG ATGAACGATG TAATTTGTGT ACGTCGAATA 1680

CGTCCACCAC CGGATCTTGC CTGGAAAAAC GTCCCAGCAC TTAATGAATT GAGCAAGTTG 1740

ATGGAAGACA GTTGGCATTC AATTCCACAC TTCCGACATT CTGCTCTTAA ATTGAAAAAA 1800

GAAATGGCTG AGTTGATCAA AAACCCCGAC AGACAGAATC AATCGCAGCG TAAAGTTGAA 1860

TTCCAACAGC AAGACAGTGG CCTTGTTGAG TCAGCCACCA ATCAATCTTA A 1911

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+++++ig+GrygeV+ka +rg++vAvK+f+t+de+swk+E+++yqt++++henilqf+a

Q: 265   LTIIKTIGQGRYGEVRKALYRGSYVAVKTFYTTDEDSWKNERDVYQTNMINHENILQFVA  324

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkr.etldveellrlalslasGlahLHeeivg  118

         ad+ +eeds+t++ll+t+yhe gsLsdyL+r etl+++e+lrl++s+++G++hLH++++g

Q: 325   ADIwSEEDSMTKMLLITDYHELGSLSDYLCReETLTTDEALRLIHSCICGIEHLHAAVHG  384

         ******************************989***************************

S: 119   tkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYma  178

         t  ++Kp+iaHRD+kskNi+vk++++cciaDlGLal+++++k  l +++n+qvGtkRYma

Q: 385   TGSFRKPEIAHRDIKSKNIIVKRPNVCCIADLGLALRYQNDKI-LPEKFNVQVGTKRYMA  443

         *99**************************************99.8889************

S: 179   PEvleealnlkdfeafkraDvYslgLvlWEvasR.....cee...vdeeveey.......  223

         PE+++++ln kdf++fk+aD+Ys++Lv+WEva+R     cee   vde+++++

Q: 444   PELISNKLNPKDFSQFKMADIYSMALVMWEVAIRvevntCEEvltVDETSPDHsassgig  503

         **********************************7777666677677788888*******

S: 224   ...............................klpfeevvgsdPsleemkevvvekklrPk  252

                                         +pf+ +v++dP+++em++v++++++rP

Q: 504   esvsssgnisrmhlqktnveghstslkakqhVPPFDGIVHNDPNFDEMNDVICVRRIRPP  563

         ***************************997669***************************

S: 253   ipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

          + awk+++al+elskl+e++W++ p++R++al++kk++

Q: 564   PDLAWKNVPALNELSKLMEDSWHSIPHFRHSALKLKKEM  602

         *************************************97

Domain Sequence
(FASTA)

LTIIKTIGQG RYGEVRKALY RGSYVAVKTF YTTDEDSWKN ERDVYQTNMI NHENILQFVA 60

ADIWSEEDSM TKMLLITDYH ELGSLSDYLC REETLTTDEA LRLIHSCICG IEHLHAAVHG 120

TGSFRKPEIA HRDIKSKNII VKRPNVCCIA DLGLALRYQN DKILPEKFNV QVGTKRYMAP 180

ELISNKLNPK DFSQFKMADI YSMALVMWEV AIRVEVNTCE EVLTVDETSP DHSASSGIGE 240

SVSSSGNISR MHLQKTNVEG HSTSLKAKQH VPPFDGIVHN DPNFDEMNDV ICVRRIRPPP 300

DLAWKNVPAL NELSKLMEDS WHSIPHFRHS ALKLKKEM 338

Keyword

ATP-binding; Complete proteome; Developmental protein; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0036122	; F:BMP binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0004675	; F:transmembrane receptor protein serine/threonine kinase activity
GO:0030509	; P:BMP signaling pathway
GO:0010171	; P:body morphogenesis
GO:0040024	; P:dauer larval development
GO:0050832	; P:defense response to fungus
GO:0045087	; P:innate immune response
GO:0051457	; P:maintenance of protein location in nucleus
GO:0040018	; P:positive regulation of multicellular organism growth
GO:0045732	; P:positive regulation of protein catabolic process
GO:0045944	; P:positive regulation of transcription from RNA polymerase II promoter
GO:0030155	; P:regulation of cell adhesion
GO:0000003	; P:reproduction
GO:0023014	; P:signal transduction by phosphorylation
GO:0045138	; P:tail tip morphogenesis

KEGG

cel:CELE_C32D5.2

;

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR003605	; TGF_beta_rcpt_GS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.
PF08515	; TGF_beta_GS; 1.

SMARTs

SM00467

; GS; 1.

Prosites

PS51256	; GS; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013