EKS-CAE-00404

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00404

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	390.0	5.8E-117	12	274	263

Status

Unreviewed

Ensembl Protein

C33F10.2

UniProt Accession

Q18386;

Protein Name

Protein Synonyms/Alias

Protein TBCK-1;

Gene Name

tbck-1

Gene Synonyms/Alias

tbck-1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
C33F10.2	C33F10.2	C33F10.2

Organism

Caenorhabditis elegans

Functional Description

Protein Length

841

Protein Sequence
(FASTA)

MGSFPNFGAF ILRAQEKDGR TCINGLPVAS PAKQMLGRFP YLQSLQHDNL SVYLHFSETV 60

IARDLVIVVM EHYTMNLEDI LKTGNLKDES LNNNFYSEIS SALDYLHTRN IVHGFLHLNS 120

IYITDRKNQK LSVKLSGYGL PFLTNYGKDT ASSIKFGAFL APERILNDED SLFAATYQSD 180

VWELGFIILQ IYLGISLEAE VTETEYLEIL NKYYTDDQEK LSTVMEDLIQ LLADKKRLPY 240

HKKCEWLEAI IRKCLQMCCS KRCSITEVAA EIEININGVK NNNNKYEYKV KTVEEMRAAV 300

RKEVADNNDG FEKLSVENSF YLWKTCGSTP EIILLKKGII QNHAPISSYP TVRFDDFLRL 360

DSGVDSQSTF EYGVFDLPSK KTLTRKETGQ RVSARMFHKI GILEDKDLLN GNILYETASN 420

MLTVDHLLNA SAVFGISSII SRLTNIGVIP TQRADVWCTL LDINETKWRD YLNLDVLASH 480

SSDRQLEVDI PRCHQYDSYM TTPAIQESLR KVLKGWQIVT ESQHFVYWQG CDSLATPFLL 540

ANMSKPHVAF ACFKEFTYRY CHKFYLKDNS EVIKEYLGIF YHLVAYTDPV LYKHLKINGF 600

DAELFAIPWF LTCFAHELPL SKLVLLWDET MMHGNAFPLM IALAMLNRLR DKLLAVNFNE 660

MIIIIHDQPD LSIDEIIKNS RGYEKLIPPS CTFRAHASPW KGTKNYAGDI YCLPNSMAGL 720

SLQQLSSIHC PRMSSEELIW RIERKMVYVL DTRQESEFQS ERFSDSFNHP NNNHEADIDW 780

LRFLPGIVCS ELPKCFVYGK NDKEAAERLT EAYVMKGVPY ICLLHDHFEA VRNRDSVVVK 840

P 841

Nucleotide Sequence
(FASTA)

ATGGGTAGTT TTCCAAACTT CGGAGCATTC ATACTTCGAG CACAAGAGAA AGACGGAAGA 60

ACTTGTATAA ATGGCTTACC GGTCGCTTCT CCAGCCAAAC AAATGCTCGG AAGATTTCCA 120

TATTTGCAAT CTCTTCAACA TGATAATCTA TCGGTTTACC TTCATTTCTC TGAAACCGTT 180

ATTGCTCGCG ATTTGGTTAT TGTCGTGATG GAGCATTACA CTATGAATCT TGAAGATATA 240

TTGAAAACTG GAAATTTAAA AGATGAAAGT TTAAACAATA ATTTCTACTC TGAAATATCA 300

TCAGCACTCG ATTATCTACA TACACGAAAT ATTGTACACG GATTTCTTCA TCTTAATTCA 360

ATATATATCA CCGATCGTAA AAATCAGAAA TTATCAGTGA AACTTTCTGG ATATGGACTA 420

CCGTTTTTAA CAAATTACGG TAAGGATACC GCTTCATCGA TAAAATTTGG CGCATTTTTG 480

GCTCCGGAGA GAATATTGAA TGATGAGGAT TCTTTATTTG CCGCCACTTA TCAATCAGAT 540

GTTTGGGAAT TGGGATTTAT TATTTTACAA ATTTATTTGG GAATCTCACT GGAAGCCGAA 600

GTTACTGAGA CGGAATACTT GGAAATACTC AATAAATACT ACACAGATGA TCAGGAGAAG 660

CTTAGCACTG TCATGGAGGA TCTTATTCAA CTATTAGCTG ATAAAAAGCG ACTACCATAT 720

CACAAAAAAT GTGAATGGCT GGAAGCAATT ATTCGGAAAT GTCTTCAAAT GTGCTGCTCC 780

AAACGATGTT CTATAACAGA AGTGGCTGCT GAGATTGAAA TAAATATTAA TGGAGTGAAG 840

AATAACAATA ATAAATATGA ATATAAAGTG AAAACGGTGG AAGAAATGCG TGCAGCCGTT 900

AGAAAAGAAG TAGCAGATAA TAATGATGGA TTTGAAAAGT TATCAGTTGA AAATTCATTT 960

TATTTATGGA AAACCTGCGG ATCAACACCG GAAATAATTT TGCTCAAGAA AGGAATAATA 1020

CAGAATCATG CTCCAATATC ATCTTATCCA ACAGTTCGAT TTGATGATTT TTTACGATTA 1080

GATTCAGGAG TTGATAGTCA ATCAACTTTT GAATATGGGG TTTTTGATCT GCCGAGTAAG 1140

AAAACTTTGA CTCGAAAAGA AACCGGTCAG AGGGTGTCTG CACGAATGTT TCACAAAATT 1200

GGCATTCTAG AGGACAAGGA TCTTCTGAAC GGAAATATTC TCTATGAAAC AGCTTCAAAT 1260

ATGCTCACAG TTGATCATCT TTTGAATGCT TCGGCAGTTT TTGGAATATC CTCGATTATA 1320

TCTCGACTTA CAAATATTGG TGTCATTCCT ACCCAAAGAG CCGATGTCTG GTGCACACTA 1380

TTGGATATAA ACGAAACAAA ATGGCGTGAT TATCTGAATC TTGATGTTCT CGCATCACAT 1440

TCCAGTGATC GTCAGCTTGA AGTGGATATT CCACGTTGTC ATCAATATGA TAGTTACATG 1500

ACAACTCCAG CAATTCAAGA ATCACTTCGA AAAGTTCTGA AAGGATGGCA AATTGTCACG 1560

GAATCTCAAC ATTTTGTCTA TTGGCAAGGA TGTGACAGTT TGGCAACTCC ATTTTTATTA 1620

GCGAATATGA GTAAACCTCA TGTAGCATTC GCCTGTTTCA AAGAATTCAC ATATCGATAT 1680

TGTCATAAAT TTTATTTGAA AGATAATTCG GAAGTGATCA AAGAATATCT TGGCATCTTC 1740

TATCATCTCG TTGCATACAC AGACCCAGTC CTCTACAAAC ACCTGAAAAT CAATGGATTC 1800

GACGCTGAAC TCTTCGCAAT TCCATGGTTC TTAACATGCT TTGCCCATGA GCTTCCACTA 1860

TCCAAACTTG TACTTCTTTG GGATGAAACA ATGATGCATG GAAATGCATT CCCATTAATG 1920

ATTGCTCTTG CCATGTTGAA CCGTCTCAGA GATAAACTTT TGGCTGTGAA TTTCAACGAA 1980

ATGATTATCA TAATTCATGA TCAACCTGAT TTGTCTATCG ATGAGATTAT AAAAAATTCA 2040

CGTGGATATG AGAAGCTCAT CCCTCCAAGT TGTACGTTCC GCGCCCATGC TAGTCCATGG 2100

AAAGGTACTA AAAACTATGC TGGGGACATT TATTGTCTTC CAAATTCTAT GGCAGGCCTT 2160

TCACTTCAAC AACTTTCCAG TATTCATTGT CCACGAATGT CATCAGAAGA GTTAATATGG 2220

AGAATTGAAA GAAAAATGGT TTATGTGCTA GACACCCGGC AGGAATCAGA ATTCCAATCC 2280

GAGCGATTCT CCGACTCTTT TAATCATCCG AACAATAACC ATGAAGCTGA CATCGATTGG 2340

CTCAGATTCC TGCCAGGAAT TGTTTGCAGT GAACTGCCAA AGTGCTTCGT GTATGGAAAG 2400

AATGACAAAG AAGCTGCCGA GCGTCTAACC GAAGCTTATG TGATGAAAGG AGTTCCATAT 2460

ATTTGCCTAC TTCATGATCA TTTTGAAGCA GTTAGAAATC GTGATTCAGT TGTTGTGAAG 2520

CCATAA 2526

Domain Profile

S: 1     llaqdkdGs...nGlplasnakkilGrfqiLkelqhdrLcqYldisrg..khervivvae  55

         l+aq+kdG+   nGlp+as+ak++lGrf++L++lqhd+L++Yl++s++  ++++vivv+e

Q: 12    LRAQEKDGRtciNGLPVASPAKQMLGRFPYLQSLQHDNLSVYLHFSETviARDLVIVVME  71

         589*********************************************************

S: 56    hlelsLeDllkerkpvseslvlriayevlsgldylnkhnivhralepksill.drkgqk.  113

         h++++LeD+lk++++++esl++++++e++s+ldyl+++nivh++l+++si++ drk+qk

Q: 72    HYTMNLEDILKTGNLKDESLNNNFYSEISSALDYLHTRNIVHGFLHLNSIYItDRKNQKl  131

         ************************************************************

S: 114   .vkLakyGLyhltayGkdvdfpigygsylaPerilqdedkllaatvksDvWsLglillel  172

          vkL++yGL++lt+yGkd++++i++g++laPeril+ded+l+aat++sDvW+Lg+i+l++

Q: 132   sVKLSGYGLPFLTNYGKDTASSIKFGAFLAPERILNDEDSLFAATYQSDVWELGFIILQI  191

         ************************************************************

S: 173   ilgikLfaeldlserlkil........lklstvdetliklaeekkcldiikklderleal  224

         +lgi+L+ae++++e+l+il        +klstv+e+li+l+++kk+l+++kk+ e+lea+

Q: 192   YLGISLEAEVTETEYLEILnkyytddqEKLSTVMEDLIQLLADKKRLPYHKKC-EWLEAI  250

         *****************************************************.******

S: 225   lkkCLtllpskRpspdellkekvf  248

         ++kCL++++skR+s++e+++e+++

Q: 251   IRKCLQMCCSKRCSITEVAAEIEI  274

         ********************9875

Domain Sequence
(FASTA)

LRAQEKDGRT CINGLPVASP AKQMLGRFPY LQSLQHDNLS VYLHFSETVI ARDLVIVVME 60

HYTMNLEDIL KTGNLKDESL NNNFYSEISS ALDYLHTRNI VHGFLHLNSI YITDRKNQKL 120

SVKLSGYGLP FLTNYGKDTA SSIKFGAFLA PERILNDEDS LFAATYQSDV WELGFIILQI 180

YLGISLEAEV TETEYLEILN KYYTDDQEKL STVMEDLIQL LADKKRLPYH KKCEWLEAII 240

RKCLQMCCSK RCSITEVAAE IEI 263

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

cel:CELE_C33F10.2

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.
IPR001763	; Rhodanese-like_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.

SMARTs

SM00164

; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013