EKS-CAE-00083

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00083

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	301.6	1.2E-89	1751	2063	313

Status

Reviewed

Ensembl Protein

C48B6.6a

UniProt Accession

O01510; Q6BEW0; Q9U9U7;

Protein Name

Serine/threonine-protein kinase smg-1

Protein Synonyms/Alias

Suppressor with morphogenetic effect on genitalia protein 1;

Gene Name

smg-1

Gene Synonyms/Alias

smg-1; C48B6.6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
C48B6.6	C48B6.6a	C48B6.6a
C48B6.6	C48B6.6b	C48B6.6b

Organism

Caenorhabditis elegans

Functional Description

Serine/threonine protein kinase involved in mRNAsurveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating smg-2.

Protein Length

2322

Protein Sequence
(FASTA)

MITSRNNDIG NLIEQFRQRD TPQKERKAIL ARIEEILQTT KNVESLCVKW TYLLDNLCWP 60

SLTKHDRNDM KTLAGKVIRL VGVLLFDTES YPEFLIYLGT LYQSVTKKSE ETRADIVFSV 120

YFIVGVISQK TENRLIATDT ENVEKSLDWI IKVLPNSSIS VYNHCLKGFV LVANTFPNVY 180

AAMFESTLRA ILTNLPDFNS HEKNFELLID TVMRFSDQLN EKPHLAEEMV RIIRPDIKKN 240

GLGNMRELKK RMKLTMALVK MAKSQKMLEE TNQMISEMSI ELEENGGKWS SASLITIVCD 300

VFNELLILGK DDVKLQKGVE ESLCNVLKDL NLSNQSTMEK QAFFNSLAKI VKQLPAESQV 360

KTRVHQIVFN TETGLFTPKN RDNRMFGHNM IYKDLINLVS VLLTPTSLNH LQATYTDLRK 420

IMIDSMSRLK QSEDTPYSDN IRWNESILLL FFSSLQSISC AKSSLIVMMG IRPSIFEFFS 480

SELPLTEYWL ASNHPEVYHL FITIFVGHLK AHDFYIVQSD YIVRGDSIGQ SIGQTKRDYA 540

RKQVVALQKI INNFGDKLWK KTRLMISSWL HSLIATACEH QIGSDSFSQR EWVRLRNTVI 600

HQSVLTWNNE CVNQALTILS TATKWSELTS DIHRDIADKT KKAKWKEATT IWESGDCNTY 660

IRQSMSTVYQ MSQERQQKTI TSTSFGAEEF IIITNFLLKQ ATPTTFKKGQ NSWMDEVLET 720

FTQGCRTLEK PDSYVPETFI EKWDWIINQT ANFCIVNKMK TPLGKPMQTF AAFENEIKRL 780

AKEVIVRKNS DKKLNKSSTE DPNQSPPLKY SVQWLRVHLL LKLIVVLEKL MNSAIHGGSS 840

VFNLTEIPVS SRQFFTVNAA SCEVWLNRVY YPALLVAYFN GYYGLVIRFG SNALSHFARQ 900

KDGDNDKKIV NGVCTASLMS LSMAVLGEPM EIVGLRRKVR EEFGTDMGQS LMEALGEMAN 960

ARYETALVAL EAVLVTDAAT NETLKMIIQL AMVDILNRIR LPQATDYYKV VLFGEESNDS 1020

TITEDFRSVE LLTKFEKLNN TVNEKRQVVD WSARERFQFV ESAFSQTMRR TELLDIQKDF 1080

SAMGALALSA DSSCKLYSDI SSTSLIIANL VNKMTGVSQW KNKLTDTEIF DRNEEGNDGD 1140

KLAICRKLMH WGRHTKSNRG QSCAAHSEII RLSRKTSNCE LAFFHINSAI RGEKLAAWQR 1200

LEVERQRLKL VKTQNLDVRI REMNEVFGSL AEVFTTSCQL KSDFQMVDGM IKEKMISEGY 1260

NEDIAKREEH MSRASIQLAD FFQSLPELEN VLAPNLFPTI IWSELQRRSD SLSAGYHGIV 1320

GSLFHLASEM CPSLAKAHLK MARWAYEIAK IKNFPAENLS FYKFGKDETE NEELLKSLEA 1380

TSLVNLEKLV RAAISDDLRA NNILAPNSHF MHIWKMVRDH RTKFLSIAVT SYFQFIQNMS 1440

GDCDNLPYSK KEETTLATLR ILELLVKHGD VLIDVINDGL NKTNVHIWKE ILPQLFARLS 1500

HPSEHIRKTL VDLISKICTA APHAVVFQVV SGAASSSTDG EELEEQQNDD RNRVRACCEK 1560

LETNMSQSYP NLVKDVRQFV AELERINLLN EEKWSVVMGT MEHEMEKRLS LIRTENAKTE 1620

SALHLTASVK NDIIVKRTQL LTRQIFDVLD ELYQQTVIEP PKSKNEEEFV TAFAEVLTNA 1680

FQESRISRTT SPEKSWIPFK NLIANFVHRN SKKGMQTFET EDISPYLASL SNSCVPMPGQ 1740

ESVEFDRVVS ISRVARQVTI LPTKTRPKKL GFVGSDGKQV AFLFKGREDL HLDERVMQFL 1800

RLCNVMLQPG KGKHRQSVAA YQAHHYAVIP LGPRSGLIKW VEGATPMFHI YRKWQMKEKA 1860

LKQATKKNGE TVPEIERPSN MYHNMIRLAF ADHKIDSSIT SDRSKWPAEI LEEVFESLTA 1920

KTPTDLISRE LWMRANDATT WWSVTKRYSR SLAVMSMVGS VLGLGDRHLD NLLVDLKWGH 1980

VVHIDYNICF DKGKNLRIPE TVPFRLTRNM RHALGPSEMY GTFRESCVHV LSTLRSGHQV 2040

LTMLLDAFVF DPLVDWTSHE HTATSGVSLA LQLAVYGSNW KTKAKERLTD AMELLNLRMS 2100

EVQTLWLANR DDLLHWMKQV TECLLIENSM LGANAIYAQQ RVKAGTELRE AVTRHHALAK 2160

ELRPLIRVIG KEREEFADYL KFYKQALFDP LLKGHSALRN ELDIDTCVYN FNIVMQNIDN 2220

VFGALVNLSF TPIETITSRT SQQEFKPPPG LENVWVVKQD QQENSQAREV VRRVERRLNG 2280

WLDGSAGPDR KLSPREEADI LIAEATSTPN LSQMYEGWTA WV 2322

Nucleotide Sequence
(FASTA)

ATGATAACAT CGAGAAACAA TGATATTGGG AACCTGATAG AACAGTTTCG TCAACGTGAC 60

ACGCCACAGA AGGAACGGAA AGCGATTCTC GCTAGAATCG AGGAGATTCT TCAAACTACG 120

AAAAATGTAG AGAGTCTTTG TGTAAAATGG ACTTATCTTT TGGATAACTT GTGTTGGCCT 180

AGTCTCACAA AACACGATCG GAATGACATG AAAACGCTGG CTGGAAAAGT GATACGACTT 240

GTTGGAGTTT TACTCTTTGA TACTGAATCC TATCCAGAGT TTCTGATTTA TCTTGGAACA 300

TTATATCAAA GTGTTACGAA GAAAAGTGAA GAAACACGTG CGGATATCGT GTTTTCAGTG 360

TATTTCATCG TTGGAGTCAT CAGTCAAAAA ACGGAGAATC GTCTAATTGC TACCGACACT 420

GAAAATGTCG AAAAATCATT AGACTGGATA ATCAAAGTGC TTCCGAATTC ATCAATATCA 480

GTTTATAACC ACTGTTTGAA AGGATTTGTA CTTGTTGCAA ACACATTTCC AAATGTTTAT 540

GCTGCAATGT TTGAGTCAAC CCTCCGAGCA ATTCTGACCA ACCTTCCCGA TTTCAACAGT 600

CATGAAAAGA ATTTTGAGCT TCTCATTGAT ACAGTGATGC GATTTTCTGA TCAACTTAAT 660

GAGAAGCCTC ATTTGGCAGA AGAAATGGTT CGAATTATTC GACCGGATAT CAAAAAGAAT 720

GGATTGGGAA ATATGAGAGA ATTGAAGAAA CGAATGAAAC TGACAATGGC ACTCGTGAAA 780

ATGGCGAAAA GTCAAAAAAT GCTTGAGGAG ACTAATCAGA TGATTTCTGA AATGTCTATC 840

GAACTCGAGG AAAACGGAGG AAAATGGTCA TCAGCTTCAC TTATAACTAT CGTTTGTGAT 900

GTTTTCAATG AGCTCTTGAT ATTGGGAAAA GATGATGTAA AATTGCAAAA AGGAGTTGAA 960

GAATCATTGT GCAATGTTCT GAAAGACTTG AATCTTTCTA ATCAGAGTAC TATGGAGAAA 1020

CAAGCATTTT TCAATTCTCT TGCAAAGATT GTCAAACAAC TTCCAGCAGA GTCACAAGTC 1080

AAAACTAGAG TTCATCAGAT TGTTTTCAAC ACGGAAACTG GACTTTTCAC ACCCAAAAAC 1140

CGCGATAATC GAATGTTTGG ACATAATATG ATATACAAGG ATCTTATCAA TCTTGTCTCT 1200

GTGCTTCTTA CGCCTACATC ACTCAATCAT CTACAAGCGA CATATACGGA TTTGAGGAAA 1260

ATAATGATAG ATAGCATGTC ACGATTGAAG CAAAGTGAAG ATACTCCGTA TAGTGATAAT 1320

ATTCGATGGA ATGAATCAAT CCTTTTGCTT TTCTTTTCGT CACTTCAAAG TATATCATGT 1380

GCCAAGAGTT CTCTTATTGT GATGATGGGA ATCCGTCCGT CAATTTTTGA ATTCTTCTCA 1440

TCGGAACTTC CACTCACAGA ATATTGGCTT GCTTCAAATC ATCCAGAAGT CTATCACCTA 1500

TTTATCACAA TATTTGTTGG ACATTTGAAA GCTCACGACT TCTACATTGT TCAATCTGAT 1560

TATATTGTTC GTGGTGATAG CATTGGACAA AGTATAGGAC AAACGAAACG AGATTATGCA 1620

CGGAAACAAG TTGTTGCTCT ACAGAAAATT ATCAACAATT TTGGAGACAA ATTGTGGAAG 1680

AAGACTAGAC TGATGATATC TTCATGGCTT CACTCTCTCA TTGCAACTGC TTGTGAACAT 1740

CAAATCGGAA GTGATAGTTT CAGTCAACGA GAATGGGTTC GATTAAGGAA TACTGTCATT 1800

CATCAGTCGG TGCTCACATG GAATAATGAA TGTGTAAATC AAGCATTGAC CATCCTCTCC 1860

ACTGCTACAA AATGGTCAGA ACTGACGTCA GACATCCATC GAGATATTGC GGATAAAACG 1920

AAAAAAGCAA AGTGGAAGGA GGCAACGACA ATTTGGGAAT CTGGAGATTG TAATACTTAT 1980

ATCAGGCAAT CCATGTCTAC AGTCTATCAA ATGTCACAGG AACGACAACA GAAGACAATT 2040

ACATCGACAA GTTTTGGAGC CGAAGAGTTT ATAATAATTA CGAATTTCTT GTTGAAACAG 2100

GCAACACCAA CTACTTTCAA AAAAGGTCAA AACTCATGGA TGGATGAAGT ACTGGAAACA 2160

TTCACACAAG GATGTCGTAC GCTTGAAAAA CCCGATTCAT ACGTTCCAGA GACATTTATC 2220

GAAAAATGGG ATTGGATTAT TAATCAGACT GCAAACTTTT GCATTGTGAA TAAAATGAAG 2280

ACACCATTAG GAAAACCAAT GCAGACTTTT GCAGCTTTTG AGAATGAAAT TAAACGACTT 2340

GCGAAAGAAG TGATTGTTCG AAAGAATAGT GATAAGAAGT TGAATAAATC ATCTACAGAA 2400

GATCCAAATC AATCTCCACC ACTCAAATAT TCCGTTCAAT GGCTTCGTGT TCATTTACTT 2460

CTAAAATTGA TTGTAGTTTT GGAAAAACTT ATGAACTCAG CCATTCATGG TGGTTCTTCC 2520

GTTTTCAATT TGACTGAAAT TCCAGTGTCC TCTCGCCAAT TTTTCACAGT GAACGCAGCA 2580

AGTTGTGAGG TTTGGCTGAA TCGAGTATAC TATCCTGCTC TTCTTGTCGC ATATTTCAAT 2640

GGATATTATG GACTTGTTAT TCGATTTGGT TCAAATGCTC TTAGCCATTT CGCGAGACAA 2700

AAAGACGGAG ATAATGATAA AAAGATCGTG AATGGCGTTT GTACAGCAAG TTTAATGTCA 2760

CTTTCAATGG CAGTTCTCGG TGAACCAATG GAAATTGTTG GATTACGGAG AAAAGTTCGA 2820

GAAGAATTCG GAACTGACAT GGGACAATCA TTGATGGAGG CACTCGGAGA AATGGCTAAT 2880

GCTAGATATG AGACAGCTCT GGTTGCCTTG GAAGCAGTTC TTGTGACAGA TGCAGCAACA 2940

AATGAAACAT TGAAAATGAT CATTCAACTA GCAATGGTTG ACATTTTGAA CCGCATACGC 3000

CTCCCACAGG CTACCGATTA TTATAAGGTT GTCTTATTTG GTGAAGAATC AAATGATTCC 3060

ACAATTACTG AAGACTTTCG ATCAGTTGAG TTACTCACGA AATTCGAGAA GCTCAACAAT 3120

ACAGTGAACG AAAAGCGTCA AGTTGTTGAT TGGAGTGCTC GAGAACGTTT CCAATTTGTT 3180

GAATCCGCAT TTTCACAGAC TATGAGAAGA ACCGAACTTC TCGACATTCA AAAAGATTTT 3240

TCCGCGATGG GAGCACTTGC ATTGAGTGCT GATTCATCGT GTAAATTGTA TTCGGACATT 3300

TCATCAACAT CTCTCATAAT TGCAAATCTT GTCAATAAAA TGACTGGTGT CTCACAATGG 3360

AAGAATAAAC TCACTGATAC GGAAATATTC GATAGAAATG AAGAAGGAAA TGATGGTGAT 3420

AAGTTGGCAA TATGTCGAAA GTTAATGCAT TGGGGACGAC ACACAAAGAG TAATCGCGGA 3480

CAGTCATGCG CTGCACACAG TGAAATAATT CGTTTATCCC GTAAAACTTC AAATTGTGAA 3540

CTCGCGTTCT TTCACATAAA TTCAGCTATT CGAGGTGAAA AACTAGCTGC TTGGCAGAGA 3600

TTAGAAGTGG AAAGACAGCG ACTGAAACTA GTGAAAACTC AAAATTTGGA TGTGCGAATT 3660

CGTGAAATGA ATGAAGTGTT CGGATCCTTG GCTGAAGTTT TTACGACAAG TTGTCAACTG 3720

AAATCAGACT TTCAAATGGT TGATGGAATG ATTAAAGAAA AAATGATCTC CGAAGGATAT 3780

AATGAAGATA TTGCAAAGCG TGAGGAGCAC ATGAGTCGAG CCAGTATTCA ACTTGCAGAC 3840

TTTTTCCAAT CACTTCCAGA ACTTGAAAAT GTACTTGCGC CCAACCTGTT CCCGACAATT 3900

ATTTGGAGTG AACTACAACG TCGATCAGAT AGTTTATCTG CTGGATATCA TGGAATAGTT 3960

GGATCTCTCT TTCATTTGGC ATCTGAAATG TGTCCATCTC TCGCTAAAGC TCATCTCAAA 4020

ATGGCCAGAT GGGCATATGA AATCGCTAAA ATCAAGAATT TCCCTGCTGA AAATTTAAGT 4080

TTCTACAAAT TTGGAAAAGA CGAAACTGAA AACGAGGAGC TATTGAAGAG CCTGGAAGCG 4140

ACGAGTCTTG TTAATTTGGA AAAGCTTGTT CGAGCTGCAA TTTCTGATGA TTTGAGAGCA 4200

AACAACATTC TGGCACCCAA TAGTCACTTT ATGCACATTT GGAAAATGGT TCGGGATCAT 4260

CGCACGAAAT TCTTGTCAAT TGCTGTGACT TCATATTTCC AATTTATTCA GAATATGTCC 4320

GGTGATTGTG ATAATCTACC GTACTCGAAA AAAGAGGAGA CCACTTTGGC GACATTGAGA 4380

ATTCTAGAAC TTCTTGTCAA ACATGGCGAT GTTCTCATTG ATGTAATAAA TGATGGACTA 4440

AATAAGACTA ATGTACATAT TTGGAAAGAA ATTCTTCCTC AATTGTTTGC TCGCTTGTCC 4500

CATCCATCTG AACATATTCG AAAAACTCTT GTTGATCTAA TTTCAAAAAT CTGTACAGCT 4560

GCACCACATG CAGTCGTTTT TCAAGTTGTT TCTGGTGCTG CATCATCTTC TACAGACGGT 4620

GAAGAACTTG AAGAGCAGCA GAATGATGAT CGTAACCGAG TACGTGCATG CTGTGAGAAA 4680

TTGGAGACAA ATATGTCACA ATCATATCCG AATCTTGTGA AAGATGTACG GCAGTTTGTA 4740

GCAGAACTTG AACGAATTAA TCTTTTGAAT GAAGAGAAAT GGTCTGTTGT CATGGGAACA 4800

ATGGAACATG AAATGGAAAA ACGATTATCA TTGATTAGAA CTGAAAATGC GAAAACTGAA 4860

TCGGCTCTTC ATTTAACAGC TTCAGTCAAA AATGATATTA TTGTGAAAAG AACCCAATTG 4920

TTGACTAGAC AGATATTTGA TGTACTCGAT GAGCTCTACC AACAAACAGT CATTGAGCCT 4980

CCAAAGAGCA AGAATGAAGA AGAGTTTGTA ACAGCTTTTG CCGAAGTACT CACAAACGCT 5040

TTTCAAGAGT CCAGAATATC ACGTACCACT TCTCCGGAAA AGTCATGGAT TCCATTTAAA 5100

AATCTCATTG CCAATTTTGT GCATCGAAAC AGCAAAAAAG GAATGCAAAC ATTTGAAACG 5160

GAAGACATTT CTCCGTACCT CGCATCTCTT TCCAATTCGT GTGTTCCAAT GCCAGGTCAA 5220

GAATCTGTCG AGTTTGATAG AGTTGTTTCG ATATCTCGTG TTGCTCGACA AGTCACAATT 5280

CTGCCCACGA AAACTCGCCC GAAAAAGCTG GGATTTGTCG GATCTGATGG AAAACAAGTT 5340

GCATTTTTAT TCAAAGGACG CGAAGATCTT CATCTTGATG AACGAGTCAT GCAATTCCTC 5400

CGATTATGTA ATGTGATGCT TCAACCAGGA AAAGGGAAAC ATCGACAATC GGTTGCCGCG 5460

TATCAGGCAC ATCATTATGC TGTTATTCCA CTTGGACCAC GTTCTGGACT TATCAAATGG 5520

GTTGAAGGTG CTACACCAAT GTTCCACATA TATCGTAAAT GGCAGATGAA AGAGAAAGCA 5580

CTCAAACAAG CGACCAAAAA GAACGGAGAA ACAGTTCCTG AAATCGAAAG ACCCAGCAAC 5640

ATGTATCACA ATATGATTCG TCTAGCATTC GCAGATCATA AAATCGATTC CTCCATCACC 5700

TCGGATCGTT CTAAATGGCC AGCAGAAATT TTGGAAGAAG TATTTGAAAG TCTCACAGCA 5760

AAAACACCAA CAGATTTAAT CAGTCGTGAG CTTTGGATGC GTGCGAATGA TGCAACAACT 5820

TGGTGGTCGG TTACAAAACG ATATTCAAGA TCACTGGCAG TCATGAGTAT GGTTGGATCA 5880

GTTTTAGGAC TCGGTGATCG ACATTTGGAC AATTTATTGG TTGATTTGAA GTGGGGTCAT 5940

GTAGTACATA TTGACTACAA CATTTGCTTT GACAAGGGAA AGAATCTGCG TATCCCCGAA 6000

ACAGTCCCAT TCCGTTTGAC ACGTAACATG CGTCACGCTC TCGGACCATC TGAAATGTAT 6060

GGTACCTTCC GTGAATCTTG TGTTCACGTG CTCTCAACTC TTCGTTCTGG TCATCAAGTT 6120

CTTACAATGC TTCTCGATGC ATTTGTATTC GATCCGCTTG TCGATTGGAC ATCACATGAA 6180

CATACAGCAA CTTCTGGTGT CTCATTGGCA CTACAATTGG CTGTTTATGG AAGTAATTGG 6240

AAGACAAAAG CTAAAGAAAG ATTGACCGAT GCGATGGAGT TACTCAATTT GAGAATGTCT 6300

GAGGTTCAAA CCCTTTGGCT TGCAAATCGT GATGACCTTC TCCACTGGAT GAAACAAGTG 6360

ACCGAATGTC TTTTGATTGA AAATTCGATG CTTGGAGCAA ATGCCATATA TGCTCAGCAA 6420

CGTGTGAAAG CTGGAACGGA ACTTCGTGAG GCTGTGACAC GTCATCATGC ACTTGCCAAA 6480

GAGCTTCGTC CATTGATAAG AGTAATTGGA AAGGAACGAG AAGAGTTTGC AGATTATTTG 6540

AAGTTTTACA AGCAGGCATT ATTTGATCCA CTTTTGAAAG GACACTCGGC TCTCCGTAAC 6600

GAACTCGATA TTGATACATG TGTGTACAAT TTCAACATTG TCATGCAAAA TATAGATAAT 6660

GTGTTTGGAG CACTCGTCAA TCTGTCATTC ACCCCGATTG AGACTATTAC ATCCCGTACT 6720

TCACAGCAAG AATTCAAACC ACCTCCCGGA CTTGAAAATG TATGGGTTGT GAAACAAGAT 6780

CAACAGGAGA ATTCTCAAGC GCGTGAAGTT GTCCGACGTG TTGAACGGCG TCTCAACGGA 6840

TGGCTCGATG GATCGGCAGG ACCAGATAGG AAATTGTCTC CTCGCGAAGA GGCCGACATC 6900

CTAATCGCTG AAGCTACATC CACACCAAAT TTATCTCAAA TGTACGAAGG ATGGACTGCT 6960

TGGGTCTGA 6969

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i +++ +v+il++k++pkkl + Gsdgk+ ++L+kg+eDl+ derv+q+++l+N +L+

Q: 1751  ISRVARQVTILPTKTRPKKLGFVGSDGKQVAFLFKGREDLHLDERVMQFLRLCNVMLQPG  1810

         678899***************************************************986

S: 61    ketsrr...kLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyry  117

         k  +r+   + ++ +y+V+pl++rsgli+wve++++++++++k++ k+++l +   +++

Q: 1811  KGKHRQsvaAYQAHHYAVIPLGPRSGLIKWVEGATPMFHIYRKWQMKEKALKQ-ATKKNG  1869

         6555541117899*******************************877777664.222222

S: 118   kdlstvqar.........kpklkhlkls..................levfkevlenlv..  148

         +  +++ +                                       e+++ev e l+

Q: 1870  ETVPEIERPsnmyhnmirL--------AfadhkidssitsdrskwpAEILEEVFESLTak  1921

         2222222221122233332........033444444666677999966666666655555

S: 149   .pkdllkklllekfpspeewfelrkaytrslAvislvgyiLgLgdrhlenllidqetgev  207

          p dl+ ++l+    +++ w++++k y rslAv+s+vg +LgLgdrhl+nll+d + g+v

Q: 1922  tPTDLISRELWMRANDATTWWSVTKRYSRSLAVMSMVGSVLGLGDRHLDNLLVDLKWGHV  1981

         5***********************************************************

S: 208   vhidfgvafekaktqlkvpekvPFRLTrnivnalgvtgveGvfrasceavlrvlreskek  267

         vhid++++f+k+k  l++pe+vPFRLTrn+  alg+  + G fr sc++vl  lr+ ++

Q: 1982  VHIDYNICFDKGKN-LRIPETVPFRLTRNMRHALGPSEMYGTFRESCVHVLSTLRSGHQV  2040

         **************.*********************************************

S: 268   lltiLevflydplvdwkkkkktsk  291

         l+ +L++f+ dplvdw+  ++++

Q: 2041  LTMLLDAFVFDPLVDWTS-HEHTA  2063

         *****************7.33333

Domain Sequence
(FASTA)

ISRVARQVTI LPTKTRPKKL GFVGSDGKQV AFLFKGREDL HLDERVMQFL RLCNVMLQPG 60

KGKHRQSVAA YQAHHYAVIP LGPRSGLIKW VEGATPMFHI YRKWQMKEKA LKQATKKNGE 120

TVPEIERPSN MYHNMIRLAF ADHKIDSSIT SDRSKWPAEI LEEVFESLTA KTPTDLISRE 180

LWMRANDATT WWSVTKRYSR SLAVMSMVGS VLGLGDRHLD NLLVDLKWGH VVHIDYNICF 240

DKGKNLRIPE TVPFRLTRNM RHALGPSEMY GTFRESCVHV LSTLRSGHQV LTMLLDAFVF 300

DPLVDWTSHE HTA 313

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Manganese; Metal-binding; Nonsense-mediated mRNA decay; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0016303	; F:1-phosphatidylinositol-3-kinase activity
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0040035	; P:hermaphrodite genitalia development
GO:0030539	; P:male genitalia development
GO:0000184	; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

KEGG

cel:CELE_C48B6.6

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR014009	; PIK_FAT.

Pfam

PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; FALSE_NEG.
PS00915	; PI3_4_KINASE_1; FALSE_NEG.
PS00916	; PI3_4_KINASE_2; FALSE_NEG.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013